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C1KYN8 (NAMA_LISMC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADPH dehydrogenase
EC=1.6.99.1
Alternative name(s):
Xenobiotic reductase
Gene names
Name:namA
Ordered Locus Names:Lm4b_02440
OrganismListeria monocytogenes serotype 4b (strain Clip81459) [Complete proteome] [HAMAP]
Taxonomic identifier568819 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of the double bond of an array of alpha, beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity. HAMAP MF_01614

Catalytic activity

NADPH + acceptor = NADP+ + reduced acceptor. HAMAP MF_01614

Cofactor

FMN By similarity. HAMAP MF_01614

Subunit structure

Homotetramer By similarity. HAMAP MF_01614

Sequence similarities

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338NADPH dehydrogenase HAMAP MF_01614
PRO_1000215712

Regions

Nucleotide binding22 – 265FMN By similarity

Sites

Binding site271Substrate By similarity
Binding site1631Substrate By similarity
Binding site1661Substrate By similarity
Binding site2141FMN By similarity
Binding site3071FMN By similarity

Sequences

Sequence LengthMass (Da)Tools
C1KYN8 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: FEBCAE68FEB2D5A0

FASTA33837,049
        10         20         30         40         50         60 
MSKLFSEYKL KDVTLKNRIV MSPMCMYSVE NKDGIATDFH FAHYVSRAAG GTGLVILEAT 

        70         80         90        100        110        120 
AVQEVGRISE FDLGLWNDEQ VPALKKLVDG LHYHGAKAGI QLAHAGRKAV LPGEIVAPSA 

       130        140        150        160        170        180 
IAFDEKSDKP VELTKEAIKE VVADFKRAAY RAKEAGFDVI EIHAAHGYLI HQFLSPITNR 

       190        200        210        220        230        240 
REDNYGGPAG NRYKILSDII KAVKEVWDGP IIVRVSATDY AHGGLQLEDH IPFAKWMKAD 

       250        260        270        280        290        300 
GVELIDVSTG GLVNVAPPVF PGYQVPFADE IRRGAGIATG ALGLITRGEQ AEEILCNERA 

       310        320        330 
DLIIVGRELL RNPYFAKDAA KQLGETIEGP KQYSRAWK

« Hide

References

[1]"Complete genome sequence of Listeria monocytogenes serotype 4b strain Clip81459."
Rusniok C.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Clip81459.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM242711 Genomic DNA. Translation: CAS06195.1.
RefSeqYP_002759126.1. NC_012488.1.

3D structure databases

ProteinModelPortalC1KYN8.
SMRC1KYN8. Positions 3-337.
ModBaseSearch...

Protein-protein interaction databases

STRINGC1KYN8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7704100.
GenomeReviewsGene locus Lm4b_02440 in contig FM242711_GR.
KEGGlmc:Lm4b_02440.
PATRIC20308187. VBILisMon88360_2465.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAWVEDGWN.
ProtClustDBPRK13523.

Family and domain databases

HAMAPMF_01614. NamA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00540.
PfamPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAMA_LISMC
AccessionPrimary (citable) accession number: C1KYN8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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