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Protein

Histone-lysine N-methyltransferase

Gene

PAAG_04957

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
ORF Names:PAAG_04957Imported
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)Imported
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000002059: Partially assembled WGS

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Phylogenomic databases

KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1H221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHDDDDIQ PEAVADAVTA LKIKRDNSAE STPIDSTHAS DSANYYPNGF
60 70 80 90 100
SKSSPTKSIS QEQKSQSGSN SPAAKVENGQ PEEKLPVSIT VKLEPGQPPK
110 120 130 140 150
LSRVGSQKVV PQPAPLFDHL PDSTAEATST FQVIDDCTYA NKYMGYTEHA
160 170 180 190 200
MECDCSEEWD PVAGKNGACG EDSDCINRAT KMECVGDCGC GDECQNQRFQ
210 220 230 240 250
RRQYANVTVI KTEKKGYGLR ADSDLRPHQF IFEYIGEVIN EASFRKRMIA
260 270 280 290 300
YDEEGIKHFY FMSLTKGEFV DATKKGNLGR FCNHSCNPNC YVDKWVVGEK
310 320 330 340 350
LRMGIFAERH IKAGEELVFN YNVDRYGADP QPCYCGEPNC TGFIGGKTQT
360 370 380 390 400
ERATKLSNAT IEALGIDDPD GWDTAVAKRP RKKKTGEDDE EYVDSMQPRS
410 420 430 440 450
LNEDGVTKVM AALMQCKEKW IAVKLLGRIQ RCDDERVRNR VVKMHGYQIL
460 470 480 490 500
NSQLSAWKDD FNVVLQILDI LDKFPRLTRN KIIDSKIEVT IKPLTGCGDE
510 520 530 540 550
RVEKKAAALL QIWSTLEIGY RIPRMKRDPT ASNNTTAVNR FERRESSRND
560 570 580 590 600
ENQKPRSKSR SRSRSRSIDA PRAPAALRNG KGPPRNSYHH GPRPFRRPPF
610 620 630 640 650
ANPLPQGWFA AESNGKTYYY SASGATTWKR PTAPAPQPPP PPKPESKDKA
660 670 680 690 700
LQDIIDGIMN AKENTPKTRD KSETPATSQP RDAKPPEIKE HKEKWRSYSE
710 720 730 740 750
EKQKRLYENT IFPHVKYVMD KFKHKLPKEE LKRYAKEVGK KLVNSDFKNH
760 770 780 790 800
RVDDPTKVSD KQIKQIKRYC KEYFDKAVAK HLAYEKKKAE RKAREAAKVT
810 820 830 840 850
EGGSRDATEN PELSQQPEIR DSKKEESDVE EDIKMSDDEM DKLEDKKSSP
860 870 880 890 900
MSLDENSLKR KRDADGNLDV DVDTAGASPS KRTKSSTPPP PPPPPIDMCE
910 920 930 940 950
DVARDSHKRK RDEGGDNGYG TNSFSPGKRT RSESPPPPPP PPPPADTSEM
960 970 980 990 1000
CDAGEDQSRG DEEFGIDENT DVNMSSLSSA TPLDHENANR APGKDLNGTL
1010 1020
EQQLSLDAFH SLPDETNKVA VDVEYCSS
Length:1,028
Mass (Da):115,262
Last modified:February 4, 2015 - v2
Checksum:i991B007C5F673D0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN294003 Genomic DNA. Translation: EEH33908.2.

Genome annotation databases

KEGGipbl:PAAG_04957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN294003 Genomic DNA. Translation: EEH33908.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGipbl:PAAG_04957.

Phylogenomic databases

KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-826 / Pb01Imported.

Entry informationi

Entry nameiC1H221_PARBA
AccessioniPrimary (citable) accession number: C1H221
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: February 4, 2015
Last modified: March 4, 2015
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.