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C1FS47

- C1FS47_CLOBJ

UniProt

C1FS47 - C1FS47_CLOBJ

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Protein

Ribosomal protein S12 methylthiotransferase RimO

Gene

rimO

Organism
Clostridium botulinum (strain Kyoto / Type A2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi48 – 481Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi82 – 821Iron-sulfur (4Fe-4S)UniRule annotation
Metal bindingi156 – 1561Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi160 – 1601Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi163 – 1631Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP
  3. transferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid Source: UniProtKB-HAMAP
  2. RNA modification Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Ligandi

4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCBOT536232:GCO3-2619-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S12 methylthiotransferase RimOUniRule annotation (EC:2.-.-.-UniRule annotation)
Short name:
S12 MTTaseUniRule annotation
Short name:
S12 methylthiotransferaseUniRule annotation
Alternative name(s):
Ribosome maturation factor RimOUniRule annotation
Gene namesi
Name:rimOUniRule annotation
Ordered Locus Names:CLM_2699Imported
OrganismiClostridium botulinum (strain Kyoto / Type A2)Imported
Taxonomic identifieri536232 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001374: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi536232.CLM_2699.

Structurei

3D structure databases

ProteinModelPortaliC1FS47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 119116MTTase N-terminalUniRule annotationAdd
BLAST
Domaini375 – 44167TRAMUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the methylthiotransferase family. RimO subfamily.UniRule annotation
Contains 1 MTTase N-terminal domain.UniRule annotation
Contains 1 TRAM domain.UniRule annotation
Contains MTTase N-terminal domain.SAAS annotation
Contains TRAM domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0621.
HOGENOMiHOG000224766.
KOiK14441.
OMAiNTCTFID.
OrthoDBiEOG6P5ZD8.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.80.30.20. 1 hit.
HAMAPiMF_01865. MTTase_RimO.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR012340. NA-bd_OB-fold.
IPR005840. Ribosomal_S12_MeSTrfase_RimO.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view]
PANTHERiPTHR11918. PTHR11918. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
TIGR01125. TIGR01125. 1 hit.
PROSITEiPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1FS47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKIKVALVS LGCDKNRIDS ELMLYKLNEE AELVKNPKEA QVIIVNTCGF
60 70 80 90 100
IETAKEESIN TILQMASYKK THNCKVLVVT GCLTQRYKGE LKELIPEMDI
110 120 130 140 150
MLGVNDYDKL LESIKVFLKS GEKSFYHKYS DTKINEGNRI LTTPTYTAYV
160 170 180 190 200
RIAEGCNNFC TYCAIPRIRG KYRSRKKENI LKEVENLAKQ GVKEIILIAQ
210 220 230 240 250
DTTMYGIDIY GKKVLHELLR DISKVEGVKW IRLLYCYPEE ITKELIEEIK
260 270 280 290 300
NNDKVCKYLD LPIQQISNSV LKRMGRKTTK ETIINIIKKL RKEIEGITLR
310 320 330 340 350
TSLIVGFPGE TEGEFSELKE FVSDVKLDKL GVFKYSKEEG TSAALMKEQI
360 370 380 390 400
DEEIKEKREE EIMILQQSIS KDINKEKIGK IYEVIVEGTK EDMYYGRNYE
410 420 430 440
MSPEIDGEIY FEKDENVKIG DIIKVKVTHS LEYDLIGVVY NELSK
Length:445
Mass (Da):51,361
Last modified:May 26, 2009 - v1
Checksum:iF3A5018A43591715
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001581 Genomic DNA. Translation: ACO86397.1.
RefSeqiYP_002804850.1. NC_012563.1.

Genome annotation databases

EnsemblBacteriaiACO86397; ACO86397; CLM_2699.
GeneIDi7765153.
KEGGicby:CLM_2699.
PATRICi19381855. VBICloBot91161_2553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001581 Genomic DNA. Translation: ACO86397.1 .
RefSeqi YP_002804850.1. NC_012563.1.

3D structure databases

ProteinModelPortali C1FS47.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 536232.CLM_2699.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO86397 ; ACO86397 ; CLM_2699 .
GeneIDi 7765153.
KEGGi cby:CLM_2699.
PATRICi 19381855. VBICloBot91161_2553.

Phylogenomic databases

eggNOGi COG0621.
HOGENOMi HOG000224766.
KOi K14441.
OMAi NTCTFID.
OrthoDBi EOG6P5ZD8.

Enzyme and pathway databases

BioCyci CBOT536232:GCO3-2619-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.80.30.20. 1 hit.
HAMAPi MF_01865. MTTase_RimO.
InterProi IPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR012340. NA-bd_OB-fold.
IPR005840. Ribosomal_S12_MeSTrfase_RimO.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view ]
PANTHERi PTHR11918. PTHR11918. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
TIGR01125. TIGR01125. 1 hit.
PROSITEi PS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Clostridium botulinum A2 Kyoto."
    Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C., Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Kyoto / Type A2Imported.

Entry informationi

Entry nameiC1FS47_CLOBJ
AccessioniPrimary (citable) accession number: C1FS47
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3