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Protein

Major histocompatibility complex class I-related gene protein

Gene

MR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites (By similarity). Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61Pathogen-derived ligandBy similarity1

GO - Biological processi

Keywordsi

Biological processImmunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Major histocompatibility complex class I-related gene protein
Short name:
MHC class I-related gene protein
Alternative name(s):
Class I histocompatibility antigen-like protein
Gene namesi
Name:MR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Organism-specific databases

VGNCiVGNC:31595 MR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 298ExtracellularSequence analysisAdd BLAST280
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 336CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000042553119 – 336Major histocompatibility complex class I-related gene proteinAdd BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi116 ↔ 179PROSITE-ProRule annotation1 Publication
Disulfide bondi218 ↔ 274PROSITE-ProRule annotation1 Publication

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiC1ITJ8
PRIDEiC1ITJ8

Expressioni

Gene expression databases

BgeeiENSBTAG00000009924
ExpressionAtlasiC1ITJ8 baseline and differential

Interactioni

Subunit structurei

Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3.2 Publications

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013095

Structurei

Secondary structure

1336
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 30Combined sources10
Beta strandi39 – 46Combined sources8
Beta strandi49 – 58Combined sources10
Beta strandi63 – 65Combined sources3
Helixi66 – 69Combined sources4
Helixi74 – 101Combined sources28
Beta strandi109 – 118Combined sources10
Beta strandi120 – 122Combined sources3
Beta strandi124 – 132Combined sources9
Beta strandi135 – 141Combined sources7
Turni142 – 145Combined sources4
Beta strandi146 – 153Combined sources8
Helixi154 – 163Combined sources10
Helixi165 – 176Combined sources12
Helixi178 – 189Combined sources12
Helixi191 – 194Combined sources4
Beta strandi201 – 206Combined sources6
Beta strandi215 – 226Combined sources12
Beta strandi229 – 234Combined sources6
Beta strandi241 – 245Combined sources5
Beta strandi252 – 254Combined sources3
Beta strandi256 – 263Combined sources8
Beta strandi272 – 280Combined sources9
Beta strandi282 – 288Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IIQX-ray2.86C19-295[»]
4L8SX-ray2.90C19-295[»]
4L9LX-ray3.40C19-295[»]
4LCCX-ray3.26C19-295[»]
ProteinModelPortaliC1ITJ8
SMRiC1ITJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 295Ig-like C1-typeAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 197Ligand-bindingBy similarityAdd BLAST179
Regioni19 – 105Alpha-1Add BLAST87
Regioni106 – 197Alpha-2Add BLAST92
Regioni198 – 289Alpha-3Add BLAST92
Regioni290 – 298Connecting peptideBy similarity9

Domaini

The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression (By similarity). The alpha-3 region mediates interaction with B2M.By similarity
The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides.By similarity

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00740000114936
HOGENOMiHOG000296917
InParanoidiC1ITJ8
OMAiGYVDSHP
OrthoDBiEOG091G0K1X
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C1ITJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLLLPLIIV LMMKLSDART HSLRYFRLGI SEPGYGIPEF ISAGYVDSHP
60 70 80 90 100
ITMYNSVSQL KEPRALWMEE NLAPDHWERY TQLLRGWQQA FKVELKQLQH
110 120 130 140 150
HYNHSGFHTY QRMIGCELLE DGSITGFLQY AYDGQDFLIF NKDTLSWMAM
160 170 180 190 200
DNVADIIRRV WEANRHELQY QKNWLEEECI AWLKRFLEYG KDALQRTEPP
210 220 230 240 250
KVRVNHKETF PGITTLYCRA YGFYPPEISI NWMKNGEEIF QDTDYGGILP
260 270 280 290 300
SGDGTYQTWV SVELDPQNGD IYSCHVEHGG VHMVLQGFQE SETILLVVKA
310 320 330
VGFIVLAIAL AGVGILAWRK RPRGKNKVIC LSTPEH
Length:336
Mass (Da):38,894
Last modified:May 26, 2009 - v1
Checksum:iD0501CC96F59A2C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU792881 mRNA Translation: ACH56827.1
FJ028657 mRNA Translation: ACN18277.1
DAAA02043522 Genomic DNA No translation available.
DAAA02043523 Genomic DNA No translation available.
RefSeqiNP_001177227.1, NM_001190298.1
UniGeneiBt.63045

Genome annotation databases

EnsembliENSBTAT00000013095; ENSBTAP00000013095; ENSBTAG00000009924
GeneIDi506206
KEGGibta:506206

Similar proteinsi

Entry informationi

Entry nameiHMR1_BOVIN
AccessioniPrimary (citable) accession number: C1ITJ8
Secondary accession number(s): F1MVL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health