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C1H594

- LIPA_PARBA

UniProt

C1H594 - LIPA_PARBA

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Protein
Lipoyl synthase, mitochondrial
Gene
PAAG_05935
Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi150 – 1501Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi155 – 1551Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi161 – 1611Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi181 – 1811Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi185 – 1851Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi188 – 1881Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrial (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
ORF Names:PAAG_05935
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000002059: Unassembled WGS sequence

Subcellular locationi

Mitochondrion Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737Mitochondrion Reviewed prediction
Add
BLAST
Chaini38 – 439402Lipoyl synthase, mitochondrialUniRule annotation
PRO_0000398276Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC1H594.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK03644.
OrthoDBiEOG79KPR7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C1H594-1 [UniParc]FASTAAdd to Basket

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MVASARGLRT LHSAHSSISA LPASTVPRLQ LAVSRCYATT TSPDCPITNS    50
SNSSNSTPTL TPKQRITAFK DKLNAGPSFS DFVSGGGASN DSVPLDPTEA 100
YSLKTALVGP PGKKKQIIRL PSWLKTPIPD SPNFRRIKSD LRGLNLHTVC 150
EEARCPNISD CWGGSSKSAA TATIMLMGDT CTRGCRFCSV KTSRTPPPLD 200
PHEPENTAEA LSRWGLGYVV MTSVDRDDLA DGGARHVAET VRKVKQKAPN 250
ILLECLTGDY AGDLEMVALV ATSGLDVFAH NVETVEALTP FVRDRRATFQ 300
QSLRVLKAAK EAKPELITKT SIMLGLGETE AQLWETLKAL RAVDVDVVTF 350
GQYMRPTKRH MAVHEYVRPD VFDSWKERAL EMGFLYCASG PLVRSSYKAG 400
EAFIENVLKK RRGEGADGSG GSSTRREDVE RLVAGGVVR 439
Length:439
Mass (Da):47,567
Last modified:May 26, 2009 - v1
Checksum:i3BAB21D357F78492
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572826 Genomic DNA. Translation: EEH34888.1.
RefSeqiXP_002792147.1. XM_002792101.1.

Genome annotation databases

GeneIDi9095385.
KEGGipbl:PAAG_05935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572826 Genomic DNA. Translation: EEH34888.1 .
RefSeqi XP_002792147.1. XM_002792101.1.

3D structure databases

ProteinModelPortali C1H594.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9095385.
KEGGi pbl:PAAG_05935.

Phylogenomic databases

KOi K03644.
OrthoDBi EOG79KPR7.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-826 / Pb01.

Entry informationi

Entry nameiLIPA_PARBA
AccessioniPrimary (citable) accession number: C1H594
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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