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C1K3N5

- C1K3N5_HUMAN

UniProt

C1K3N5 - C1K3N5_HUMAN

Protein
Submitted name:

Tumor necrosis factor alpha

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. calcium-mediated signaling Source: Ensembl
    3. cell activation Source: Ensembl
    4. cellular amino acid biosynthetic process Source: Ensembl
    5. cellular extravasation Source: Ensembl
    6. cellular response to amino acid stimulus Source: Ensembl
    7. defense response to Gram-positive bacterium Source: Ensembl
    8. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    9. extracellular matrix organization Source: Ensembl
    10. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    11. glucose metabolic process Source: Ensembl
    12. humoral immune response Source: Ensembl
    13. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    14. JNK cascade Source: Ensembl
    15. negative regulation of alkaline phosphatase activity Source: Ensembl
    16. negative regulation of cell proliferation Source: Ensembl
    17. negative regulation of glucose import Source: Ensembl
    18. negative regulation of growth of symbiont in host Source: Ensembl
    19. negative regulation of L-glutamate transport Source: Ensembl
    20. negative regulation of osteoblast differentiation Source: Ensembl
    21. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    22. organ morphogenesis Source: Ensembl
    23. osteoclast differentiation Source: Ensembl
    24. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
    25. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    26. positive regulation of fever generation Source: Ensembl
    27. positive regulation of hair follicle development Source: Ensembl
    28. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
    29. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    30. positive regulation of interferon-gamma production Source: Ensembl
    31. positive regulation of interleukin-18 production Source: Ensembl
    32. positive regulation of interleukin-6 production Source: Ensembl
    33. positive regulation of JNK cascade Source: Ensembl
    34. positive regulation of mitosis Source: Ensembl
    35. positive regulation of neuron apoptotic process Source: Ensembl
    36. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    37. positive regulation of protein kinase B signaling Source: Ensembl
    38. positive regulation of synaptic transmission Source: Ensembl
    39. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    40. positive regulation of translational initiation by iron Source: Ensembl
    41. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
    42. regulation of immunoglobulin secretion Source: Ensembl
    43. regulation of osteoclast differentiation Source: Ensembl
    44. regulation of protein phosphorylation Source: Ensembl
    45. response to activity Source: Ensembl
    46. response to drug Source: Ensembl
    47. response to hypoxia Source: Ensembl
    48. response to mechanical stimulus Source: Ensembl
    49. skeletal muscle contraction Source: Ensembl
    50. tumor necrosis factor-mediated signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    CytokineSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tumor necrosis factor alphaImported
    Gene namesi
    Name:TNFImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: UniProtKB-KW
    3. integral component of membrane Source: Ensembl
    4. membrane raft Source: Ensembl
    5. phagocytic cup Source: Ensembl
    6. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    MembraneSAAS annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA435.

    PTM / Processingi

    Proteomic databases

    PRIDEiC1K3N5.

    Expressioni

    Gene expression databases

    ArrayExpressiC1K3N5.
    BgeeiC1K3N5.

    Interactioni

    Family & Domainsi

    Phylogenomic databases

    OMAiPWYEPIY.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    C1K3N5-1 [UniParc]FASTAAdd to Basket

    « Hide

    STESMIRDVE LAEEALPKKT GGPQGSRRCL FLSLFSFLIV AGATTLFCLL    50
    HFGVIGPQRE EFPRDLSLIS PLAQAVRSSS RTPSDKPVAH VVANPQAEGQ 100
    LQWLNRRANA LLANGVELRD NQLVVPSEGL YLIYSQVLFK GQGCPSTHVL 150
    LTHTISRIAV SYQTKVNLLS AIKSPCQRET PEGAEAKPWY EPIYLGGVFQ 200
    LEKGDRLSAE INRPDYLDFA ESGQVYFGII AL 232
    Length:232
    Mass (Da):25,513
    Last modified:May 26, 2009 - v1
    Checksum:i6CB7CB7AA476C8A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ795028 mRNA. Translation: ACO37640.1.
    UniGeneiHs.241570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ795028 mRNA. Translation: ACO37640.1 .
    UniGenei Hs.241570.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi C1K3N5.

    Proteomic databases

    PRIDEi C1K3N5.

    Protocols and materials databases

    DNASUi 7124.
    Structural Biology Knowledgebase Search...

    Organism-specific databases

    PharmGKBi PA435.

    Phylogenomic databases

    OMAi PWYEPIY.

    Miscellaneous databases

    ChiTaRSi TNF. human.
    NextBioi 27879.

    Gene expression databases

    ArrayExpressi C1K3N5.
    Bgeei C1K3N5.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Guan W.J., Ma Y.H., Yu L.L., Na R.S., Liu S.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: PlacentaImported.

    Entry informationi

    Entry nameiC1K3N5_HUMAN
    AccessioniPrimary (citable) accession number: C1K3N5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.