Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Tumor necrosis factor alpha

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor alphaImported
Gene namesi
Name:TNFImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA435.

PTM / Processingi

Proteomic databases

PRIDEiC1K3N5.

Expressioni

Gene expression databases

BgeeiC1K3N5.
GenevisibleiC1K3N5. HS.

Interactioni

Family & Domainsi

Phylogenomic databases

OMAiPWYEPIY.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C1K3N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
STESMIRDVE LAEEALPKKT GGPQGSRRCL FLSLFSFLIV AGATTLFCLL
60 70 80 90 100
HFGVIGPQRE EFPRDLSLIS PLAQAVRSSS RTPSDKPVAH VVANPQAEGQ
110 120 130 140 150
LQWLNRRANA LLANGVELRD NQLVVPSEGL YLIYSQVLFK GQGCPSTHVL
160 170 180 190 200
LTHTISRIAV SYQTKVNLLS AIKSPCQRET PEGAEAKPWY EPIYLGGVFQ
210 220 230
LEKGDRLSAE INRPDYLDFA ESGQVYFGII AL
Length:232
Mass (Da):25,513
Last modified:May 26, 2009 - v1
Checksum:i6CB7CB7AA476C8A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ795028 mRNA. Translation: ACO37640.1.
UniGeneiHs.241570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ795028 mRNA. Translation: ACO37640.1.
UniGeneiHs.241570.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiC1K3N5.

Proteomic databases

PRIDEiC1K3N5.

Protocols and materials databases

DNASUi7124.
Structural Biology KnowledgebaseSearch...

Organism-specific databases

PharmGKBiPA435.

Phylogenomic databases

OMAiPWYEPIY.

Miscellaneous databases

ChiTaRSiTNF. human.
NextBioi27879.

Gene expression databases

BgeeiC1K3N5.
GenevisibleiC1K3N5. HS.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
PR01235. TNFALPHA.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Guan W.J., Ma Y.H., Yu L.L., Na R.S., Liu S.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.

Entry informationi

Entry nameiC1K3N5_HUMAN
AccessioniPrimary (citable) accession number: C1K3N5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: June 24, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.