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C1GXD8 (CBPYA_PARBA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:CPYA
ORF Names:PAAG_03512
OrganismParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) [Complete proteome]
Taxonomic identifier502779 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 131113 By similarity
PRO_0000407461
Chain132 – 550419Carboxypeptidase Y homolog A
PRO_0000407462

Sites

Active site2721 By similarity
Active site4631 By similarity
Active site5251 By similarity

Amino acid modifications

Glycosylation2161N-linked (GlcNAc...) Potential
Glycosylation4931N-linked (GlcNAc...) Potential
Glycosylation5141N-linked (GlcNAc...) Potential
Disulfide bond185 ↔ 424 By similarity
Disulfide bond319 ↔ 333 By similarity
Disulfide bond343 ↔ 366 By similarity
Disulfide bond350 ↔ 359 By similarity
Disulfide bond388 ↔ 394 By similarity

Sequences

Sequence LengthMass (Da)Tools
C1GXD8 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 8DE428F1D18102CB

FASTA55062,138
        10         20         30         40         50         60 
MKSLVLGLLV GSAIASGPLQ HVLHAPPEPE PEPEPEPQVV KDPFEELRDT FDRLRNKAGD 

        70         80         90        100        110        120 
IWDDVMDNIP NIISNIRPPT IPPKKFTRLP DSEWTHIVRG ADLEALWVDD ESGYKHRKVD 

       130        140        150        160        170        180 
GKLAQYDLRI RAVDPSNLGI DNVKQYSGYL DDNLNDKHLF YWFFESRNDP DGDPVMLWLN 

       190        200        210        220        230        240 
GGPGCSSLTG MFFELGPSSI TEDIKVKYNP YSWNSNSSII FLDQPVNVGF SYSSQPVSDT 

       250        260        270        280        290        300 
VAAAKDIYAL LTLFFTQFPQ YSTQDFHIAG ESYAGHYIPV IASEIMHHKD RNINLQSVMI 

       310        320        330        340        350        360 
GNGLTDPYTQ YPLYRPMACG EGGYPNVLDS ETCRSMDKAL PRCLSMIKSC YDVESTFTCL 

       370        380        390        400        410        420 
PASIYCNNAL IGPYQSTGRN PYDVRIDCKG NGLCYPQLNY ITDYLNQPYV MKSLGVEVDS 

       430        440        450        460        470        480 
YESCNMDINR NFLLHGDWMK PYHRLVPYLL AQMPVLIYAG DADFICNWLG NKAWTEALEY 

       490        500        510        520        530        540 
PGHTKYAQSP MENLTMVNSE GINEIFGEVK SHSNLTFMRI FKAGHMTPFD TPQASLEFAN 

       550 
SWLSGEWSEV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS572817 Genomic DNA. Translation: EEH41226.1.
RefSeqXP_002794967.1. XM_002794921.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9098180.
KEGGpbl:PAAG_03512.

Phylogenomic databases

KOK13289.
OrthoDBEOG7XDBR1.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_PARBA
AccessionPrimary (citable) accession number: C1GXD8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries