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C1GT79

- DAPB_PARBA

UniProt

C1GT79 - DAPB_PARBA

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei751 – 7511Charge relay systemPROSITE-ProRule annotation
    Active sitei828 – 8281Charge relay systemPROSITE-ProRule annotation
    Active sitei861 – 8611Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:PAAG_01724
    OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
    Taxonomic identifieri502779 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
    ProteomesiUP000002059: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 912912Probable dipeptidyl-aminopeptidase BPRO_0000412153Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi656 – 6561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi810 – 8101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi897 – 8971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliC1GT79.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9292CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini114 – 912799VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei93 – 11321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01282.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1GT79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAEKGESSD EERKPLTRDS MEYRDSSNSL HYSSSAASLS LAVIDRINGS    50
    THDTGPNEIG RGDRDYSDDG EYDLEEADYI PSGGKPVQKK VKIVLGFLLF 100
    LCLSGWSLSF VLFLFGGHES SKTSNVYDDN ISDTGSQGNK ITLDEVLDGT 150
    WSPAFHDISW IPGPNGEDGL LLERGASISN GYLRVEDIVS RKDPKSSKKP 200
    IVLMQKAYFN VSGEAVFPSR VWPSPDLKTV LVLSNEEKNW RHSFTGKYWL 250
    FDVESQTGQP LDPAAKDQRV QLASWSPRSD AVVFTRDNNM FLRKLSSNEV 300
    MKITTNGGVN LFYGVPDWVY EEEVYSGNSV TWWADDGEYI AFLRTNESSV 350
    PEYPVQYFVS LPNGEISKPG EESYPETRKI KYPKAGAPNP IVDLQFFDVG 400
    KDEVFSVDIK GDFADSNRLI TEVVWASNGK VIVRSTNRES DVLHVAVIDV 450
    LSRTGKIVRK EDINALDGGW VEPSQTARFI PADPDNGRLN DGYIDTVIYE 500
    GRDQLAYYTP VDNPNPIVLT KGHSEVVQAP SGVDLKRGLV YFVVAGNEPW 550
    ERHIYSVNFD GTSIQPVTNV SESSYYDVSF SNGAGYAFLK YAGPQVPWQK 600
    VISTPANEVT FEETIEENNR LSERLRQYTL ESKIYQYIDI DGFSLPVLER 650
    RPPNFNQTKK YPVLFYLYGG PGSQTVNKKF NVDFQSYVAA NLGYIVVTVD 700
    GRGTGFIGRK ARCVIRGNLG HFESRDQIQA AKIWAAKPYV DESRISIWGW 750
    SYGGFMALKT IEQDGGRTFK YGIAVAPVTD WRYYDSIYTE RYMHTPQRNP 800
    GGYDNAAISN TTALANNIRF LVMHGTADDN VHIQNSLTFI DKLDVNNVHN 850
    YDVHFFPDSD HSIYFHNAHK IVYSRLADWL VNAFNGEWLK TYNPAPNDSI 900
    FRRAAIWVGL SI 912
    Length:912
    Mass (Da):102,461
    Last modified:May 26, 2009 - v1
    Checksum:i018B5421BC256D62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS572813 Genomic DNA. Translation: EEH39262.1.
    RefSeqiXP_002796716.1. XM_002796670.1.

    Genome annotation databases

    GeneIDi9099681.
    KEGGipbl:PAAG_01724.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS572813 Genomic DNA. Translation: EEH39262.1 .
    RefSeqi XP_002796716.1. XM_002796670.1.

    3D structure databases

    ProteinModelPortali C1GT79.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9099681.
    KEGGi pbl:PAAG_01724.

    Phylogenomic databases

    KOi K01282.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-826 / Pb01.

    Entry informationi

    Entry nameiDAPB_PARBA
    AccessioniPrimary (citable) accession number: C1GT79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3