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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei272PROSITE-ProRule annotation1
Active sitei463PROSITE-ProRule annotation1
Active sitei525PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:PAAG_03512
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisParacoccidioides
Proteomesi
  • UP000002059 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:PAAG_03512

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000040746119 – 131By similarityAdd BLAST113
ChainiPRO_0000407462132 – 550Carboxypeptidase Y homolog AAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi185 ↔ 424By similarity
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi319 ↔ 333By similarity
Disulfide bondi343 ↔ 366By similarity
Disulfide bondi350 ↔ 359By similarity
Disulfide bondi388 ↔ 394By similarity
Glycosylationi493N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiC1GXD8

Interactioni

Protein-protein interaction databases

STRINGi502779.XP_002794967.1

Structurei

3D structure databases

SMRiC1GXD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
KOiK13289
OrthoDBiEOG092C1EU7

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C1GXD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLVLGLLV GSAIASGPLQ HVLHAPPEPE PEPEPEPQVV KDPFEELRDT
60 70 80 90 100
FDRLRNKAGD IWDDVMDNIP NIISNIRPPT IPPKKFTRLP DSEWTHIVRG
110 120 130 140 150
ADLEALWVDD ESGYKHRKVD GKLAQYDLRI RAVDPSNLGI DNVKQYSGYL
160 170 180 190 200
DDNLNDKHLF YWFFESRNDP DGDPVMLWLN GGPGCSSLTG MFFELGPSSI
210 220 230 240 250
TEDIKVKYNP YSWNSNSSII FLDQPVNVGF SYSSQPVSDT VAAAKDIYAL
260 270 280 290 300
LTLFFTQFPQ YSTQDFHIAG ESYAGHYIPV IASEIMHHKD RNINLQSVMI
310 320 330 340 350
GNGLTDPYTQ YPLYRPMACG EGGYPNVLDS ETCRSMDKAL PRCLSMIKSC
360 370 380 390 400
YDVESTFTCL PASIYCNNAL IGPYQSTGRN PYDVRIDCKG NGLCYPQLNY
410 420 430 440 450
ITDYLNQPYV MKSLGVEVDS YESCNMDINR NFLLHGDWMK PYHRLVPYLL
460 470 480 490 500
AQMPVLIYAG DADFICNWLG NKAWTEALEY PGHTKYAQSP MENLTMVNSE
510 520 530 540 550
GINEIFGEVK SHSNLTFMRI FKAGHMTPFD TPQASLEFAN SWLSGEWSEV
Length:550
Mass (Da):62,138
Last modified:May 26, 2009 - v1
Checksum:i8DE428F1D18102CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN293998 Genomic DNA Translation: EEH41226.1
RefSeqiXP_002794967.1, XM_002794921.2

Genome annotation databases

EnsemblFungiiEEH41226; EEH41226; PAAG_03512
GeneIDi9098180
KEGGipbl:PAAG_03512

Similar proteinsi

Entry informationi

Entry nameiCBPYA_PARBA
AccessioniPrimary (citable) accession number: C1GXD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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