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C1GXD8

- CBPYA_PARBA

UniProt

C1GXD8 - CBPYA_PARBA

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei272 – 2721PROSITE-ProRule annotation
    Active sitei463 – 4631PROSITE-ProRule annotation
    Active sitei525 – 5251PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:PAAG_03512
    OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
    Taxonomic identifieri502779 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
    ProteomesiUP000002059: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 131113By similarityPRO_0000407461Add
    BLAST
    Chaini132 – 550419Carboxypeptidase Y homolog APRO_0000407462Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi185 ↔ 424By similarity
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi319 ↔ 333By similarity
    Disulfide bondi343 ↔ 366By similarity
    Disulfide bondi350 ↔ 359By similarity
    Disulfide bondi388 ↔ 394By similarity
    Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK13289.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C1GXD8-1 [UniParc]FASTAAdd to Basket

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    MKSLVLGLLV GSAIASGPLQ HVLHAPPEPE PEPEPEPQVV KDPFEELRDT    50
    FDRLRNKAGD IWDDVMDNIP NIISNIRPPT IPPKKFTRLP DSEWTHIVRG 100
    ADLEALWVDD ESGYKHRKVD GKLAQYDLRI RAVDPSNLGI DNVKQYSGYL 150
    DDNLNDKHLF YWFFESRNDP DGDPVMLWLN GGPGCSSLTG MFFELGPSSI 200
    TEDIKVKYNP YSWNSNSSII FLDQPVNVGF SYSSQPVSDT VAAAKDIYAL 250
    LTLFFTQFPQ YSTQDFHIAG ESYAGHYIPV IASEIMHHKD RNINLQSVMI 300
    GNGLTDPYTQ YPLYRPMACG EGGYPNVLDS ETCRSMDKAL PRCLSMIKSC 350
    YDVESTFTCL PASIYCNNAL IGPYQSTGRN PYDVRIDCKG NGLCYPQLNY 400
    ITDYLNQPYV MKSLGVEVDS YESCNMDINR NFLLHGDWMK PYHRLVPYLL 450
    AQMPVLIYAG DADFICNWLG NKAWTEALEY PGHTKYAQSP MENLTMVNSE 500
    GINEIFGEVK SHSNLTFMRI FKAGHMTPFD TPQASLEFAN SWLSGEWSEV 550
    Length:550
    Mass (Da):62,138
    Last modified:May 26, 2009 - v1
    Checksum:i8DE428F1D18102CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS572817 Genomic DNA. Translation: EEH41226.1.
    RefSeqiXP_002794967.1. XM_002794921.1.

    Genome annotation databases

    GeneIDi9098180.
    KEGGipbl:PAAG_03512.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS572817 Genomic DNA. Translation: EEH41226.1 .
    RefSeqi XP_002794967.1. XM_002794921.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9098180.
    KEGGi pbl:PAAG_03512.

    Phylogenomic databases

    KOi K13289.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-826 / Pb01.

    Entry informationi

    Entry nameiCBPYA_PARBA
    AccessioniPrimary (citable) accession number: C1GXD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3