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C1KWW2

- DAPF_LISMC

UniProt

C1KWW2 - DAPF_LISMC

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Protein
Diaminopimelate epimerase
Gene
dapF, Lm4b_02030
Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Substrate By similarity
Binding sitei53 – 531Substrate By similarity
Binding sitei73 – 731Substrate By similarity
Active sitei82 – 821Proton donor/acceptor By similarity
Binding sitei170 – 1701Substrate By similarity
Sitei172 – 1721Important for catalytic activity By similarity
Binding sitei206 – 2061Substrate By similarity
Sitei224 – 2241Important for catalytic activity By similarity
Active sitei233 – 2331Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciLMON568819:GJF9-2999-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:Lm4b_02030
OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
Taxonomic identifieri568819 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002203: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Diaminopimelate epimeraseUniRule annotation
PRO_1000204063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi82 ↔ 233UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi634178.Lm4b_02030.

Structurei

3D structure databases

ProteinModelPortaliC1KWW2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 843Substrate binding By similarity
Regioni224 – 2252Substrate binding By similarity
Regioni234 – 2352Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000220466.
KOiK01778.
OMAiKDITVMV.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1KWW2-1 [UniParc]FASTAAdd to Basket

« Hide

METIHFTKVH GSQNDFFLVD EEENHITEWS DEKRANFAIK LCDRKHSLGG    50
ADGILYVTKS SEVGPIGQMR VVNSDGSIAS MCGNGLRTVA RYLLEKHALT 100
DAKVETMKAI LDVKKATSLG FDIPTYQVEI SPVKFAAETL PMHVGVEKLF 150
NQVIPELDAE LAFSAVSVPN PHLITFVDQA VLDSNKQEKL ASYLNSENPY 200
FPDGVNVSFV KRLSDDAIYV RTFERGVGFT NACGTAMSAC SLIKKMLDND 250
ILETPLNVYN DGGRVQVTAK KDAAGEISLQ LIGNATFVSK GSVRYENDVV 300
TELTNEATDE QGQYQALVKE VKEFLKTTE 329
Length:329
Mass (Da):36,227
Last modified:May 26, 2009 - v1
Checksum:i5209E21E5F43C0A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM242711 Genomic DNA. Translation: CAS05788.1.
RefSeqiYP_002758722.1. NC_012488.1.

Genome annotation databases

EnsemblBacteriaiCAS05788; CAS05788; Lm4b_02030.
GeneIDi7703974.
KEGGilmc:Lm4b_02030.
PATRICi20307297. VBILisMon88360_2047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM242711 Genomic DNA. Translation: CAS05788.1 .
RefSeqi YP_002758722.1. NC_012488.1.

3D structure databases

ProteinModelPortali C1KWW2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 634178.Lm4b_02030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAS05788 ; CAS05788 ; Lm4b_02030 .
GeneIDi 7703974.
KEGGi lmc:Lm4b_02030.
PATRICi 20307297. VBILisMon88360_2047.

Phylogenomic databases

HOGENOMi HOG000220466.
KOi K01778.
OMAi KDITVMV.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci LMON568819:GJF9-2999-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP80459.

Entry informationi

Entry nameiDAPF_LISMC
AccessioniPrimary (citable) accession number: C1KWW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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