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C1KWD0 (C1KWD0_LISMC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208 EMBL CAS05605.1
Ordered Locus Names:Lm4b_01847
OrganismListeria monocytogenes serotype 4b (strain Clip81459) [Complete proteome] [HAMAP]
Taxonomic identifier568819 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region122 – 13095-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1261Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
C1KWD0 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: FD8607975F60EADA

FASTA20922,806
        10         20         30         40         50         60 
MSIEKQVAEQ LLEIKAVFLK PNEPFTWASG IKSPIYCDNR LTLGFPKVRQ FIAKSLAEKI 

        70         80         90        100        110        120 
KQTFGEVDVV AGTATAGIPH AAWVSDLLDL PMVYVRSKAK EHGKGNQIEG PISKGQKVVV 

       130        140        150        160        170        180 
IEDLISTGGS SLKAVEALEE AGAEVVGIAA IFTYGLAKGK QLLEESGTKL VTLTNYDELI 

       190        200 
EVALNENYVT GEDMETLKEW KKNPENWGK

« Hide

References

[1]"Complete genome sequence of Listeria monocytogenes serotype 4b strain Clip81459."
Rusniok C.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM242711 Genomic DNA. Translation: CAS05605.1.
RefSeqYP_002758541.1. NC_012488.1.

3D structure databases

ProteinModelPortalC1KWD0.
SMRC1KWD0. Positions 1-208.
ModBaseSearch...

Protein-protein interaction databases

STRINGC1KWD0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7702635.
GenomeReviewsGene locus Lm4b_01847 in contig FM242711_GR.
KEGGlmc:Lm4b_01847.
PATRIC20306925. VBILisMon88360_1861.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMALPMTYVR.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC1KWD0_LISMC
AccessionPrimary (citable) accession number: C1KWD0
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info