C1KWD7 (PYRB_LISMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Lm4b_01854

Organism

Listeria monocytogenes serotype 4b (strain Clip81459) [Complete proteome] [HAMAP]

Taxonomic identifier

568819 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000201595

Sequences

	Sequence		Length	Mass (Da)
	C1KWD7 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 9873FA6E02168957	FASTA	303	34,183
	10 20 30 40 50 60 MKNLLSMEAL TVHEIEHLLE QAAQFKRGKK ATFNEQTFAV NMFFEPSTRT HTSFEVAEKK 70 80 90 100 110 120 LGVEVVSFDA ASSSMTKGET LYDTLLTMQA VGVNVAVIRH SEENYYAGLE KLDIAIVNGG 130 140 150 160 170 180 DGCGEHPSQS LLDLFTIKEQ FGTFQGLKVA IAGDIRHSRV ANSNMKVLKR LGAELFFSGP 190 200 210 220 230 240 REWFDESYLA YGTYLSVDEI VEKVDVLMLL RVQHERHSGT DEFTKESYHE KFGLTENRAK 250 260 270 280 290 300 QLKEDAIIMH PSPVNRDVEI ADSLVESEKS RIVTQMTNGV FIRMAILEAI LKEQEMRAKL CTY

References

[1]	"Complete genome sequence of Listeria monocytogenes serotype 4b strain Clip81459." Rusniok C. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Clip81459.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM242711 Genomic DNA. Translation: CAS05612.1.
RefSeq	YP_002758548.1. NC_012488.1.
3D structure databases
ProteinModelPortal	C1KWD7.
ModBase	Search...
Protein-protein interaction databases
STRING	C1KWD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7702571.
GenomeReviews	Gene locus Lm4b_01854 in contig FM242711_GR.
KEGG	lmc:Lm4b_01854.
PATRIC	20306939. VBILisMon88360_1868.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VGIPIIN.
ProtClustDB	PRK00856.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_LISMC

Accession

Primary (citable) accession number: C1KWD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program