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C1KXF7 (C1KXF7_LISMC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:Lm4b_02229
OrganismListeria monocytogenes serotype 4b (strain Clip81459) [Complete proteome] [HAMAP]
Taxonomic identifier568819 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region238 – 2425ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2371 By similarity HAMAP MF_01815
Active site2671 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
C1KXF7 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: E87AE337231DE3DD

FASTA31233,971
        10         20         30         40         50         60 
MNAGILGVGK YVPEKIVTNF DLEKIMDTSD EWIRTRTGIE ERRIARDDEY THDLAYEAAK 

        70         80         90        100        110        120 
VAIKNAGLTP DDIDLFIVAT VTQEATFPSV ANIIQDRLGA KNAAGMDVEA ACAGFTFGVV 

       130        140        150        160        170        180 
TAAQFIKTGA YKNIVVVGAD KLSKITNWDD RTTAVLFGDG AGAVVMGPVS DDHGLLSFDL 

       190        200        210        220        230        240 
GSDGSGGKYL NLDENKKIYM NGREVFRFAV RQMGEASLRV LERAGLEKED LDLLIPHQAN 

       250        260        270        280        290        300 
IRIMEASRER LNLPEEKLMK TVHKYGNTSS SSIALALVDA VEEGRIKDND NVLLVGFGGG 

       310 
LTWGALIIRW GK

« Hide

References

[1]"Complete genome sequence of Listeria monocytogenes serotype 4b strain Clip81459."
Rusniok C.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM242711 Genomic DNA. Translation: CAS05986.1.
RefSeqYP_002758917.1. NC_012488.1.

3D structure databases

ProteinModelPortalC1KXF7.
SMRC1KXF7. Positions 1-311.
ModBaseSearch...

Protein-protein interaction databases

STRINGC1KXF7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7702854.
GenomeReviewsGene locus Lm4b_02229 in contig FM242711_GR.
KEGGlmc:Lm4b_02229.
PATRIC20307707. VBILisMon88360_2246.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAKEIGAIN.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC1KXF7_LISMC
AccessionPrimary (citable) accession number: C1KXF7
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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