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C1KWD1

- PYRF_LISMC

UniProt

C1KWD1 - PYRF_LISMC

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, Lm4b_01848
Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Substrate By similarity
Binding sitei31 – 311Substrate By similarity
Active sitei60 – 601Proton donor By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei182 – 1821Substrate By similarity
Binding sitei191 – 1911Substrate By similarity
Binding sitei211 – 2111Substrate; via amide nitrogen By similarity
Binding sitei212 – 2121Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciLMON568819:GJF9-2748-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:Lm4b_01848
OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
Taxonomic identifieri568819 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002203: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_1000213822Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi634178.Lm4b_01848.

Structurei

3D structure databases

ProteinModelPortaliC1KWD1.
SMRiC1KWD1. Positions 5-232.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 6710Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000226071.
KOiK01591.
OMAiRPITQSA.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1KWD1-1 [UniParc]FASTAAdd to Basket

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MNKPIIALDF QTYEEVETFL AKFSGETLSV KVGMELFYSN GPIIVEKIKQ    50
QHHEIFLDLK LHDIPNTVKS AMIGLAKLGV DMVNVHAAGG KKMMEAAREG 100
LEIGSSSGKR PKIIAVTQLT STSETDMQTE QLIKTSLLES VMHYSNLSKQ 150
AGLDGVVCSA LEAEDIKQQN GADFLRVTPG IRLASDAADD QIRVVTPEKA 200
RLIGSSNIVV GRSITRANDP VEAYNQVLKE WNA 233
Length:233
Mass (Da):25,455
Last modified:May 26, 2009 - v1
Checksum:i759543ED58F4795E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM242711 Genomic DNA. Translation: CAS05606.1.
RefSeqiYP_002758542.1. NC_012488.1.

Genome annotation databases

EnsemblBacteriaiCAS05606; CAS05606; Lm4b_01848.
GeneIDi7702636.
KEGGilmc:Lm4b_01848.
PATRICi20306927. VBILisMon88360_1862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM242711 Genomic DNA. Translation: CAS05606.1 .
RefSeqi YP_002758542.1. NC_012488.1.

3D structure databases

ProteinModelPortali C1KWD1.
SMRi C1KWD1. Positions 5-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 634178.Lm4b_01848.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAS05606 ; CAS05606 ; Lm4b_01848 .
GeneIDi 7702636.
KEGGi lmc:Lm4b_01848.
PATRICi 20306927. VBILisMon88360_1862.

Phylogenomic databases

HOGENOMi HOG000226071.
KOi K01591.
OMAi RPITQSA.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci LMON568819:GJF9-2748-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP80459.

Entry informationi

Entry nameiPYRF_LISMC
AccessioniPrimary (citable) accession number: C1KWD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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