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C1G2I2 (KEX1_PARBD) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:PADG_02348
OrganismParacoccidioides brasiliensis (strain Pb18) [Complete proteome]
Taxonomic identifier502780 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 635608Pheromone-processing carboxypeptidase KEX1
PRO_0000411932

Regions

Topological domain28 – 514487Lumenal Potential
Transmembrane515 – 53521Helical; Potential
Topological domain536 – 635100Cytoplasmic Potential

Sites

Active site1791 By similarity
Active site3811 By similarity
Active site4431 By similarity

Amino acid modifications

Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation4321N-linked (GlcNAc...) Potential
Glycosylation4401N-linked (GlcNAc...) Potential
Glycosylation4921N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C1G2I2 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: BFC88D5E0233F0A6

FASTA63570,987
        10         20         30         40         50         60 
MGFSGSRAWS KWLTICLAIT HPFSVTAKSA ADYYVHSLPG QPEGPLLKMH AGHIEISPET 

        70         80         90        100        110        120 
SGNLFFWHFE NRHIADKPRT VVWLNGGPGC SSEDGALMEI GPYRLIDKET LNYTEGSWDE 

       130        140        150        160        170        180 
FANLLFVDQP VGTGFSYGST EHYVHELDEM ASQFVTFLEK WFEIFPHYEP DDLYFAGESY 

       190        200        210        220        230        240 
AGQYIPYIAR AVLDRNKKQD VQANNRIWNL KGLLIGNGWI SPQHQYPAYL PYVYQEGVVQ 

       250        260        270        280        290        300 
AGTQEANLIE AKAAKCMKEL NVEDTTGTVH IPDCEDILQA ILDYTHKGKR CINMYDIRLT 

       310        320        330        340        350        360 
DDYSACGMNW PPDLRDIQPY LRRKDVVKAL HINEEKQTGW TECAGAVGSS LKARNSKPAV 

       370        380        390        400        410        420 
ELLPGLLEEG LPILLFSGQK DLICNHVGTE DMIKNMKWSG GTGFELSPGV WAPRQDWTFE 

       430        440        450        460        470        480 
GEPAGIYQQA RNLTYVLFYN ASHMVPFDYP RRSRDMLDKF LGVDITHIGG DPADSRIDGE 

       490        500        510        520        530        540 
KGPTTSVGAH PNSTAAAERE KEKLNTAAWK AYYKSGEVAL VIVAIAAFAW GIFIWRSRRK 

       550        560        570        580        590        600 
HQSSGYRSIY PMLGLNSTGS LGQISHKHSR RNGDIEAADF DETELDDQPS QAFLSRSSRD 

       610        620        630 
GDAYAVGEEG SDEEDGASDG QQPMFDQSRG EEGRS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS572751 Genomic DNA. Translation: EEH46198.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKEX1_PARBD
AccessionPrimary (citable) accession number: C1G2I2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries