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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

PAAG_04238

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (PAAG_01725), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (PAAG_06103), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (PAAG_04238)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:PAAG_04238Imported
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)Imported
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisParacoccidioides
Proteomesi
  • UP000002059 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PAAG_04238

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi502779.XP_002793966.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 486FAD_binding_2InterPro annotationAdd BLAST397
Domaini541 – 677Succ_DH_flav_CInterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
KOiK00234
OrthoDBiEOG092C1BHI

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

C1H0E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSQASMSMR RILAPTRHFP LAGKVDMHLS STSYFPKHND YTRKPSAGLD
60 70 80 90 100
NQRLWKRSFT STSGLYALQG VGQAKAVGLN HIQIIDHRYD ALVVGAGGAG
110 120 130 140 150
LMAAVGLAEC GLETACISKL FPTRSHTVAA QGGINAALGN MTEDDWRWHM
160 170 180 190 200
YDTVKGSDWL GDQDAIHYMC KEAPKTVLEL EGYGMPFSRT AEGKIYQRPI
210 220 230 240 250
GGQSLKYGSG GQAYRTACAA DRTGHAMLHA LYGQSLKHDC KFFIEFFALD
260 270 280 290 300
LMMVDGRCVG VTALDMETGT LHRLFSRNTI IATGGYGRAY FSCTSAHTST
310 320 330 340 350
GDGCAMASRA GLPLQDMEFV QFHPSGIYSA GVLITEGARG EGGYLLNSEG
360 370 380 390 400
ERFMERYAPT AKDLASRDVV ARSMNMEIRE GRGVGPDKDH IYLQLSHLPK
410 420 430 440 450
ELILERLPGI AETASIFAGI DITRQPIPVL PTVHYCMGGI PTNYKGQVLN
460 470 480 490 500
VDLATGKETP VPGLYAAGEA ACVSVHGANR LGANSLLDIA VFGRASAAHI
510 520 530 540 550
AENNEKGMLH SSVPRDIGMP SFEDMERLRT SDGRKLTAEL RLDMQKAMQS
560 570 580 590 600
DVAVFRAEDS LTSGVSKVQQ VEHSFRHDVC VKDKSLIWNS DLIETLEMRN
610 620 630 640 650
LLTCAAQTAK SALDRKESRG SHAREDFPDR DDVQFLKHSL SWQTEETEPV
660 670
KVGYRDVIFA TLDETDCPSV APKKRTY
Length:677
Mass (Da):74,099
Last modified:February 4, 2015 - v2
Checksum:iC23EE416621F0DCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN294001 Genomic DNA Translation: EEH33185.2
RefSeqiXP_015699444.1, XM_015845218.1

Genome annotation databases

EnsemblFungiiEEH33185; EEH33185; PAAG_04238
GeneIDi9097106
KEGGipbl:PAAG_04238

Similar proteinsi

Entry informationi

Entry nameiC1H0E4_PARBA
AccessioniPrimary (citable) accession number: C1H0E4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: February 4, 2015
Last modified: March 28, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health