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C1KWH6

- FTHS_LISMC

UniProt

C1KWH6 - FTHS_LISMC

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Lm4b_01893
Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Lm4b_01893
OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
Taxonomic identifieri568819 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002203: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000215438Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi634178.Lm4b_01893.

Structurei

3D structure databases

ProteinModelPortaliC1KWH6.
SMRiC1KWH6. Positions 8-558.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1KWH6-1 [UniParc]FASTAAdd to Basket

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MSNKVKSDIE IASKAEILPV TTIAEHLGLD ADALELYGKY KAKLSYDTIH    50
SLKDKEPGKL VLVTAINPTP AGEGKSTVTV GLGDALSKKD KKTVIALREP 100
SLGPTMGIKG GATGGGYAQV IPMEDINLHF TGDFHAITAA NNALSAFIDN 150
HMQQGNDLDI DGRRIVWKRV VDLNDRALRK VVVGLGGPIQ GVPREDGFDI 200
TVASEIMAII CLASDLKDLK KRLSEIVIGY NYKKEPITVG EMGYEGALTL 250
LLKDALKPNL VQTLEHTPAI VHGGPFANIA HGCNSVSATS TALRLGEYVV 300
TEAGFGADLG AEKFLDIKVP ALGKAPDCVV IVATIRALKM HGGALKTELS 350
EENVDALAKG FTNLQKHTES IQTFGIPYVV AINKFITDSD AEVAKLEALC 400
EEHGIPFSLT EVWEKGGDGG LELADKVIAA VESGEADYKR IYDDAWSIEE 450
KLEAIVTKVY GGIGVELSSK AQKQIVEFKK YGWDRYPICM AKTQYSLSDD 500
PTLLGRPTDF VIHIREFIPK LGAGFVVALT GDVMTMPGLP KKPAALNMDV 550
DENGNAQGLF 560
Length:560
Mass (Da):60,126
Last modified:May 26, 2009 - v1
Checksum:iB0D92B76E1DF66BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM242711 Genomic DNA. Translation: CAS05651.1.
RefSeqiYP_002758587.1. NC_012488.1.

Genome annotation databases

EnsemblBacteriaiCAS05651; CAS05651; Lm4b_01893.
GeneIDi7702994.
KEGGilmc:Lm4b_01893.
PATRICi20307017. VBILisMon88360_1907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM242711 Genomic DNA. Translation: CAS05651.1 .
RefSeqi YP_002758587.1. NC_012488.1.

3D structure databases

ProteinModelPortali C1KWH6.
SMRi C1KWH6. Positions 8-558.
ModBasei Search...

Protein-protein interaction databases

STRINGi 634178.Lm4b_01893.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAS05651 ; CAS05651 ; Lm4b_01893 .
GeneIDi 7702994.
KEGGi lmc:Lm4b_01893.
PATRICi 20307017. VBILisMon88360_1907.

Phylogenomic databases

HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP80459.

Entry informationi

Entry nameiFTHS_LISMC
AccessioniPrimary (citable) accession number: C1KWH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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