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C1ITJ8

- HMR1_BOVIN

UniProt

C1ITJ8 - HMR1_BOVIN

Protein

Major histocompatibility complex class I-related gene protein

Gene

MR1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites By similarity. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611Pathogen-derived ligandBy similarity

    GO - Molecular functioni

    1. peptide antigen binding Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    2. cytokine production involved in immune response Source: Ensembl
    3. defense response to Gram-negative bacterium Source: Ensembl
    4. innate immune response Source: UniProtKB-KW
    5. interleukin-17 production Source: Ensembl
    6. interleukin-1 beta production Source: Ensembl
    7. positive regulation of T cell mediated cytotoxicity Source: InterPro

    Keywords - Biological processi

    Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major histocompatibility complex class I-related gene protein
    Short name:
    MHC class I-related gene protein
    Alternative name(s):
    Class I histocompatibility antigen-like protein
    Gene namesi
    Name:MR1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 16

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity; Extracellular side By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. MHC class I protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Membrane, MHC I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 336318Major histocompatibility complex class I-related gene proteinPRO_0000425531Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi103 – 1031N-linked (GlcNAc...)Curated
    Disulfide bondi116 ↔ 1791 PublicationPROSITE-ProRule annotation
    Disulfide bondi218 ↔ 2741 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3.2 Publications

    Structurei

    Secondary structure

    1
    336
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi21 – 3010
    Beta strandi39 – 468
    Beta strandi49 – 5810
    Beta strandi63 – 653
    Helixi66 – 694
    Helixi74 – 10128
    Beta strandi109 – 11810
    Beta strandi120 – 1223
    Beta strandi124 – 1329
    Beta strandi135 – 1417
    Turni142 – 1454
    Beta strandi146 – 1538
    Helixi154 – 16310
    Helixi165 – 17612
    Helixi178 – 18912
    Helixi191 – 1944
    Beta strandi201 – 2066
    Beta strandi215 – 22612
    Beta strandi229 – 2346
    Beta strandi243 – 2508
    Beta strandi252 – 2543
    Beta strandi256 – 2638
    Beta strandi272 – 2809
    Beta strandi282 – 2887

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IIQX-ray2.86C19-295[»]
    4L8SX-ray2.90C19-295[»]
    4L9LX-ray3.40C19-295[»]
    4LCCX-ray3.26C19-295[»]
    ProteinModelPortaliC1ITJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 298280ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini320 – 33617CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei299 – 31921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini199 – 29597Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 197179Ligand-bindingBy similarityAdd
    BLAST
    Regioni19 – 10587Alpha-1Add
    BLAST
    Regioni106 – 19792Alpha-2Add
    BLAST
    Regioni198 – 28992Alpha-3Add
    BLAST
    Regioni290 – 2989Connecting peptideBy similarity

    Domaini

    The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression By similarity. The alpha-3 region mediates interaction with B2M.By similarity
    The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides.By similarity

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00750000117285.
    HOGENOMiHOG000296917.
    OMAiREANQHE.
    TreeFamiTF336617.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C1ITJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLLLPLIIV LMMKLSDART HSLRYFRLGI SEPGYGIPEF ISAGYVDSHP    50
    ITMYNSVSQL KEPRALWMEE NLAPDHWERY TQLLRGWQQA FKVELKQLQH 100
    HYNHSGFHTY QRMIGCELLE DGSITGFLQY AYDGQDFLIF NKDTLSWMAM 150
    DNVADIIRRV WEANRHELQY QKNWLEEECI AWLKRFLEYG KDALQRTEPP 200
    KVRVNHKETF PGITTLYCRA YGFYPPEISI NWMKNGEEIF QDTDYGGILP 250
    SGDGTYQTWV SVELDPQNGD IYSCHVEHGG VHMVLQGFQE SETILLVVKA 300
    VGFIVLAIAL AGVGILAWRK RPRGKNKVIC LSTPEH 336
    Length:336
    Mass (Da):38,894
    Last modified:May 26, 2009 - v1
    Checksum:iD0501CC96F59A2C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU792881 mRNA. Translation: ACH56827.1.
    FJ028657 mRNA. Translation: ACN18277.1.
    DAAA02043522 Genomic DNA. No translation available.
    DAAA02043523 Genomic DNA. No translation available.
    RefSeqiNP_001177227.1. NM_001190298.1.
    UniGeneiBt.63045.

    Genome annotation databases

    EnsembliENSBTAT00000013095; ENSBTAP00000013095; ENSBTAG00000009924.
    GeneIDi506206.
    KEGGibta:506206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU792881 mRNA. Translation: ACH56827.1 .
    FJ028657 mRNA. Translation: ACN18277.1 .
    DAAA02043522 Genomic DNA. No translation available.
    DAAA02043523 Genomic DNA. No translation available.
    RefSeqi NP_001177227.1. NM_001190298.1.
    UniGenei Bt.63045.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IIQ X-ray 2.86 C 19-295 [» ]
    4L8S X-ray 2.90 C 19-295 [» ]
    4L9L X-ray 3.40 C 19-295 [» ]
    4LCC X-ray 3.26 C 19-295 [» ]
    ProteinModelPortali C1ITJ8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000013095 ; ENSBTAP00000013095 ; ENSBTAG00000009924 .
    GeneIDi 506206.
    KEGGi bta:506206.

    Organism-specific databases

    CTDi 3140.

    Phylogenomic databases

    GeneTreei ENSGT00750000117285.
    HOGENOMi HOG000296917.
    OMAi REANQHE.
    TreeFami TF336617.

    Miscellaneous databases

    NextBioi 20867500.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution."
      Huang S., Martin E., Kim S., Yu L., Soudais C., Fremont D.H., Lantz O., Hansen T.H.
      Proc. Natl. Acad. Sci. U.S.A. 106:8290-8295(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT.
    2. "Ruminant MR1 and MAIT cells."
      Van Rhijn I.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.
    4. Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 19-295 IN COMPLEX WITH B2M AND HUMAN T-CELL RECEPTOR, DISULFIDE BONDS.

    Entry informationi

    Entry nameiHMR1_BOVIN
    AccessioniPrimary (citable) accession number: C1ITJ8
    Secondary accession number(s): F1MVL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 19, 2014
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3