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C1GT79 (DAPB_PARBA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:PAAG_01724
OrganismParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) [Complete proteome]
Taxonomic identifier502779 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides

Protein attributes

Sequence length912 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 912912Probable dipeptidyl-aminopeptidase B
PRO_0000412153

Regions

Topological domain1 – 9292Cytoplasmic Potential
Transmembrane93 – 11321Helical; Signal-anchor for type II membrane protein; Potential
Topological domain114 – 912799Vacuolar Potential

Sites

Active site7511Charge relay system By similarity
Active site8281Charge relay system By similarity
Active site8611Charge relay system By similarity

Amino acid modifications

Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation3461N-linked (GlcNAc...) Potential
Glycosylation5691N-linked (GlcNAc...) Potential
Glycosylation6561N-linked (GlcNAc...) Potential
Glycosylation8101N-linked (GlcNAc...) Potential
Glycosylation8971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C1GT79 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 018B5421BC256D62

FASTA912102,461
        10         20         30         40         50         60 
MAAEKGESSD EERKPLTRDS MEYRDSSNSL HYSSSAASLS LAVIDRINGS THDTGPNEIG 

        70         80         90        100        110        120 
RGDRDYSDDG EYDLEEADYI PSGGKPVQKK VKIVLGFLLF LCLSGWSLSF VLFLFGGHES 

       130        140        150        160        170        180 
SKTSNVYDDN ISDTGSQGNK ITLDEVLDGT WSPAFHDISW IPGPNGEDGL LLERGASISN 

       190        200        210        220        230        240 
GYLRVEDIVS RKDPKSSKKP IVLMQKAYFN VSGEAVFPSR VWPSPDLKTV LVLSNEEKNW 

       250        260        270        280        290        300 
RHSFTGKYWL FDVESQTGQP LDPAAKDQRV QLASWSPRSD AVVFTRDNNM FLRKLSSNEV 

       310        320        330        340        350        360 
MKITTNGGVN LFYGVPDWVY EEEVYSGNSV TWWADDGEYI AFLRTNESSV PEYPVQYFVS 

       370        380        390        400        410        420 
LPNGEISKPG EESYPETRKI KYPKAGAPNP IVDLQFFDVG KDEVFSVDIK GDFADSNRLI 

       430        440        450        460        470        480 
TEVVWASNGK VIVRSTNRES DVLHVAVIDV LSRTGKIVRK EDINALDGGW VEPSQTARFI 

       490        500        510        520        530        540 
PADPDNGRLN DGYIDTVIYE GRDQLAYYTP VDNPNPIVLT KGHSEVVQAP SGVDLKRGLV 

       550        560        570        580        590        600 
YFVVAGNEPW ERHIYSVNFD GTSIQPVTNV SESSYYDVSF SNGAGYAFLK YAGPQVPWQK 

       610        620        630        640        650        660 
VISTPANEVT FEETIEENNR LSERLRQYTL ESKIYQYIDI DGFSLPVLER RPPNFNQTKK 

       670        680        690        700        710        720 
YPVLFYLYGG PGSQTVNKKF NVDFQSYVAA NLGYIVVTVD GRGTGFIGRK ARCVIRGNLG 

       730        740        750        760        770        780 
HFESRDQIQA AKIWAAKPYV DESRISIWGW SYGGFMALKT IEQDGGRTFK YGIAVAPVTD 

       790        800        810        820        830        840 
WRYYDSIYTE RYMHTPQRNP GGYDNAAISN TTALANNIRF LVMHGTADDN VHIQNSLTFI 

       850        860        870        880        890        900 
DKLDVNNVHN YDVHFFPDSD HSIYFHNAHK IVYSRLADWL VNAFNGEWLK TYNPAPNDSI 

       910 
FRRAAIWVGL SI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS572813 Genomic DNA. Translation: EEH39262.1.
RefSeqXP_002796716.1. XM_002796670.1.

3D structure databases

ProteinModelPortalC1GT79.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS09.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9099681.
KEGGpbl:PAAG_01724.

Phylogenomic databases

KOK01282.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_PARBA
AccessionPrimary (citable) accession number: C1GT79
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries