C1H978 (AMPP1_PARBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	PAAG_07319

Organism

Paracoccidioides brasiliensis (strain ATCC MYA-826 / Pb01) [Complete proteome]

Taxonomic identifier

502779 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Paracoccidioides › Paracoccidioides sp. 'lutzii'

Protein attributes

Sequence length	698 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 698	698	Probable Xaa-Pro aminopeptidase P		PRO_0000411800
Sites
	Metal binding	483	1	Manganese 2 By similarity
	Metal binding	494	1	Manganese 1 By similarity
	Metal binding	494	1	Manganese 2 By similarity
	Metal binding	604	1	Manganese 1 By similarity
	Metal binding	618	1	Manganese 1 By similarity
	Metal binding	618	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1H978 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 698770A46C05E493	FASTA	698	77,762
	10 20 30 40 50 60 MNIRLLLVII SSVTPNALLT HTTGLAGQNL DSELSFPPAF YLHLAKSHIN LIRDYDKCCF 70 80 90 100 110 120 SVIPERQSAD METVDTSQRL ACLRELMKER KVDVYLVPSE DSHQSEYIAP CDGRREFISG 130 140 150 160 170 180 FSGSAGCAIV SMTKAALSTD GRYFNQASKQ LDNNWLLLKR GIESMPTWQE WTAEQLEGGK 190 200 210 220 230 240 VVGVDPSLIT ASDARSLSET IKKSGGSLLG LQENLVDLVW GKDRPSRPSK KVTVHPVEFA 250 260 270 280 290 300 GKSFEEKITD LRKELEKKKS AGFVVSMLDE IAWLFNLRGN DIPYNPVFFA YAIITPSTAD 310 320 330 340 350 360 LYIDEDKLSA DVKKHLGDKV SLKPYTSIFE DAKALGQSAQ AEVNGGASDP PRKFFISTKA 370 380 390 400 410 420 SWSLSLALGG ENKVEEVRSP ISDAKAIKND AELEGMRACH IRDGAALTKY FAWLENELLN 430 440 450 460 470 480 KKTVLNEVEA SDKLEEIRSK QKNFVGLSFD TISSSGPNAA VIHYKAERNN CSIIDPEAVY 490 500 510 520 530 540 LCDSGAQYLD GTTDTTRTLH FGEPTEKERK AYTLVLKGMI AIDTAIFPKG TTGFSLDTFA 550 560 570 580 590 600 RQFLWKEGLD YLHGTGHGVG SYLASQELTD YKNVHEGPIG IGTRVQYSEV PISAGNVISD 610 620 630 640 650 660 DLLEPGFYED GNFGIRIENI IMAREVKTTF SFGERPWLGF EHVTMTPLCR KLTDPSLLSD 670 680 690 AEKIWINEYH NEVWEKTSGY FEEDELTRNW LKRETQPI

References

[1]

"Annotation of Paracoccidioides brasiliensis Pb01." McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Ma L.-J.J., Henn M.R., Champion M., Cuomo C., Jaffe D.B., Young S.K., Gnerre S., Berlin A., Heiman D., Hepburn T., Sykes S., Yandava C., Alvarado L., Kodira C.D. , Guigo R., Borodovsky M., Goldman B., Klein B., Mendoza L., Nino-Vega G., San-Blas G., Sil A., de Almeida Soares C.M., Taylor J., Lander E.S., Nusbaum C., Galagan J.E., Birren B.W. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-826 / Pb01.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS572833 Genomic DNA. Translation: EEH36901.1.
RefSeq	XP_002790782.1. XM_002790736.1.
3D structure databases
ProteinModelPortal	C1H978.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9094019.
KEGG	pbl:PAAG_07319.
Phylogenomic databases
KO	K01262.
OrthoDB	EOG45F0XX.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_PARBA

Accession

Primary (citable) accession number: C1H978

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	May 26, 2009
Last modified:	March 6, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program