C1KWH6 (FTHS_LISMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	Lm4b_01893

Organism

Listeria monocytogenes serotype 4b (strain Clip81459) [Complete proteome] [HAMAP]

Taxonomic identifier

568819 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_1000215438
Regions
	Nucleotide binding	69 – 76	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1KWH6 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: B0D92B76E1DF66BC	FASTA	560	60,126
	10 20 30 40 50 60 MSNKVKSDIE IASKAEILPV TTIAEHLGLD ADALELYGKY KAKLSYDTIH SLKDKEPGKL 70 80 90 100 110 120 VLVTAINPTP AGEGKSTVTV GLGDALSKKD KKTVIALREP SLGPTMGIKG GATGGGYAQV 130 140 150 160 170 180 IPMEDINLHF TGDFHAITAA NNALSAFIDN HMQQGNDLDI DGRRIVWKRV VDLNDRALRK 190 200 210 220 230 240 VVVGLGGPIQ GVPREDGFDI TVASEIMAII CLASDLKDLK KRLSEIVIGY NYKKEPITVG 250 260 270 280 290 300 EMGYEGALTL LLKDALKPNL VQTLEHTPAI VHGGPFANIA HGCNSVSATS TALRLGEYVV 310 320 330 340 350 360 TEAGFGADLG AEKFLDIKVP ALGKAPDCVV IVATIRALKM HGGALKTELS EENVDALAKG 370 380 390 400 410 420 FTNLQKHTES IQTFGIPYVV AINKFITDSD AEVAKLEALC EEHGIPFSLT EVWEKGGDGG 430 440 450 460 470 480 LELADKVIAA VESGEADYKR IYDDAWSIEE KLEAIVTKVY GGIGVELSSK AQKQIVEFKK 490 500 510 520 530 540 YGWDRYPICM AKTQYSLSDD PTLLGRPTDF VIHIREFIPK LGAGFVVALT GDVMTMPGLP 550 560 KKPAALNMDV DENGNAQGLF

References

[1]	"Complete genome sequence of Listeria monocytogenes serotype 4b strain Clip81459." Rusniok C. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Clip81459.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM242711 Genomic DNA. Translation: CAS05651.1.
RefSeq	YP_002758587.1. NC_012488.1.
3D structure databases
ProteinModelPortal	C1KWH6.
SMR	C1KWH6. Positions 8-558.
ModBase	Search...
Protein-protein interaction databases
STRING	C1KWH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7702994.
GenomeReviews	Gene locus Lm4b_01893 in contig FM242711_GR.
KEGG	lmc:Lm4b_01893.
PATRIC	20307017. VBILisMon88360_1907.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EIMAVLC.
ProtClustDB	PRK13505.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_LISMC

Accession

Primary (citable) accession number: C1KWH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program