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C1GXD8

- CBPYA_PARBA

UniProt

C1GXD8 - CBPYA_PARBA

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Protein
Carboxypeptidase Y homolog A
Gene
CPYA, PAAG_03512
Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721 By similarity
Active sitei463 – 4631 By similarity
Active sitei525 – 5251 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:PAAG_03512
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000002059: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Propeptidei19 – 131113 By similarity
PRO_0000407461Add
BLAST
Chaini132 – 550419Carboxypeptidase Y homolog A
PRO_0000407462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi185 ↔ 424 By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi319 ↔ 333 By similarity
Disulfide bondi343 ↔ 366 By similarity
Disulfide bondi350 ↔ 359 By similarity
Disulfide bondi388 ↔ 394 By similarity
Glycosylationi493 – 4931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C1GXD8-1 [UniParc]FASTAAdd to Basket

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MKSLVLGLLV GSAIASGPLQ HVLHAPPEPE PEPEPEPQVV KDPFEELRDT    50
FDRLRNKAGD IWDDVMDNIP NIISNIRPPT IPPKKFTRLP DSEWTHIVRG 100
ADLEALWVDD ESGYKHRKVD GKLAQYDLRI RAVDPSNLGI DNVKQYSGYL 150
DDNLNDKHLF YWFFESRNDP DGDPVMLWLN GGPGCSSLTG MFFELGPSSI 200
TEDIKVKYNP YSWNSNSSII FLDQPVNVGF SYSSQPVSDT VAAAKDIYAL 250
LTLFFTQFPQ YSTQDFHIAG ESYAGHYIPV IASEIMHHKD RNINLQSVMI 300
GNGLTDPYTQ YPLYRPMACG EGGYPNVLDS ETCRSMDKAL PRCLSMIKSC 350
YDVESTFTCL PASIYCNNAL IGPYQSTGRN PYDVRIDCKG NGLCYPQLNY 400
ITDYLNQPYV MKSLGVEVDS YESCNMDINR NFLLHGDWMK PYHRLVPYLL 450
AQMPVLIYAG DADFICNWLG NKAWTEALEY PGHTKYAQSP MENLTMVNSE 500
GINEIFGEVK SHSNLTFMRI FKAGHMTPFD TPQASLEFAN SWLSGEWSEV 550
Length:550
Mass (Da):62,138
Last modified:May 26, 2009 - v1
Checksum:i8DE428F1D18102CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572817 Genomic DNA. Translation: EEH41226.1.
RefSeqiXP_002794967.1. XM_002794921.1.

Genome annotation databases

GeneIDi9098180.
KEGGipbl:PAAG_03512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572817 Genomic DNA. Translation: EEH41226.1 .
RefSeqi XP_002794967.1. XM_002794921.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9098180.
KEGGi pbl:PAAG_03512.

Phylogenomic databases

KOi K13289.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-826 / Pb01.

Entry informationi

Entry nameiCBPYA_PARBA
AccessioniPrimary (citable) accession number: C1GXD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi