SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C1ITJ8

- HMR1_BOVIN

UniProt

C1ITJ8 - HMR1_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Major histocompatibility complex class I-related gene protein
Gene
MR1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites By similarity. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Pathogen-derived ligand By similarity

GO - Molecular functioni

  1. antigen binding Source: RefGenome
  2. peptide antigen binding Source: InterPro

GO - Biological processi

  1. antigen processing and presentation Source: RefGenome
  2. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  3. cytokine production involved in immune response Source: Ensembl
  4. defense response to Gram-negative bacterium Source: Ensembl
  5. innate immune response Source: UniProtKB-KW
  6. interleukin-1 beta production Source: Ensembl
  7. interleukin-17 production Source: Ensembl
  8. positive regulation of T cell mediated cytotoxicity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Major histocompatibility complex class I-related gene protein
Short name:
MHC class I-related gene protein
Alternative name(s):
Class I histocompatibility antigen-like protein
Gene namesi
Name:MR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 298280Extracellular Reviewed prediction
Add
BLAST
Transmembranei299 – 31921Helical; Reviewed prediction
Add
BLAST
Topological domaini320 – 33617Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. MHC class I protein complex Source: UniProtKB-KW
  2. endoplasmic reticulum Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarity
Add
BLAST
Chaini19 – 336318Major histocompatibility complex class I-related gene protein
PRO_0000425531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...) Inferred
Disulfide bondi116 ↔ 1791 Publication
Disulfide bondi218 ↔ 2741 Publication

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3.1 Publication

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 3010
Beta strandi39 – 468
Beta strandi49 – 5810
Beta strandi63 – 653
Helixi66 – 694
Helixi74 – 10128
Beta strandi109 – 11810
Beta strandi120 – 1223
Beta strandi124 – 1329
Beta strandi135 – 1417
Turni142 – 1454
Beta strandi146 – 1538
Helixi154 – 16310
Helixi165 – 17612
Helixi178 – 18912
Helixi191 – 1944
Beta strandi201 – 2066
Beta strandi215 – 22612
Beta strandi229 – 2346
Beta strandi243 – 2508
Beta strandi252 – 2543
Beta strandi256 – 2638
Beta strandi272 – 2809
Beta strandi282 – 2887

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IIQX-ray2.86C19-295[»]
4L8SX-ray2.90C19-295[»]
4L9LX-ray3.40C19-295[»]
4LCCX-ray3.26C19-295[»]
ProteinModelPortaliC1ITJ8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 29597Ig-like C1-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 197179Ligand-binding By similarity
Add
BLAST
Regioni19 – 10587Alpha-1
Add
BLAST
Regioni106 – 19792Alpha-2
Add
BLAST
Regioni198 – 28992Alpha-3
Add
BLAST
Regioni290 – 2989Connecting peptide By similarity

Domaini

The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression By similarity. The alpha-3 region mediates interaction with B2M.
The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides By similarity.

Sequence similaritiesi

Belongs to the MHC class I family.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00750000117285.
HOGENOMiHOG000296917.
OMAiREANQHE.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C1ITJ8-1 [UniParc]FASTAAdd to Basket

« Hide

MMLLLPLIIV LMMKLSDART HSLRYFRLGI SEPGYGIPEF ISAGYVDSHP    50
ITMYNSVSQL KEPRALWMEE NLAPDHWERY TQLLRGWQQA FKVELKQLQH 100
HYNHSGFHTY QRMIGCELLE DGSITGFLQY AYDGQDFLIF NKDTLSWMAM 150
DNVADIIRRV WEANRHELQY QKNWLEEECI AWLKRFLEYG KDALQRTEPP 200
KVRVNHKETF PGITTLYCRA YGFYPPEISI NWMKNGEEIF QDTDYGGILP 250
SGDGTYQTWV SVELDPQNGD IYSCHVEHGG VHMVLQGFQE SETILLVVKA 300
VGFIVLAIAL AGVGILAWRK RPRGKNKVIC LSTPEH 336
Length:336
Mass (Da):38,894
Last modified:May 26, 2009 - v1
Checksum:iD0501CC96F59A2C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU792881 mRNA. Translation: ACH56827.1.
FJ028657 mRNA. Translation: ACN18277.1.
DAAA02043522 Genomic DNA. No translation available.
DAAA02043523 Genomic DNA. No translation available.
RefSeqiNP_001177227.1. NM_001190298.1.
UniGeneiBt.63045.

Genome annotation databases

EnsembliENSBTAT00000013095; ENSBTAP00000013095; ENSBTAG00000009924.
GeneIDi506206.
KEGGibta:506206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU792881 mRNA. Translation: ACH56827.1 .
FJ028657 mRNA. Translation: ACN18277.1 .
DAAA02043522 Genomic DNA. No translation available.
DAAA02043523 Genomic DNA. No translation available.
RefSeqi NP_001177227.1. NM_001190298.1.
UniGenei Bt.63045.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IIQ X-ray 2.86 C 19-295 [» ]
4L8S X-ray 2.90 C 19-295 [» ]
4L9L X-ray 3.40 C 19-295 [» ]
4LCC X-ray 3.26 C 19-295 [» ]
ProteinModelPortali C1ITJ8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000013095 ; ENSBTAP00000013095 ; ENSBTAG00000009924 .
GeneIDi 506206.
KEGGi bta:506206.

Organism-specific databases

CTDi 3140.

Phylogenomic databases

GeneTreei ENSGT00750000117285.
HOGENOMi HOG000296917.
OMAi REANQHE.
TreeFami TF336617.

Miscellaneous databases

NextBioi 20867500.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution."
    Huang S., Martin E., Kim S., Yu L., Soudais C., Fremont D.H., Lantz O., Hansen T.H.
    Proc. Natl. Acad. Sci. U.S.A. 106:8290-8295(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT.
  2. "Ruminant MR1 and MAIT cells."
    Van Rhijn I.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  4. Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 19-295 IN COMPLEX WITH B2M AND HUMAN T-CELL RECEPTOR, DISULFIDE BONDS.

Entry informationi

Entry nameiHMR1_BOVIN
AccessioniPrimary (citable) accession number: C1ITJ8
Secondary accession number(s): F1MVL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 19, 2014
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi