C1KW71 (PUR7_LISMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	Lm4b_01786

Organism

Listeria monocytogenes serotype 4b (strain CLIP80459) [Complete proteome] [HAMAP]

Taxonomic identifier

568819 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria monocytogenes

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP-Rule MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP-Rule MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP-Rule MF_00137		PRO_1000203233

Sequences

	Sequence		Length	Mass (Da)
	C1KW71 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 2E08D1E7B247C2E8	FASTA	237	26,795
	10 20 30 40 50 60 MTNELVYEGK AKRLFKTEEA GVLRVAYKDD ATALNGVRKE SFAGKGELNN QITSLIFSHL 70 80 90 100 110 120 AGAGIESHFI RAISETEQLV KEVSIIPLEV VVRNVMAGSL AKRLGKEEGE LIPNAIVEFY 130 140 150 160 170 180 YKDDALDDPF INDDHVLYLE LATTSEMDII RQAARSINKV LQELFNQMNI TLIDFKLEFG 190 200 210 220 230 RDATGNILLA DEISPDTCRL WDKETNQKLD KDVFRRNIGN LTDVYTEVLN RLKQVQN

References

[1]

"Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes." Hain T., Ghai R., Billion A., Kuenne C.T., Steinweg C., Izar B., Mohamed W., Mraheil M., Domann E., Schaffrath S., Karst U., Goesmann A., Oehm S., Puhler A., Merkl R., Vorwerk S., Glaser P., Garrido P. , Rusniok C., Buchrieser C., Goebel W., Chakraborty T. BMC Genomics 13:144-144(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIP80459.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM242711 Genomic DNA. Translation: CAS05546.1.
RefSeq	YP_002758482.1. NC_012488.1.
3D structure databases
ProteinModelPortal	C1KW71.
SMR	C1KW71. Positions 4-232.
ModBase	Search...
Protein-protein interaction databases
STRING	634178.Lm4b_01786.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAS05546; CAS05546; Lm4b_01786.
GeneID	7701711.
KEGG	lmc:Lm4b_01786.
PATRIC	20306799. VBILisMon88360_1801.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000082629.
KO	K01923.
OMA	VQYFKDD.
ProtClustDB	PRK09362.
Enzyme and pathway databases
BioCyc	LMON568819:GJF9-2660-MONOMER.
UniPathway	UPA00074; UER00131.
Family and domain databases
Gene3D	3.30.470.20. 1 hit.
HAMAP	MF_00137. SAICAR_synth.
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
PANTHER	PTHR11609. PTHR11609. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. purC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_LISMC

Accession

Primary (citable) accession number: C1KW71

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program