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C1GG77

- CBPYA_PARBD

UniProt

C1GG77 - CBPYA_PARBD

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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Paracoccidioides brasiliensis (strain Pb18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721PROSITE-ProRule annotation
Active sitei463 – 4631PROSITE-ProRule annotation
Active sitei525 – 5251PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:PADG_06314
OrganismiParacoccidioides brasiliensis (strain Pb18)
Taxonomic identifieri502780 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000001628: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 131113By similarityPRO_0000407463Add
BLAST
Chaini132 – 550419Carboxypeptidase Y homolog APRO_0000407464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi185 ↔ 424By similarity
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi319 ↔ 333By similarity
Disulfide bondi343 ↔ 366By similarity
Disulfide bondi350 ↔ 359By similarity
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi388 ↔ 394By similarity
Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C1GG77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSLVLGLLV GSAIASGPLQ HVLHAPPDPE PKPEPEPQVV KDPFEELRDT
60 70 80 90 100
FDRLRNKAGD IWDDVMDNIP NIMSNMRPLT IPAKKFTRRP DSEWTHIVRG
110 120 130 140 150
ADLEALWVDD ESGYKHRKID GKLSQYDLRI KAVDPSDLGI DKVKQYSGYL
160 170 180 190 200
DDNANDKHLF FWFFESRNDP FGDPVVLWLN GGPGCSSLTG MFFELGPASI
210 220 230 240 250
DENITANYNP YSWNSNSSII FLDQPVNVGY SYSSQAVSDT VTAAKDVYAL
260 270 280 290 300
LTLFFTQFRQ YSAQDFHIAG ESYAGHYIPV FASEILHHNN TNINLQSVLI
310 320 330 340 350
GNGLTDPLSQ YPFYRPMACG DGGYPSVLDS QSCQSMDNAL PRCLSMIKSC
360 370 380 390 400
YDIESTFTCL PASIYCNNAL IGPYQKTGRN PYDVRTNCTG NDLCYPQLNY
410 420 430 440 450
ITEYLNKPHV MRSLGVEVDS YESCNMDINR NFLFHGDWMK PYHRLVPSLL
460 470 480 490 500
ARIPVLIYAG DADFICNWLG NKAWTEALEY PGHAKFAEAP MENLTMINSQ
510 520 530 540 550
GKNEVFGEVK SHSNLTFMRI FKAGHMTPFD SPQASLEFAN SWLSGEWSEV
Length:550
Mass (Da):61,910
Last modified:May 26, 2009 - v1
Checksum:iC9EBCE1DE53479AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS572757 Genomic DNA. Translation: EEH50235.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS572757 Genomic DNA. Translation: EEH50235.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pb18.

Entry informationi

Entry nameiCBPYA_PARBD
AccessioniPrimary (citable) accession number: C1GG77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3