C1KWM7 (AROB_LISMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate synthase
EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Lm4b_01944

Organism

Listeria monocytogenes serotype 4b (strain Clip81459) [Complete proteome] [HAMAP]

Taxonomic identifier

568819 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000202914

Sequences

	Sequence		Length	Mass (Da)
	C1KWM7 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 83D2C2B014547BBA	FASTA	365	41,199
	10 20 30 40 50 60 MPEITVRAKS KTYPVYINEF ALEDVREKWT ESLAKFSHVF VLTDEHVAEL HKAKLDAVLA 70 80 90 100 110 120 DLPVVTYYVA PNGEEAKTFR VYEDVMTKLI ETGLDRKAVL IAFGGGVIGD LGGFVAATYM 130 140 150 160 170 180 RGIPFYQVPT TVLAHDSAVG GKVAINHPLG KNMIGNFYQP EAVIYDTQFF ATLPEREMRS 190 200 210 220 230 240 GFAEMIKHAL ISDQTLLRAL MDTFTEPKDF YTKDLTPFLQ RGIEIKANIV AQDETEQGVR 250 260 270 280 290 300 AYLNFGHTFG HALEAYGNFG KWLHGEAITY GMIYALTMSE TIYGLDFDLA EFKTWLKQLG 310 320 330 340 350 360 YDTTFDATVP FNKILENMRH DKKTTFNEIS MVLLEEIGKP VIFKAEDDLI FETYKRVMRN GGNGI

References

[1]	"Complete genome sequence of Listeria monocytogenes serotype 4b strain Clip81459." Rusniok C. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Clip81459.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM242711 Genomic DNA. Translation: CAS05702.1.
RefSeq	YP_002758638.1. NC_012488.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C1KWM7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7703029.
GenomeReviews	Gene locus Lm4b_01944 in contig FM242711_GR.
KEGG	lmc:Lm4b_01944.
PATRIC	20307119. VBILisMon88360_1958.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	AYLNFGH.
ProtClustDB	PRK00002.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016037. DHQ_synth_AroB. [Graphical view]
KO	K01735.
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. AroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_LISMC

Accession

Primary (citable) accession number: C1KWM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program