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C1HAB2

- MAP2_PARBA

UniProt

C1HAB2 - MAP2_PARBA

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Protein

Methionine aminopeptidase 2

Gene

PAAG_07566

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei195 – 1951SubstrateUniRule annotation
Metal bindingi215 – 2151Divalent metal cation 1UniRule annotation
Metal bindingi226 – 2261Divalent metal cation 1UniRule annotation
Metal bindingi226 – 2261Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi295 – 2951Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
Binding sitei303 – 3031SubstrateUniRule annotation
Metal bindingi331 – 3311Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi426 – 4261Divalent metal cation 1UniRule annotation
Metal bindingi426 – 4261Divalent metal cation 2; catalyticUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2UniRule annotation
Short name:
MetAP 2UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:PAAG_07566
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000002059: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Methionine aminopeptidase 2PRO_0000407659Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC1HAB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 7316Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1HAB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAQVASGVG NLNLNSEGGA AAKNRPAQGS PENEARESDG EYDDDQGAPE
60 70 80 90 100
LGNTTAAKKK KKKTKKKKKC TSKVQTEPPR IILSSLFPNN QYPEGEIVEY
110 120 130 140 150
QNENAYRTTN EEKRHLDRMN NDFLAEYRYA AEVHRQVRQY SQKAIKPGQT
160 170 180 190 200
LTEIAEGIEE SVRALTGHPG LEEGDNLRGG IAFPTGVNLN HCAAHYTPNA
210 220 230 240 250
GNKMVLQYED VMKVDFGVHI NGRIVDSAFT IAFDPVYDNL LAAVKDATNT
260 270 280 290 300
GIKQAGIDVR MSDIGAAIQE AMESYEVEIK GTSYPVKAIR NLNGHTIGRY
310 320 330 340 350
EIHGGKNGKS VPIVKGGDQT KMEEGEVYAI ETFGSTGRGY VRDDMETSHY
360 370 380 390 400
AKIPDAPNVP LRLSSAKNLL NVITKNFGTL PFCRRYLDRL GQDKYLLGLN
410 420 430 440
NLVANGIVDA YPPLCDVKGS YTAQFEHTIL LRPNVKEIIS RGDDY
Length:445
Mass (Da):48,945
Last modified:May 26, 2009 - v1
Checksum:i9842168F931D0254
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS572836 Genomic DNA. Translation: EEH37285.1.
RefSeqiXP_002790267.1. XM_002790221.1.

Genome annotation databases

GeneIDi9093508.
KEGGipbl:PAAG_07566.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS572836 Genomic DNA. Translation: EEH37285.1 .
RefSeqi XP_002790267.1. XM_002790221.1.

3D structure databases

ProteinModelPortali C1HAB2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9093508.
KEGGi pbl:PAAG_07566.

Phylogenomic databases

KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-826 / Pb01.

Entry informationi

Entry nameiMAP2_PARBA
AccessioniPrimary (citable) accession number: C1HAB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3