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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei185 – 1851By similarity
Active sitei387 – 3871By similarity
Active sitei449 – 4491By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:PAAG_00330
OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Taxonomic identifieri502779 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 520496LumenalSequence AnalysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST
Topological domaini542 – 64099CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 640616Pheromone-processing carboxypeptidase KEX1PRO_0000411931Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C1GP85-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGFSGSRANT ALGAWSKWLT LCLAMTQPFS VTAKSAADYY VHSLPGQPEG
60 70 80 90 100
PLLKMHAGHI EISPETSGNL FFWHFENRHI ADKPRTVVWL NGGPGCSSED
110 120 130 140 150
GALMEIGPYR LIDKETLNYT EGSWDEFANL LFVDQPVGTG FSYGSTEHYV
160 170 180 190 200
HELDEMASQF VTFLEKWFEI FPHYEPDDLY FAGESYAGQY IPYIARAILD
210 220 230 240 250
RNKKQDVLAN NRVWNLKGLL IGNGWISPQH QYPAYLPYVY QEGVVQGGTQ
260 270 280 290 300
EANLIEAKAA KCMKELNVED TTGTVHIPDC EDILQAILDY THKGKRCINM
310 320 330 340 350
YDIRLTDEYS ACGMNWPPDL KDVQPYLRRK DVVKALHINE EKQTGWTECA
360 370 380 390 400
GAVGSSFKAR KSKPAVELLP GLLEEGLPIL LFSGQKDLIC NHIGTEDMIK
410 420 430 440 450
NMKWSGGTGF ELSPGVWAPR QYWTFEGEPA GIYQQARNLT YVLFYNASHM
460 470 480 490 500
VPFDYPRRTR DMLDKFLGVD ITHIGGDPAD SRIDGEKGPT TSVGAHPNST
510 520 530 540 550
AAAEREKEKL NTAAWKAYYK SGEVALIIVS TAAVVWGIFL WRSRRKHQSS
560 570 580 590 600
GYRSIYPMLG LNSTGSLGRF SHKHSRGNGD IEAADFDETE LDGQPSQAFL
610 620 630 640
SRSSGDGETY AVGEESSDEE DGASDGQQLM FDQSRGEGRS
Length:640
Mass (Da):71,356
Last modified:May 26, 2009 - v1
Checksum:i71F91973FF0E0B4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN293992 Genomic DNA. Translation: EEH36007.1.
RefSeqiXP_002797791.1. XM_002797745.1.

Genome annotation databases

GeneIDi9100876.
KEGGipbl:PAAG_00330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN293992 Genomic DNA. Translation: EEH36007.1.
RefSeqiXP_002797791.1. XM_002797745.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9100876.
KEGGipbl:PAAG_00330.

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-826 / Pb01.

Entry informationi

Entry nameiKEX1_PARBA
AccessioniPrimary (citable) accession number: C1GP85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 26, 2009
Last modified: February 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.