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Protein

Histone-lysine N-methyltransferase

Gene

PAAG_04957

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotationImported, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:PAAG_04957Imported
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)Imported
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisParacoccidioides
Proteomesi
  • UP000002059 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PAAG_04957

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi502779.XP_002793428.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 203AWSInterPro annotationAdd BLAST56
Domaini205 – 322SETInterPro annotationAdd BLAST118
Domaini329 – 345Post-SETInterPro annotationAdd BLAST17
Domaini602 – 633WWInterPro annotationAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili826 – 846Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4442 Eukaryota
COG2940 LUCA
KOiK11423
OrthoDBiEOG092C3T9B

Family and domain databases

Gene3Di1.10.1740.100, 1 hit
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR025788 Hist-Lys_N-MeTrfase_SET2_fun
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013257 SRI
IPR038190 SRI_sf
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF08236 SRI, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS51568 SAM_MT43_SET2_1, 1 hit
PS50280 SET, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

C1H221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHDDDDIQ PEAVADAVTA LKIKRDNSAE STPIDSTHAS DSANYYPNGF
60 70 80 90 100
SKSSPTKSIS QEQKSQSGSN SPAAKVENGQ PEEKLPVSIT VKLEPGQPPK
110 120 130 140 150
LSRVGSQKVV PQPAPLFDHL PDSTAEATST FQVIDDCTYA NKYMGYTEHA
160 170 180 190 200
MECDCSEEWD PVAGKNGACG EDSDCINRAT KMECVGDCGC GDECQNQRFQ
210 220 230 240 250
RRQYANVTVI KTEKKGYGLR ADSDLRPHQF IFEYIGEVIN EASFRKRMIA
260 270 280 290 300
YDEEGIKHFY FMSLTKGEFV DATKKGNLGR FCNHSCNPNC YVDKWVVGEK
310 320 330 340 350
LRMGIFAERH IKAGEELVFN YNVDRYGADP QPCYCGEPNC TGFIGGKTQT
360 370 380 390 400
ERATKLSNAT IEALGIDDPD GWDTAVAKRP RKKKTGEDDE EYVDSMQPRS
410 420 430 440 450
LNEDGVTKVM AALMQCKEKW IAVKLLGRIQ RCDDERVRNR VVKMHGYQIL
460 470 480 490 500
NSQLSAWKDD FNVVLQILDI LDKFPRLTRN KIIDSKIEVT IKPLTGCGDE
510 520 530 540 550
RVEKKAAALL QIWSTLEIGY RIPRMKRDPT ASNNTTAVNR FERRESSRND
560 570 580 590 600
ENQKPRSKSR SRSRSRSIDA PRAPAALRNG KGPPRNSYHH GPRPFRRPPF
610 620 630 640 650
ANPLPQGWFA AESNGKTYYY SASGATTWKR PTAPAPQPPP PPKPESKDKA
660 670 680 690 700
LQDIIDGIMN AKENTPKTRD KSETPATSQP RDAKPPEIKE HKEKWRSYSE
710 720 730 740 750
EKQKRLYENT IFPHVKYVMD KFKHKLPKEE LKRYAKEVGK KLVNSDFKNH
760 770 780 790 800
RVDDPTKVSD KQIKQIKRYC KEYFDKAVAK HLAYEKKKAE RKAREAAKVT
810 820 830 840 850
EGGSRDATEN PELSQQPEIR DSKKEESDVE EDIKMSDDEM DKLEDKKSSP
860 870 880 890 900
MSLDENSLKR KRDADGNLDV DVDTAGASPS KRTKSSTPPP PPPPPIDMCE
910 920 930 940 950
DVARDSHKRK RDEGGDNGYG TNSFSPGKRT RSESPPPPPP PPPPADTSEM
960 970 980 990 1000
CDAGEDQSRG DEEFGIDENT DVNMSSLSSA TPLDHENANR APGKDLNGTL
1010 1020
EQQLSLDAFH SLPDETNKVA VDVEYCSS
Length:1,028
Mass (Da):115,262
Last modified:February 4, 2015 - v2
Checksum:i991B007C5F673D0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN294003 Genomic DNA Translation: EEH33908.2
RefSeqiXP_015699648.1, XM_015845422.1

Genome annotation databases

EnsemblFungiiEEH33908; EEH33908; PAAG_04957
GeneIDi9096397
KEGGipbl:PAAG_04957

Similar proteinsi

Entry informationi

Entry nameiC1H221_PARBA
AccessioniPrimary (citable) accession number: C1H221
Entry historyiIntegrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: February 4, 2015
Last modified: March 28, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health