C1GHS9 (AMPP2_PARBD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PADG_06815
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

PADG_06815

Organism

Paracoccidioides brasiliensis (strain Pb18) [Complete proteome]

Taxonomic identifier

502780 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Paracoccidioides › Paracoccidioides brasiliensis

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 415	415	Probable Xaa-Pro aminopeptidase PADG_06815		PRO_0000411843
Sites
	Metal binding	194	1	Manganese 2 By similarity
	Metal binding	205	1	Manganese 1 By similarity
	Metal binding	205	1	Manganese 2 By similarity
	Metal binding	342	1	Manganese 1 By similarity
	Metal binding	380	1	Manganese 1 By similarity
	Metal binding	380	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1GHS9 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 537A6267EABCF775	FASTA	415	45,491
	10 20 30 40 50 60 MSGVNEADCD LTYDIQSDKL TLYVPNFDLG REIWMGPTLG PQDALKRYDI DEAKYQSFLQ 70 80 90 100 110 120 GDIKQWASCS GHGSTIYTLH DSQKPTGDFP NVFMDSETLK PAMDACRVIK DEHEIEQMRH 130 140 150 160 170 180 ANRVSTAAHI AVLQGICKMT NEAQIEGSFL NTCVSLGAHN QAYGIIAASG ANAATLHYSK 190 200 210 220 230 240 NNEPLKGRQF VCLDAGAEWN CHASDVTRTF PLTARWPGTE AEQIYALVQN MQESCILRIK 250 260 270 280 290 300 EGVRYLDLHH LAHDILIHGF LAIGIFKAGT ADEIKKSGAS SLFFPHGLGH HIGLEVHDVS 310 320 330 340 350 360 PDSIFAQDND GTTDSWLFSS TYLSPCTASS PTLKSGMVVT VEPGIYFSQI ALDNAKPAQL 370 380 390 400 410 KHIDMDVVKR YMAVGGVRIE DDILVTKDGF ENLTSAPKGQ AMLDYIQQGN GSCDI

References

[1]

"Annotation of Paracoccidioides brasiliensis Pb18." McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Ma L.-J.J., Henn M.R., Champion M., Cuomo C., Jaffe D.B., Young S.K., Gnerre S., Berlin A., Heiman D., Hepburn T., Sykes S., Yandava C., Alvarado L., Kodira C.D. , Guigo R., Borodovsky M., Goldman B., Klein B., Mendoza L., Nino-Vega G., San-Blas G., Sil A., de Almeida Soares C.M., Taylor J., Lander E.S., Nusbaum C., Galagan J.E., Birren B.W. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pb18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS572758 Genomic DNA. Translation: EEH50736.1.
3D structure databases
ProteinModelPortal	C1GHS9.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_PARBD

Accession

Primary (citable) accession number: C1GHS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	May 26, 2009
Last modified:	March 6, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program