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C1FZL3

- DAPB_PARBD

UniProt

C1FZL3 - DAPB_PARBD

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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Paracoccidioides brasiliensis (strain Pb18)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei751 – 7511Charge relay systemPROSITE-ProRule annotation
Active sitei828 – 8281Charge relay systemPROSITE-ProRule annotation
Active sitei861 – 8611Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:PADG_00053
OrganismiParacoccidioides brasiliensis (strain Pb18)
Taxonomic identifieri502780 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000001628: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 912912Probable dipeptidyl-aminopeptidase BPRO_0000412154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi656 – 6561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi810 – 8101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi897 – 8971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC1FZL3.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9292CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini114 – 912799VacuolarSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei93 – 11321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1FZL3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAEKGGSSD EERKPLTRGS MEYRDSSNSL HYSSSAASLS LAVIDRINGS
60 70 80 90 100
THDTGPDEIG RGDRDYSDDG EYDLEEADYI PSGGKPVQKK VKIVLGFLLF
110 120 130 140 150
LCLSGWSLAF VLFLFGGHES SKTSIVYEDN ISDTGSQGIK ITLDEVFDGT
160 170 180 190 200
WSPNSRDISW IPGPNGEDGL LLEKGASISN GYLRVEDIVS RKDPKSSKKP
210 220 230 240 250
IVLMQKAYFN VSGEAVFPSR VWPSPDLKTV LVLSNEEKNW RHSFTGKYWL
260 270 280 290 300
FDVESQTGQP LDPAAKDQRV QLASWSPRSD AVVFTRDNNM FLRKLSSNEV
310 320 330 340 350
IKITTNGGVN LFYGVPDWVY EEEVFSGNSV TWWADDGEYI AFLRTNESSV
360 370 380 390 400
PEYPVQYFVS RPNGEIPKPG GESYPETRKI KYPKAGAPNP IVDLQFFDVG
410 420 430 440 450
KDEVFSVDIK GDFADSNRLI IEVVWASNGK VIVRSTNRES DVLHVAVIDV
460 470 480 490 500
LSRTGKIVRK EDINALDGGW VEPSQTTRFI PADPDNGRLN DGYIDTVIYE
510 520 530 540 550
GRDQLAYYTP IDNPKPIVLT NGHSEVVQAP SGVDLKRGLV YFVVAGNEPW
560 570 580 590 600
ERHIYSVNFD GTSLQPVTNV SESSYYDVSF SNGAGYAFLK YAGPQVPWQK
610 620 630 640 650
VISTPANEVT FEETIEENNH LSERLRQYTL ESKIYQYIDI DGFSLPVLER
660 670 680 690 700
RPPNFNQTKK YPVLFYLYGG PGSQTVKKKF NVDFQSYVAA NLGYIVVTVD
710 720 730 740 750
GRGTGFIGRK ARCIIRGNLG HFESLDQIQA AKIWAAKPYV DESRISIWGW
760 770 780 790 800
SYGGFMALKT IEQDGGRTFK YGIAVAPVTD WRYYDSIYTE RYMHTPQRNP
810 820 830 840 850
GGYDNAAISN TTALANNIRF LVMHGTADDN VHIQNSLTFI DKLDVNNVHN
860 870 880 890 900
YDVHFFPDSD HSIYFHNAHK IVYSRLADWL VNAFNGEWLK TYDPTPNDSI
910
LRRAATWVGM SI
Length:912
Mass (Da):102,308
Last modified:May 26, 2009 - v1
Checksum:i7BF8C0744459EAA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572750 Genomic DNA. Translation: EEH43764.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572750 Genomic DNA. Translation: EEH43764.1 .

3D structure databases

ProteinModelPortali C1FZL3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pb18.

Entry informationi

Entry nameiDAPB_PARBD
AccessioniPrimary (citable) accession number: C1FZL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3