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Protein

Ubiquitin-like protein ATG12

Gene

ATG12

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Ubiquitin-like protein involved in autophagic vesicle formation.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

AutophagyUniRule annotation, Ubl conjugation pathwayUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein ATG12UniRule annotation
Gene namesi
Name:ATG12Imported
ORF Names:hCG_36968Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Keywords - PTMi

Isopeptide bondUniRule annotation

Proteomic databases

MaxQBiC1IDX9.

Expressioni

Gene expression databases

BgeeiENSG00000145782.

Interactioni

Subunit structurei

Forms a conjugate with ATG5.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000425107.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG12 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3439. Eukaryota.
ENOG4111ND7. LUCA.
HOGENOMiHOG000234863.
PhylomeDBiC1IDX9.

Family and domain databases

CDDicd01612. APG12_C. 1 hit.
InterProiIPR007242. Atg12.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR13385. PTHR13385. 1 hit.
PfamiPF04110. APG12. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

C1IDX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSREHQVSL CNCVPLLRRL LCDAPWRKAR PLHALSRYFR SRVSPSKMAE
60 70 80 90 100
EPQSVLQLPT SIAAGGEGLT DVSPETTTPE PPSSAAVSPG TEEPAGDTKK
110 120 130 140 150
KIDILLKAVG DTPIMKTKKW AVERTRTIQG LIDFIKKFLK LVASEQLFIY
160 170 180
VNQSFAPSPD QEVGTLYECF GSDGKLVLHY CKSQAWG
Length:187
Mass (Da):20,632
Last modified:May 26, 2009 - v1
Checksum:i0D7473DFE5E2EB1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU554057 mRNA. Translation: ACD74941.1.
CH471086 Genomic DNA. Translation: EAW48955.1.
CH471086 Genomic DNA. Translation: EAW48956.1.
UniGeneiHs.264482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU554057 mRNA. Translation: ACD74941.1.
CH471086 Genomic DNA. Translation: EAW48955.1.
CH471086 Genomic DNA. Translation: EAW48956.1.
UniGeneiHs.264482.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000425107.

Proteomic databases

MaxQBiC1IDX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3439. Eukaryota.
ENOG4111ND7. LUCA.
HOGENOMiHOG000234863.
PhylomeDBiC1IDX9.

Miscellaneous databases

ChiTaRSiATG12. human.

Gene expression databases

BgeeiENSG00000145782.

Family and domain databases

CDDicd01612. APG12_C. 1 hit.
InterProiIPR007242. Atg12.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR13385. PTHR13385. 1 hit.
PfamiPF04110. APG12. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC1IDX9_HUMAN
AccessioniPrimary (citable) accession number: C1IDX9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.