Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C1G2I2

- KEX1_PARBD

UniProt

C1G2I2 - KEX1_PARBD

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Paracoccidioides brasiliensis (strain Pb18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei179 – 1791By similarity
    Active sitei381 – 3811By similarity
    Active sitei443 – 4431By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:PADG_02348
    OrganismiParacoccidioides brasiliensis (strain Pb18)
    Taxonomic identifieri502780 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
    ProteomesiUP000001628: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 635608Pheromone-processing carboxypeptidase KEX1PRO_0000411932Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 514487LumenalSequence AnalysisAdd
    BLAST
    Topological domaini536 – 635100CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei515 – 53521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C1G2I2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFSGSRAWS KWLTICLAIT HPFSVTAKSA ADYYVHSLPG QPEGPLLKMH    50
    AGHIEISPET SGNLFFWHFE NRHIADKPRT VVWLNGGPGC SSEDGALMEI 100
    GPYRLIDKET LNYTEGSWDE FANLLFVDQP VGTGFSYGST EHYVHELDEM 150
    ASQFVTFLEK WFEIFPHYEP DDLYFAGESY AGQYIPYIAR AVLDRNKKQD 200
    VQANNRIWNL KGLLIGNGWI SPQHQYPAYL PYVYQEGVVQ AGTQEANLIE 250
    AKAAKCMKEL NVEDTTGTVH IPDCEDILQA ILDYTHKGKR CINMYDIRLT 300
    DDYSACGMNW PPDLRDIQPY LRRKDVVKAL HINEEKQTGW TECAGAVGSS 350
    LKARNSKPAV ELLPGLLEEG LPILLFSGQK DLICNHVGTE DMIKNMKWSG 400
    GTGFELSPGV WAPRQDWTFE GEPAGIYQQA RNLTYVLFYN ASHMVPFDYP 450
    RRSRDMLDKF LGVDITHIGG DPADSRIDGE KGPTTSVGAH PNSTAAAERE 500
    KEKLNTAAWK AYYKSGEVAL VIVAIAAFAW GIFIWRSRRK HQSSGYRSIY 550
    PMLGLNSTGS LGQISHKHSR RNGDIEAADF DETELDDQPS QAFLSRSSRD 600
    GDAYAVGEEG SDEEDGASDG QQPMFDQSRG EEGRS 635
    Length:635
    Mass (Da):70,987
    Last modified:May 26, 2009 - v1
    Checksum:iBFC88D5E0233F0A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS572751 Genomic DNA. Translation: EEH46198.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS572751 Genomic DNA. Translation: EEH46198.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pb18.

    Entry informationi

    Entry nameiKEX1_PARBD
    AccessioniPrimary (citable) accession number: C1G2I2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3