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C1GP85 (KEX1_PARBA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:PAAG_00330
OrganismParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) [Complete proteome]
Taxonomic identifier502779 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 640616Pheromone-processing carboxypeptidase KEX1
PRO_0000411931

Regions

Topological domain25 – 520496Lumenal Potential
Transmembrane521 – 54121Helical; Potential
Topological domain542 – 64099Cytoplasmic Potential

Sites

Active site1851 By similarity
Active site3871 By similarity
Active site4491 By similarity

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation4381N-linked (GlcNAc...) Potential
Glycosylation4461N-linked (GlcNAc...) Potential
Glycosylation4981N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C1GP85 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 71F91973FF0E0B4B

FASTA64071,356
        10         20         30         40         50         60 
MGFSGSRANT ALGAWSKWLT LCLAMTQPFS VTAKSAADYY VHSLPGQPEG PLLKMHAGHI 

        70         80         90        100        110        120 
EISPETSGNL FFWHFENRHI ADKPRTVVWL NGGPGCSSED GALMEIGPYR LIDKETLNYT 

       130        140        150        160        170        180 
EGSWDEFANL LFVDQPVGTG FSYGSTEHYV HELDEMASQF VTFLEKWFEI FPHYEPDDLY 

       190        200        210        220        230        240 
FAGESYAGQY IPYIARAILD RNKKQDVLAN NRVWNLKGLL IGNGWISPQH QYPAYLPYVY 

       250        260        270        280        290        300 
QEGVVQGGTQ EANLIEAKAA KCMKELNVED TTGTVHIPDC EDILQAILDY THKGKRCINM 

       310        320        330        340        350        360 
YDIRLTDEYS ACGMNWPPDL KDVQPYLRRK DVVKALHINE EKQTGWTECA GAVGSSFKAR 

       370        380        390        400        410        420 
KSKPAVELLP GLLEEGLPIL LFSGQKDLIC NHIGTEDMIK NMKWSGGTGF ELSPGVWAPR 

       430        440        450        460        470        480 
QYWTFEGEPA GIYQQARNLT YVLFYNASHM VPFDYPRRTR DMLDKFLGVD ITHIGGDPAD 

       490        500        510        520        530        540 
SRIDGEKGPT TSVGAHPNST AAAEREKEKL NTAAWKAYYK SGEVALIIVS TAAVVWGIFL 

       550        560        570        580        590        600 
WRSRRKHQSS GYRSIYPMLG LNSTGSLGRF SHKHSRGNGD IEAADFDETE LDGQPSQAFL 

       610        620        630        640 
SRSSGDGETY AVGEESSDEE DGASDGQQLM FDQSRGEGRS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS572811 Genomic DNA. Translation: EEH36007.1.
RefSeqXP_002797791.1. XM_002797745.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9100876.
KEGGpbl:PAAG_00330.

Phylogenomic databases

KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKEX1_PARBA
AccessionPrimary (citable) accession number: C1GP85
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries