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C1K3N5

- C1K3N5_HUMAN

UniProt

C1K3N5 - C1K3N5_HUMAN

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Protein
Submitted name:

Tumor necrosis factor alpha

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cell activation Source: Ensembl
  4. cellular extravasation Source: Ensembl
  5. cellular response to amino acid stimulus Source: Ensembl
  6. cellular response to lipopolysaccharide Source: Ensembl
  7. defense response to Gram-positive bacterium Source: Ensembl
  8. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
  9. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  10. extracellular matrix organization Source: Ensembl
  11. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  12. glucose metabolic process Source: Ensembl
  13. humoral immune response Source: Ensembl
  14. inflammatory response Source: Ensembl
  15. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  16. JNK cascade Source: Ensembl
  17. negative regulation of alkaline phosphatase activity Source: Ensembl
  18. negative regulation of cell proliferation Source: Ensembl
  19. negative regulation of glucose import Source: Ensembl
  20. negative regulation of growth of symbiont in host Source: Ensembl
  21. negative regulation of L-glutamate transport Source: Ensembl
  22. negative regulation of osteoblast differentiation Source: Ensembl
  23. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. organ morphogenesis Source: Ensembl
  25. osteoclast differentiation Source: Ensembl
  26. positive regulation of action potential Source: Ensembl
  27. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
  28. positive regulation of fever generation Source: Ensembl
  29. positive regulation of hair follicle development Source: Ensembl
  30. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  31. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  32. positive regulation of interferon-gamma production Source: Ensembl
  33. positive regulation of interleukin-18 production Source: Ensembl
  34. positive regulation of interleukin-6 production Source: Ensembl
  35. positive regulation of JNK cascade Source: Ensembl
  36. positive regulation of mitosis Source: Ensembl
  37. positive regulation of neuron apoptotic process Source: Ensembl
  38. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  39. positive regulation of protein kinase B signaling Source: Ensembl
  40. positive regulation of synaptic transmission Source: Ensembl
  41. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  42. positive regulation of translational initiation by iron Source: Ensembl
  43. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
  44. regulation of immunoglobulin secretion Source: Ensembl
  45. regulation of osteoclast differentiation Source: Ensembl
  46. regulation of protein phosphorylation Source: Ensembl
  47. regulation of reactive oxygen species metabolic process Source: Ensembl
  48. response to activity Source: Ensembl
  49. response to drug Source: Ensembl
  50. response to gold nanoparticle Source: Ensembl
  51. response to hypoxia Source: Ensembl
  52. response to radiation Source: Ensembl
  53. skeletal muscle contraction Source: Ensembl
  54. tumor necrosis factor-mediated signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alphaImported
Gene namesi
Name:TNFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: UniProtKB-KW
  3. integral component of membrane Source: Ensembl
  4. membrane raft Source: Ensembl
  5. phagocytic cup Source: Ensembl
  6. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA435.

PTM / Processingi

Proteomic databases

PRIDEiC1K3N5.

Expressioni

Gene expression databases

BgeeiC1K3N5.
ExpressionAtlasiC1K3N5. baseline and differential.

Interactioni

Family & Domainsi

Phylogenomic databases

OMAiPWYEPIY.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C1K3N5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
STESMIRDVE LAEEALPKKT GGPQGSRRCL FLSLFSFLIV AGATTLFCLL
60 70 80 90 100
HFGVIGPQRE EFPRDLSLIS PLAQAVRSSS RTPSDKPVAH VVANPQAEGQ
110 120 130 140 150
LQWLNRRANA LLANGVELRD NQLVVPSEGL YLIYSQVLFK GQGCPSTHVL
160 170 180 190 200
LTHTISRIAV SYQTKVNLLS AIKSPCQRET PEGAEAKPWY EPIYLGGVFQ
210 220 230
LEKGDRLSAE INRPDYLDFA ESGQVYFGII AL
Length:232
Mass (Da):25,513
Last modified:May 26, 2009 - v1
Checksum:i6CB7CB7AA476C8A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ795028 mRNA. Translation: ACO37640.1.
UniGeneiHs.241570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ795028 mRNA. Translation: ACO37640.1 .
UniGenei Hs.241570.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi C1K3N5.

Proteomic databases

PRIDEi C1K3N5.

Protocols and materials databases

DNASUi 7124.
Structural Biology Knowledgebase Search...

Organism-specific databases

PharmGKBi PA435.

Phylogenomic databases

OMAi PWYEPIY.

Miscellaneous databases

ChiTaRSi TNF. human.
NextBioi 27879.

Gene expression databases

Bgeei C1K3N5.
ExpressionAtlasi C1K3N5. baseline and differential.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PRINTSi PR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Guan W.J., Ma Y.H., Yu L.L., Na R.S., Liu S.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.

Entry informationi

Entry nameiC1K3N5_HUMAN
AccessioniPrimary (citable) accession number: C1K3N5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.