C1GD57 (AMPP3_PARBD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase PEPP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	PEPP
ORF Names:	PADG_05193

Organism

Paracoccidioides brasiliensis (strain Pb18) [Complete proteome]

Taxonomic identifier

502780 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Paracoccidioides › Paracoccidioides brasiliensis

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Probable Xaa-Pro aminopeptidase PEPP		PRO_0000411880
Sites
	Metal binding	264	1	Manganese 2 By similarity
	Metal binding	275	1	Manganese 1 By similarity
	Metal binding	275	1	Manganese 2 By similarity
	Metal binding	398	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 1 By similarity
	Metal binding	438	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1GD57 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: D75188837ADCE09D	FASTA	468	51,900
	10 20 30 40 50 60 MAISVDQTPA GKYPAKVHAK RVAARIQELG HGDSGIIYLE GQKTHMIEDS DGEMPFRQRR 70 80 90 100 110 120 NFFYLSGCPL PDSYLTYDIK ADKLTIFIPP IDPASVIWSG LPLSVEEALE IYDVDAVLST 130 140 150 160 170 180 AEVNASLAHY CSAQGGKKVF AIADQVSPHI TFLPFQEIDF DVLKRAVEES RVVKDSYEIA 190 200 210 220 230 240 LLRRANEISS KAHVAVFKAA TSARNERELE AIFVGACMSS GCREQSYHPI FASGTNAATL 250 260 270 280 290 300 HYQKNDEDLV DSVTGQRRLN MLIDAGAEYR NYCADITRVV PLSGKFSPES REIYDIVLEM 310 320 330 340 350 360 QNSSLAMIKA GVMWEDVHST SHRVAIRGLL KLGILRSTEE ELFEKGISVA FFPHGLGHYL 370 380 390 400 410 420 GMDTHDTGGN PNYADKDPKF KYLRLRGPLA SGGVVTVEPG IYFCRFIIDP YLSSPDLGKY 430 440 450 460 INADVLERYW SVGGVRIEDN VVVTDSGYDN LTTAPKLPEE IERLATEK

References

[1]

"Annotation of Paracoccidioides brasiliensis Pb18." McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Ma L.-J.J., Henn M.R., Champion M., Cuomo C., Jaffe D.B., Young S.K., Gnerre S., Berlin A., Heiman D., Hepburn T., Sykes S., Yandava C., Alvarado L., Kodira C.D. , Guigo R., Borodovsky M., Goldman B., Klein B., Mendoza L., Nino-Vega G., San-Blas G., Sil A., de Almeida Soares C.M., Taylor J., Lander E.S., Nusbaum C., Galagan J.E., Birren B.W. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pb18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS572755 Genomic DNA. Translation: EEH49114.1.
3D structure databases
ProteinModelPortal	C1GD57.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_PARBD

Accession

Primary (citable) accession number: C1GD57

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	May 26, 2009
Last modified:	March 6, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program