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C1GP85

- KEX1_PARBA

UniProt

C1GP85 - KEX1_PARBA

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei185 – 1851By similarity
    Active sitei387 – 3871By similarity
    Active sitei449 – 4491By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:PAAG_00330
    OrganismiParacoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
    Taxonomic identifieri502779 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
    ProteomesiUP000002059: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 640616Pheromone-processing carboxypeptidase KEX1PRO_0000411931Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 520496LumenalSequence AnalysisAdd
    BLAST
    Topological domaini542 – 64099CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C1GP85-1 [UniParc]FASTAAdd to Basket

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    MGFSGSRANT ALGAWSKWLT LCLAMTQPFS VTAKSAADYY VHSLPGQPEG    50
    PLLKMHAGHI EISPETSGNL FFWHFENRHI ADKPRTVVWL NGGPGCSSED 100
    GALMEIGPYR LIDKETLNYT EGSWDEFANL LFVDQPVGTG FSYGSTEHYV 150
    HELDEMASQF VTFLEKWFEI FPHYEPDDLY FAGESYAGQY IPYIARAILD 200
    RNKKQDVLAN NRVWNLKGLL IGNGWISPQH QYPAYLPYVY QEGVVQGGTQ 250
    EANLIEAKAA KCMKELNVED TTGTVHIPDC EDILQAILDY THKGKRCINM 300
    YDIRLTDEYS ACGMNWPPDL KDVQPYLRRK DVVKALHINE EKQTGWTECA 350
    GAVGSSFKAR KSKPAVELLP GLLEEGLPIL LFSGQKDLIC NHIGTEDMIK 400
    NMKWSGGTGF ELSPGVWAPR QYWTFEGEPA GIYQQARNLT YVLFYNASHM 450
    VPFDYPRRTR DMLDKFLGVD ITHIGGDPAD SRIDGEKGPT TSVGAHPNST 500
    AAAEREKEKL NTAAWKAYYK SGEVALIIVS TAAVVWGIFL WRSRRKHQSS 550
    GYRSIYPMLG LNSTGSLGRF SHKHSRGNGD IEAADFDETE LDGQPSQAFL 600
    SRSSGDGETY AVGEESSDEE DGASDGQQLM FDQSRGEGRS 640
    Length:640
    Mass (Da):71,356
    Last modified:May 26, 2009 - v1
    Checksum:i71F91973FF0E0B4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS572811 Genomic DNA. Translation: EEH36007.1.
    RefSeqiXP_002797791.1. XM_002797745.1.

    Genome annotation databases

    GeneIDi9100876.
    KEGGipbl:PAAG_00330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS572811 Genomic DNA. Translation: EEH36007.1 .
    RefSeqi XP_002797791.1. XM_002797745.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9100876.
    KEGGi pbl:PAAG_00330.

    Phylogenomic databases

    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-826 / Pb01.

    Entry informationi

    Entry nameiKEX1_PARBA
    AccessioniPrimary (citable) accession number: C1GP85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3