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C1FU68

- ASSY_CLOBJ

UniProt

C1FU68 - ASSY_CLOBJ

Protein

Argininosuccinate synthase

Gene

argG

Organism
Clostridium botulinum (strain Kyoto / Type A2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861CitrullineUniRule annotation
    Binding sitei91 – 911CitrullineUniRule annotation
    Binding sitei116 – 1161ATP; via amide nitrogenUniRule annotation
    Binding sitei118 – 1181AspartateUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei122 – 1221CitrullineUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei126 – 1261CitrullineUniRule annotation
    Binding sitei175 – 1751CitrullineUniRule annotation
    Binding sitei184 – 1841CitrullineUniRule annotation
    Binding sitei260 – 2601CitrullineUniRule annotation
    Binding sitei272 – 2721CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 169ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBOT536232:GCO3-2946-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:CLM_3035
    OrganismiClostridium botulinum (strain Kyoto / Type A2)
    Taxonomic identifieri536232 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001374: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Argininosuccinate synthasePRO_1000191889Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi536232.CLM_3035.

    Structurei

    3D structure databases

    ProteinModelPortaliC1FU68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiPECEYIR.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1FU68-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEKVVLAYS GGLDTSIIIP WLKENYDLDV IAVCVNVGQG DDMDYVKTKA    50
    IKSGASKIYV EDVKEEFVVD YLYKAIKSEA LYEQDYMLGT SFARPLMAKK 100
    LVEIAHKEQA KYICHGCTGK GNDQVRFEVG VKAQDPIIKI IAPWRIWDIK 150
    SREDAIDYAK KVGVEVPVTK KKIYSVDKNL WHVSHEGGDL EDLKNEHKED 200
    MYFMVTPPEK AKNEPTYLEI YFEKGAPVKI NGEVLNPVDI IDKLNTIGGE 250
    NGIGIADIIE NRLVGMKSRG IYETPAGTLL YAAHKKLESV TLDKYTYQYK 300
    KIVSAQYGEL VYNGLWFTSL REAIDAFVDK TQENVTGTVQ LKLYKGNIKP 350
    CSVDTEYALY DEGISSFGES ELYSHKDAEG FINLFGLPSK IKALKNF 397
    Length:397
    Mass (Da):44,742
    Last modified:May 26, 2009 - v1
    Checksum:i7D3A75EB7FBDC968
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001581 Genomic DNA. Translation: ACO86433.1.
    RefSeqiWP_012705317.1. NC_012563.1.
    YP_002805173.1. NC_012563.1.

    Genome annotation databases

    EnsemblBacteriaiACO86433; ACO86433; CLM_3035.
    GeneIDi7764589.
    KEGGicby:CLM_3035.
    PATRICi19382513. VBICloBot91161_2882.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001581 Genomic DNA. Translation: ACO86433.1 .
    RefSeqi WP_012705317.1. NC_012563.1.
    YP_002805173.1. NC_012563.1.

    3D structure databases

    ProteinModelPortali C1FU68.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 536232.CLM_3035.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO86433 ; ACO86433 ; CLM_3035 .
    GeneIDi 7764589.
    KEGGi cby:CLM_3035.
    PATRICi 19382513. VBICloBot91161_2882.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi PECEYIR.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci CBOT536232:GCO3-2946-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Clostridium botulinum A2 Kyoto."
      Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C., Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Kyoto / Type A2.

    Entry informationi

    Entry nameiASSY_CLOBJ
    AccessioniPrimary (citable) accession number: C1FU68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3