Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C1KWH6

- FTHS_LISMC

UniProt

C1KWH6 - FTHS_LISMC

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 768ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Lm4b_01893
    OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
    Taxonomic identifieri568819 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000002203: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Formate--tetrahydrofolate ligasePRO_1000215438Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi634178.Lm4b_01893.

    Structurei

    3D structure databases

    ProteinModelPortaliC1KWH6.
    SMRiC1KWH6. Positions 8-558.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1KWH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNKVKSDIE IASKAEILPV TTIAEHLGLD ADALELYGKY KAKLSYDTIH    50
    SLKDKEPGKL VLVTAINPTP AGEGKSTVTV GLGDALSKKD KKTVIALREP 100
    SLGPTMGIKG GATGGGYAQV IPMEDINLHF TGDFHAITAA NNALSAFIDN 150
    HMQQGNDLDI DGRRIVWKRV VDLNDRALRK VVVGLGGPIQ GVPREDGFDI 200
    TVASEIMAII CLASDLKDLK KRLSEIVIGY NYKKEPITVG EMGYEGALTL 250
    LLKDALKPNL VQTLEHTPAI VHGGPFANIA HGCNSVSATS TALRLGEYVV 300
    TEAGFGADLG AEKFLDIKVP ALGKAPDCVV IVATIRALKM HGGALKTELS 350
    EENVDALAKG FTNLQKHTES IQTFGIPYVV AINKFITDSD AEVAKLEALC 400
    EEHGIPFSLT EVWEKGGDGG LELADKVIAA VESGEADYKR IYDDAWSIEE 450
    KLEAIVTKVY GGIGVELSSK AQKQIVEFKK YGWDRYPICM AKTQYSLSDD 500
    PTLLGRPTDF VIHIREFIPK LGAGFVVALT GDVMTMPGLP KKPAALNMDV 550
    DENGNAQGLF 560
    Length:560
    Mass (Da):60,126
    Last modified:May 26, 2009 - v1
    Checksum:iB0D92B76E1DF66BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM242711 Genomic DNA. Translation: CAS05651.1.
    RefSeqiYP_002758587.1. NC_012488.1.

    Genome annotation databases

    EnsemblBacteriaiCAS05651; CAS05651; Lm4b_01893.
    GeneIDi7702994.
    KEGGilmc:Lm4b_01893.
    PATRICi20307017. VBILisMon88360_1907.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM242711 Genomic DNA. Translation: CAS05651.1 .
    RefSeqi YP_002758587.1. NC_012488.1.

    3D structure databases

    ProteinModelPortali C1KWH6.
    SMRi C1KWH6. Positions 8-558.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 634178.Lm4b_01893.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAS05651 ; CAS05651 ; Lm4b_01893 .
    GeneIDi 7702994.
    KEGGi lmc:Lm4b_01893.
    PATRICi 20307017. VBILisMon88360_1907.

    Phylogenomic databases

    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIP80459.

    Entry informationi

    Entry nameiFTHS_LISMC
    AccessioniPrimary (citable) accession number: C1KWH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3