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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Lm4b_01781
OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
Taxonomic identifieri568819 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002128271 – 349Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST349

Proteomic databases

PRIDEiC1KW66

Structurei

3D structure databases

ProteinModelPortaliC1KW66
SMRiC1KW66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229091
KOiK01933
OMAiNHCVNDI

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.10, 1 hit
3.90.650.10, 1 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

C1KW66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENAYSKAG VDVEAGYQVV ERIKKHVART ERLGAMGALG SFGGMFDLSS
60 70 80 90 100
LHLKEPVLVS GTDGVGTKLL LAIEADKHDT IGIDCVAMCV NDILAQGAEP
110 120 130 140 150
LFFLDYIATG KTDPVKMEQI VKGVADGCEQ AGAALIGGET AEMPDMYGAE
160 170 180 190 200
DYDLAGFTVG AVEKQKLITE GAVKEGDTLI GIPSSGIHSN GYSLVRKIFF
210 220 230 240 250
KDNELTLDAE ISELDVPLVE ELLKPTRIYV KPVLEVLKEV DVHGITHVTG
260 270 280 290 300
GGFVENLPRM LTNDLAVKVE LGSWPVLPIF DVMKKYGQLS ELEMYEIFNM
310 320 330 340
GIGMVLAVAK ADVERTLEVL VQNGEAAYVI GEVTTRENDA VIFTGGTKG
Length:349
Mass (Da):37,415
Last modified:May 26, 2009 - v1
Checksum:iFBEC8E0A8FC18B16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA Translation: CAS05541.1
RefSeqiWP_003726210.1, NC_012488.1

Genome annotation databases

EnsemblBacteriaiCAS05541; CAS05541; Lm4b_01781
KEGGilmc:Lm4b_01781

Similar proteinsi

Entry informationi

Entry nameiPUR5_LISMC
AccessioniPrimary (citable) accession number: C1KW66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health