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C1FZL3

- DAPB_PARBD

UniProt

C1FZL3 - DAPB_PARBD

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
DAPB, PADG_00053
Organism
Paracoccidioides brasiliensis (strain Pb18)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei751 – 7511Charge relay system By similarity
Active sitei828 – 8281Charge relay system By similarity
Active sitei861 – 8611Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:PADG_00053
OrganismiParacoccidioides brasiliensis (strain Pb18)
Taxonomic identifieri502780 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesParacoccidioides
ProteomesiUP000001628: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9292Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini114 – 912799Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 912912Probable dipeptidyl-aminopeptidase B
PRO_0000412154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi346 – 3461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi656 – 6561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi810 – 8101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi897 – 8971N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC1FZL3.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1FZL3-1 [UniParc]FASTAAdd to Basket

« Hide

MAAEKGGSSD EERKPLTRGS MEYRDSSNSL HYSSSAASLS LAVIDRINGS    50
THDTGPDEIG RGDRDYSDDG EYDLEEADYI PSGGKPVQKK VKIVLGFLLF 100
LCLSGWSLAF VLFLFGGHES SKTSIVYEDN ISDTGSQGIK ITLDEVFDGT 150
WSPNSRDISW IPGPNGEDGL LLEKGASISN GYLRVEDIVS RKDPKSSKKP 200
IVLMQKAYFN VSGEAVFPSR VWPSPDLKTV LVLSNEEKNW RHSFTGKYWL 250
FDVESQTGQP LDPAAKDQRV QLASWSPRSD AVVFTRDNNM FLRKLSSNEV 300
IKITTNGGVN LFYGVPDWVY EEEVFSGNSV TWWADDGEYI AFLRTNESSV 350
PEYPVQYFVS RPNGEIPKPG GESYPETRKI KYPKAGAPNP IVDLQFFDVG 400
KDEVFSVDIK GDFADSNRLI IEVVWASNGK VIVRSTNRES DVLHVAVIDV 450
LSRTGKIVRK EDINALDGGW VEPSQTTRFI PADPDNGRLN DGYIDTVIYE 500
GRDQLAYYTP IDNPKPIVLT NGHSEVVQAP SGVDLKRGLV YFVVAGNEPW 550
ERHIYSVNFD GTSLQPVTNV SESSYYDVSF SNGAGYAFLK YAGPQVPWQK 600
VISTPANEVT FEETIEENNH LSERLRQYTL ESKIYQYIDI DGFSLPVLER 650
RPPNFNQTKK YPVLFYLYGG PGSQTVKKKF NVDFQSYVAA NLGYIVVTVD 700
GRGTGFIGRK ARCIIRGNLG HFESLDQIQA AKIWAAKPYV DESRISIWGW 750
SYGGFMALKT IEQDGGRTFK YGIAVAPVTD WRYYDSIYTE RYMHTPQRNP 800
GGYDNAAISN TTALANNIRF LVMHGTADDN VHIQNSLTFI DKLDVNNVHN 850
YDVHFFPDSD HSIYFHNAHK IVYSRLADWL VNAFNGEWLK TYDPTPNDSI 900
LRRAATWVGM SI 912
Length:912
Mass (Da):102,308
Last modified:May 26, 2009 - v1
Checksum:i7BF8C0744459EAA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572750 Genomic DNA. Translation: EEH43764.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS572750 Genomic DNA. Translation: EEH43764.1 .

3D structure databases

ProteinModelPortali C1FZL3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pb18.

Entry informationi

Entry nameiDAPB_PARBD
AccessioniPrimary (citable) accession number: C1FZL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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