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C1FSC2 (THIM1_CLOBJ) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase 1

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 1
Short name=TH kinase 1
Short name=Thz kinase 1
Gene names
Name:thiM1
Ordered Locus Names:CLM_0532
OrganismClostridium botulinum (strain Kyoto / Type A2) [Complete proteome] [HAMAP]
Taxonomic identifier536232 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Hydroxyethylthiazole kinase 1 HAMAP-Rule MF_00228
PRO_1000198113

Sites

Binding site421Substrate; via amide nitrogen By similarity
Binding site1181ATP By similarity
Binding site1641ATP By similarity
Binding site1911Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
C1FSC2 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 7F36BB42D5083F73

FASTA26328,453
        10         20         30         40         50         60 
MENKNVIQKM REKTPLIHCI TNYVTINDCA NILLSFGASP AMCEAYDEVY DFVSISSALY 

        70         80         90        100        110        120 
INLGTLTKEQ ETAAVLASIS AKNHNVPVVI DPVGCPAIKR KVEVINRIAE VGRIDIIKGN 

       130        140        150        160        170        180 
IGEIKFLAGM DSETRGVDSL DNGENALDAC TQLAKKYNCI VAATGQKDFV SDGKRGSVIK 

       190        200        210        220        230        240 
NGTEMLTKVT GAGCMLGALC AATCANFEDK LVSTTAAILS MNIAGEKAYE KAQLPGSFRI 

       250        260 
ALIDNIYMIS DKEIWERGNV EWK 

« Hide

References

[1]"Genome sequence of Clostridium botulinum A2 Kyoto."
Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C., Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Kyoto / Type A2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001581 Genomic DNA. Translation: ACO87276.1.
RefSeqYP_002802777.1. NC_012563.1.

3D structure databases

ProteinModelPortalC1FSC2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING536232.CLM_0532.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO87276; ACO87276; CLM_0532.
GeneID7766374.
KEGGcby:CLM_0532.
PATRIC19377679. VBICloBot91161_0466.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMANACTQLA.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycCBOT536232:GCO3-510-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM1_CLOBJ
AccessionPrimary (citable) accession number: C1FSC2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways