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C1KZ32

- THIM_LISMC

UniProt

C1KZ32 - THIM_LISMC

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate; via amide nitrogenUniRule annotation
Binding sitei118 – 1181ATPUniRule annotation
Binding sitei164 – 1641ATPUniRule annotation
Binding sitei191 – 1911Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMON568819:GJF9-487-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:Lm4b_00335
OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
Taxonomic identifieri568819 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002203: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Hydroxyethylthiazole kinasePRO_0000383883Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi634178.Lm4b_00335.

Structurei

3D structure databases

ProteinModelPortaliC1KZ32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

C1KZ32-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFDFMTLEKV WEKGPLVHNI TNIVVANDSA NGLLAIGASP IMASAKEEMD
60 70 80 90 100
ELAKMADVLV INIGTLDGEL VTAMKIAGRA ANVAGTPVVL DPVGVGATSY
110 120 130 140 150
RRKVVQELLA EIQFTAIRGN AGELAAIAGE AWEAKGVDAG VGSADVLSIA
160 170 180 190 200
EKVANEWSTV VIISGEVDVI SDGTRFAKVA NGSALLPRIT GSGCLLSAVC
210 220 230 240 250
GSFMAVQDDA FRASVEACAS YAVASEYAEI ELERKLPGSF RPQFLDALAS
260
WSVEKTRAKA KIQESGEHK
Length:269
Mass (Da):28,199
Last modified:May 26, 2009 - v1
Checksum:iAE077027D291A385
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS04102.1.
RefSeqiYP_002757050.1. NC_012488.1.

Genome annotation databases

EnsemblBacteriaiCAS04102; CAS04102; Lm4b_00335.
GeneIDi7703729.
KEGGilmc:Lm4b_00335.
PATRICi20303774. VBILisMon88360_0323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS04102.1 .
RefSeqi YP_002757050.1. NC_012488.1.

3D structure databases

ProteinModelPortali C1KZ32.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 634178.Lm4b_00335.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAS04102 ; CAS04102 ; Lm4b_00335 .
GeneIDi 7703729.
KEGGi lmc:Lm4b_00335.
PATRICi 20303774. VBILisMon88360_0323.

Phylogenomic databases

HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci LMON568819:GJF9-487-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP80459.

Entry informationi

Entry nameiTHIM_LISMC
AccessioniPrimary (citable) accession number: C1KZ32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3