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C1KX43

- ASSY_LISMC

UniProt

C1KX43 - ASSY_LISMC

Protein

Argininosuccinate synthase

Gene

argG

Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861CitrullineUniRule annotation
    Binding sitei116 – 1161ATP; via amide nitrogenUniRule annotation
    Binding sitei118 – 1181AspartateUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei122 – 1221CitrullineUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei126 – 1261CitrullineUniRule annotation
    Binding sitei174 – 1741CitrullineUniRule annotation
    Binding sitei183 – 1831CitrullineUniRule annotation
    Binding sitei259 – 2591CitrullineUniRule annotation
    Binding sitei271 – 2711CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 179ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLMON568819:GJF9-3118-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Lm4b_02111
    OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
    Taxonomic identifieri568819 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000002203: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Argininosuccinate synthasePRO_1000201685Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi634178.Lm4b_02111.

    Structurei

    3D structure databases

    ProteinModelPortaliC1KX43.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1KX43-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKEKIVLAY SGGLDTSVAI QWLVESGYEV IACCLDVGEG KNLDFIKEKA    50
    ITVGASESYT IDAKEEFAED FALIALQAHA YYEGKYPLIS ALSRPLIAKK 100
    LVEVARQEGA SAIAHGCTGK GNDQVRFEVA IHALAPDLKV VSPVRDWKWS 150
    REEEINYAKE HNIPVPIDLD NPFSIDQNLW GRSNECGVLE NPWTTPPEAA 200
    YDLTVSLEDA PDTPDIVEIT FDAGIPISLN GENMSLANLI LTLNEIAGKH 250
    GVGRIDHIEN RLVGIKSREV YECPAAVTLI TAHKELEDLT FVREVAHFKP 300
    IIEQKISETI YNGLWFSPLT EALVAFLKST QKFVNGTIRV KLFKGHAIVE 350
    GRKSPNSLYD ENLATYTSSD TFDQDAAVGF IKLWGLPTKV SAEVNSKVTI 400
    TTEV 404
    Length:404
    Mass (Da):44,478
    Last modified:May 26, 2009 - v1
    Checksum:iD3A516157056D70F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM242711 Genomic DNA. Translation: CAS05871.1.
    RefSeqiYP_002758803.1. NC_012488.1.

    Genome annotation databases

    EnsemblBacteriaiCAS05871; CAS05871; Lm4b_02111.
    GeneIDi7703150.
    KEGGilmc:Lm4b_02111.
    PATRICi20307461. VBILisMon88360_2128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM242711 Genomic DNA. Translation: CAS05871.1 .
    RefSeqi YP_002758803.1. NC_012488.1.

    3D structure databases

    ProteinModelPortali C1KX43.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 634178.Lm4b_02111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAS05871 ; CAS05871 ; Lm4b_02111 .
    GeneIDi 7703150.
    KEGGi lmc:Lm4b_02111.
    PATRICi 20307461. VBILisMon88360_2128.

    Phylogenomic databases

    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci LMON568819:GJF9-3118-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIP80459.

    Entry informationi

    Entry nameiASSY_LISMC
    AccessioniPrimary (citable) accession number: C1KX43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3