Skip Header

Contribute Send feedback
Read comments (?) or add your own

C1KV98 (ISPH_LISMC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
EC=1.17.1.2
Gene names
Name:ispH
Ordered Locus Names:Lm4b_01461
OrganismListeria monocytogenes serotype 4b (strain Clip81459) [Complete proteome] [HAMAP]
Taxonomic identifier568819 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00191

Catalytic activity

Isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Dimethylallyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H. HAMAP MF_00191

Cofactor

Binds 1 3Fe-4S cluster By similarity. HAMAP MF_00191

Pathway

Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1. HAMAP MF_00191

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6. HAMAP MF_00191

Sequence similarities

Belongs to the IspH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3313314-hydroxy-3-methylbut-2-enyl diphosphate reductase HAMAP MF_00191
PRO_1000204008

Sequences

Sequence LengthMass (Da)Tools
C1KV98 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 0E7B02F6F8E8C7A0

FASTA33136,477
        10         20         30         40         50         60 
MEIIKISPRG YCYGVIDAMV IAKNASLDPN LPRPIHILGM IVHNKHVTDA FESIGIYTVD 

        70         80         90        100        110        120 
GANREEILDK ITTGTVIFTA HGVSPSVKAK AAAKGLTTID ATCPDVLHTY NLILEKQAAG 

       130        140        150        160        170        180 
YEIIYIGKKG HPEPEGAYGT APDVVHLVET KADIDALSLL SDNIFVTNQT TMSKWDVADL 

       190        200        210        220        230        240 
MDYIKEKFPK AIQHQEICMA TQVRQEAVAV QAKGADLTIV VGDPRSNNTA RLAQVSIEKA 

       250        260        270        280        290        300 
GTKAYRIADI TELDIEWIKD AKKVAVTAGA STPTQLVREV LLFLEQFDAA DKTTWKRAHN 

       310        320        330 
KDFERILPKM KNKYMAEKRR QRLAHLKNGG S

« Hide

References

[1]"Complete genome sequence of Listeria monocytogenes serotype 4b strain Clip81459."
Rusniok C.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Clip81459.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM242711 Genomic DNA. Translation: CAS05223.1.
RefSeqYP_002758159.1. NC_012488.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC1KV98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7704217.
GenomeReviewsGene locus Lm4b_01461 in contig FM242711_GR.
KEGGlmc:Lm4b_01461.
PATRIC20306091. VBILisMon88360_1472.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAAMAPECD.
ProtClustDBPRK01045.

Family and domain databases

HAMAPMF_00191. IspH.
[Tree]
InterProIPR003451. LytB.
[Graphical view]
KOK03527.
PfamPF02401. LYTB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00216. IspH_lytB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameISPH_LISMC
AccessionPrimary (citable) accession number: C1KV98
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents