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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Paracoccidioides brasiliensis (strain Pb18)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791By similarity
Active sitei381 – 3811By similarity
Active sitei443 – 4431By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:PADG_02348
OrganismiParacoccidioides brasiliensis (strain Pb18)
Taxonomic identifieri502780 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000001628 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 514487LumenalSequence AnalysisAdd
BLAST
Transmembranei515 – 53521HelicalSequence AnalysisAdd
BLAST
Topological domaini536 – 635100CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 635608Pheromone-processing carboxypeptidase KEX1PRO_0000411932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C1G2I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSGSRAWS KWLTICLAIT HPFSVTAKSA ADYYVHSLPG QPEGPLLKMH
60 70 80 90 100
AGHIEISPET SGNLFFWHFE NRHIADKPRT VVWLNGGPGC SSEDGALMEI
110 120 130 140 150
GPYRLIDKET LNYTEGSWDE FANLLFVDQP VGTGFSYGST EHYVHELDEM
160 170 180 190 200
ASQFVTFLEK WFEIFPHYEP DDLYFAGESY AGQYIPYIAR AVLDRNKKQD
210 220 230 240 250
VQANNRIWNL KGLLIGNGWI SPQHQYPAYL PYVYQEGVVQ AGTQEANLIE
260 270 280 290 300
AKAAKCMKEL NVEDTTGTVH IPDCEDILQA ILDYTHKGKR CINMYDIRLT
310 320 330 340 350
DDYSACGMNW PPDLRDIQPY LRRKDVVKAL HINEEKQTGW TECAGAVGSS
360 370 380 390 400
LKARNSKPAV ELLPGLLEEG LPILLFSGQK DLICNHVGTE DMIKNMKWSG
410 420 430 440 450
GTGFELSPGV WAPRQDWTFE GEPAGIYQQA RNLTYVLFYN ASHMVPFDYP
460 470 480 490 500
RRSRDMLDKF LGVDITHIGG DPADSRIDGE KGPTTSVGAH PNSTAAAERE
510 520 530 540 550
KEKLNTAAWK AYYKSGEVAL VIVAIAAFAW GIFIWRSRRK HQSSGYRSIY
560 570 580 590 600
PMLGLNSTGS LGQISHKHSR RNGDIEAADF DETELDDQPS QAFLSRSSRD
610 620 630
GDAYAVGEEG SDEEDGASDG QQPMFDQSRG EEGRS
Length:635
Mass (Da):70,987
Last modified:May 26, 2009 - v1
Checksum:iBFC88D5E0233F0A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN275958 Genomic DNA. Translation: EEH46198.1.
RefSeqiXP_010757777.1. XM_010759475.1.

Genome annotation databases

GeneIDi22581842.
KEGGipbn:PADG_02348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KN275958 Genomic DNA. Translation: EEH46198.1.
RefSeqiXP_010757777.1. XM_010759475.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22581842.
KEGGipbn:PADG_02348.

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pb18.

Entry informationi

Entry nameiKEX1_PARBD
AccessioniPrimary (citable) accession number: C1G2I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 26, 2009
Last modified: May 27, 2015
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.