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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

PAAG_04238

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (PAAG_01725), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (PAAG_06103), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (PAAG_04238)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:PAAG_04238Imported
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)Imported
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisParacoccidioides
Proteomesi
  • UP000002059 Componenti: Partially assembled WGS sequence

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi502779.XP_002793966.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 486FAD_binding_2InterPro annotationAdd BLAST397
Domaini541 – 677Succ_DH_flav_CInterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403. Eukaryota.
COG1053. LUCA.
KOiK00234.
OrthoDBiEOG092C1BHI.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1H0E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSQASMSMR RILAPTRHFP LAGKVDMHLS STSYFPKHND YTRKPSAGLD
60 70 80 90 100
NQRLWKRSFT STSGLYALQG VGQAKAVGLN HIQIIDHRYD ALVVGAGGAG
110 120 130 140 150
LMAAVGLAEC GLETACISKL FPTRSHTVAA QGGINAALGN MTEDDWRWHM
160 170 180 190 200
YDTVKGSDWL GDQDAIHYMC KEAPKTVLEL EGYGMPFSRT AEGKIYQRPI
210 220 230 240 250
GGQSLKYGSG GQAYRTACAA DRTGHAMLHA LYGQSLKHDC KFFIEFFALD
260 270 280 290 300
LMMVDGRCVG VTALDMETGT LHRLFSRNTI IATGGYGRAY FSCTSAHTST
310 320 330 340 350
GDGCAMASRA GLPLQDMEFV QFHPSGIYSA GVLITEGARG EGGYLLNSEG
360 370 380 390 400
ERFMERYAPT AKDLASRDVV ARSMNMEIRE GRGVGPDKDH IYLQLSHLPK
410 420 430 440 450
ELILERLPGI AETASIFAGI DITRQPIPVL PTVHYCMGGI PTNYKGQVLN
460 470 480 490 500
VDLATGKETP VPGLYAAGEA ACVSVHGANR LGANSLLDIA VFGRASAAHI
510 520 530 540 550
AENNEKGMLH SSVPRDIGMP SFEDMERLRT SDGRKLTAEL RLDMQKAMQS
560 570 580 590 600
DVAVFRAEDS LTSGVSKVQQ VEHSFRHDVC VKDKSLIWNS DLIETLEMRN
610 620 630 640 650
LLTCAAQTAK SALDRKESRG SHAREDFPDR DDVQFLKHSL SWQTEETEPV
660 670
KVGYRDVIFA TLDETDCPSV APKKRTY
Length:677
Mass (Da):74,099
Last modified:February 4, 2015 - v2
Checksum:iC23EE416621F0DCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN294001 Genomic DNA. Translation: EEH33185.2.
RefSeqiXP_015699444.1. XM_015845218.1.

Genome annotation databases

EnsemblFungiiEEH33185; EEH33185; PAAG_04238.
GeneIDi9097106.
KEGGipbl:PAAG_04238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN294001 Genomic DNA. Translation: EEH33185.2.
RefSeqiXP_015699444.1. XM_015845218.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi502779.XP_002793966.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEH33185; EEH33185; PAAG_04238.
GeneIDi9097106.
KEGGipbl:PAAG_04238.

Phylogenomic databases

eggNOGiKOG2403. Eukaryota.
COG1053. LUCA.
KOiK00234.
OrthoDBiEOG092C1BHI.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1H0E4_PARBA
AccessioniPrimary (citable) accession number: C1H0E4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: February 4, 2015
Last modified: September 7, 2016
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.