ID   C1H3K6_PARBA            Unreviewed;       562 AA.
AC   C1H3K6;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Alpha-amylase {ECO:0000313|EMBL:EEH34300.2};
GN   ORFNames=PAAG_05349 {ECO:0000313|EMBL:EEH34300.2};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:EEH34300.2, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:EEH34300.2, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC       {ECO:0000256|ARBA:ARBA00008061}.
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DR   EMBL; KN294005; EEH34300.2; -; Genomic_DNA.
DR   RefSeq; XP_015699774.1; XM_015845548.1.
DR   AlphaFoldDB; C1H3K6; -.
DR   STRING; 502779.C1H3K6; -.
DR   GeneID; 9096033; -.
DR   KEGG; pbl:PAAG_05349; -.
DR   VEuPathDB; FungiDB:PAAG_05349; -.
DR   eggNOG; KOG0471; Eukaryota.
DR   HOGENOM; CLU_024572_2_0_1; -.
DR   OMA; HPFGLAC; -.
DR   OrthoDB; 2728918at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd11318; AmyAc_bac_fung_AmyA; 1.
DR   Gene3D; 2.40.30.140; -; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR013776; A-amylase_thermo.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR43447; ALPHA-AMYLASE; 1.
DR   PANTHER; PTHR43447:SF49; ALPHA-AMYLASE; 1.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   PIRSF; PIRSF001021; Alph-amls_thrmst; 1.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT   DOMAIN          36..427
FT                   /note="Glycosyl hydrolase family 13 catalytic"
FT                   /evidence="ECO:0000259|SMART:SM00642"
SQ   SEQUENCE   562 AA;  64016 MW;  E3C64C75E4B89DDE CRC64;
     MASFIVSAYK YIFRRKKTKW LDIEDFNTDN PGEENKLMFQ AFEWFVPNDK KHWQRLQAAL
     PSLKAIGVTS IWLPPGCKAM HPSGNGYDIY DLYDLGEFNQ KGTKATKWGT KEELVSLVTK
     AHEMEIAVYW DAVLNHKAAA DYVEKCVAVM VDPKDLDRRR VISEPQEIEA WSGFSFPGRG
     NQYSKMKYHS EHFTGVDYDA HTGRNGIFKI LGPKNKDWAR DVSNENGNYD YLMFADLDHS
     NPEVREDIKR WIEWLGDQLH ISGLRFDAAK HYSAGFLRDF IIHIQQTVGA GWFFVAEYWK
     AEVWELLNYL GRMGYLVSLF DAPLVHQFSY ISTTEGADLR RVFEGSLVKY KQKHAVTFVM
     NHDTQPSQSL EVPIAEFFKP LAYSLILLRR EGYPCLFYGD LYGLCGGCEG ILRPSCNGQL
     ANLSLARKLY AYGQQRDYFN KRNCIATKTP HQVPSSITVN MSLSGFVRMG DSAHPHGLAC
     VLSNGPADTK RMNVGKSHAG SVWTEVYGSC RSKVTIDRRG YGIFGVVSYS VSVWVREDAT
     GRDSFGKLYV DFLFVSIFPL LN
//