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C1GT79

- DAPB_PARBA

UniProt

C1GT79 - DAPB_PARBA

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Protein

Probable dipeptidyl-aminopeptidase B

Gene
DAPB, PAAG_01724
Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei751 – 7511Charge relay system By similarity
Active sitei828 – 8281Charge relay system By similarity
Active sitei861 – 8611Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:PAAG_01724
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000002059: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9292Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini114 – 912799Vacuolar Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 912912Probable dipeptidyl-aminopeptidase BPRO_0000412153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi346 – 3461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi656 – 6561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi810 – 8101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi897 – 8971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC1GT79.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1GT79-1 [UniParc]FASTAAdd to Basket

« Hide

MAAEKGESSD EERKPLTRDS MEYRDSSNSL HYSSSAASLS LAVIDRINGS    50
THDTGPNEIG RGDRDYSDDG EYDLEEADYI PSGGKPVQKK VKIVLGFLLF 100
LCLSGWSLSF VLFLFGGHES SKTSNVYDDN ISDTGSQGNK ITLDEVLDGT 150
WSPAFHDISW IPGPNGEDGL LLERGASISN GYLRVEDIVS RKDPKSSKKP 200
IVLMQKAYFN VSGEAVFPSR VWPSPDLKTV LVLSNEEKNW RHSFTGKYWL 250
FDVESQTGQP LDPAAKDQRV QLASWSPRSD AVVFTRDNNM FLRKLSSNEV 300
MKITTNGGVN LFYGVPDWVY EEEVYSGNSV TWWADDGEYI AFLRTNESSV 350
PEYPVQYFVS LPNGEISKPG EESYPETRKI KYPKAGAPNP IVDLQFFDVG 400
KDEVFSVDIK GDFADSNRLI TEVVWASNGK VIVRSTNRES DVLHVAVIDV 450
LSRTGKIVRK EDINALDGGW VEPSQTARFI PADPDNGRLN DGYIDTVIYE 500
GRDQLAYYTP VDNPNPIVLT KGHSEVVQAP SGVDLKRGLV YFVVAGNEPW 550
ERHIYSVNFD GTSIQPVTNV SESSYYDVSF SNGAGYAFLK YAGPQVPWQK 600
VISTPANEVT FEETIEENNR LSERLRQYTL ESKIYQYIDI DGFSLPVLER 650
RPPNFNQTKK YPVLFYLYGG PGSQTVNKKF NVDFQSYVAA NLGYIVVTVD 700
GRGTGFIGRK ARCVIRGNLG HFESRDQIQA AKIWAAKPYV DESRISIWGW 750
SYGGFMALKT IEQDGGRTFK YGIAVAPVTD WRYYDSIYTE RYMHTPQRNP 800
GGYDNAAISN TTALANNIRF LVMHGTADDN VHIQNSLTFI DKLDVNNVHN 850
YDVHFFPDSD HSIYFHNAHK IVYSRLADWL VNAFNGEWLK TYNPAPNDSI 900
FRRAAIWVGL SI 912
Length:912
Mass (Da):102,461
Last modified:May 26, 2009 - v1
Checksum:i018B5421BC256D62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572813 Genomic DNA. Translation: EEH39262.1.
RefSeqiXP_002796716.1. XM_002796670.1.

Genome annotation databases

GeneIDi9099681.
KEGGipbl:PAAG_01724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572813 Genomic DNA. Translation: EEH39262.1 .
RefSeqi XP_002796716.1. XM_002796670.1.

3D structure databases

ProteinModelPortali C1GT79.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9099681.
KEGGi pbl:PAAG_01724.

Phylogenomic databases

KOi K01282.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-826 / Pb01.

Entry informationi

Entry nameiDAPB_PARBA
AccessioniPrimary (citable) accession number: C1GT79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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