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C1FS47

- C1FS47_CLOBJ

UniProt

C1FS47 - C1FS47_CLOBJ

Protein

Ribosomal protein S12 methylthiotransferase RimO

Gene

rimO

Organism
Clostridium botulinum (strain Kyoto / Type A2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi13 – 131Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi48 – 481Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi82 – 821Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi156 – 1561Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi160 – 1601Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi163 – 1631Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP
    3. transferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid Source: UniProtKB-HAMAP
    2. RNA modification Source: InterPro

    Keywords - Molecular functioni

    TransferaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCBOT536232:GCO3-2619-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal protein S12 methylthiotransferase RimOUniRule annotation (EC:2.-.-.-UniRule annotation)
    Short name:
    S12 MTTaseUniRule annotation
    Short name:
    S12 methylthiotransferaseUniRule annotation
    Alternative name(s):
    Ribosome maturation factor RimOUniRule annotation
    Gene namesi
    Name:rimOUniRule annotation
    Ordered Locus Names:CLM_2699Imported
    OrganismiClostridium botulinum (strain Kyoto / Type A2)Imported
    Taxonomic identifieri536232 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001374: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi536232.CLM_2699.

    Structurei

    3D structure databases

    ProteinModelPortaliC1FS47.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 119116MTTase N-terminalUniRule annotationAdd
    BLAST
    Domaini375 – 44167TRAMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methylthiotransferase family. RimO subfamily.UniRule annotation
    Contains 1 MTTase N-terminal domain.UniRule annotation
    Contains 1 TRAM domain.UniRule annotation
    Contains MTTase N-terminal domain.SAAS annotation
    Contains TRAM domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0621.
    HOGENOMiHOG000224766.
    KOiK14441.
    OMAiNTCTFID.
    OrthoDBiEOG6P5ZD8.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.80.30.20. 1 hit.
    HAMAPiMF_01865. MTTase_RimO.
    InterProiIPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR012340. NA-bd_OB-fold.
    IPR005840. Ribosomal_S12_MeSTrfase_RimO.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view]
    PANTHERiPTHR11918. PTHR11918. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
    TIGR01125. TIGR01125. 1 hit.
    PROSITEiPS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C1FS47-1 [UniParc]FASTAAdd to Basket

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    MEKIKVALVS LGCDKNRIDS ELMLYKLNEE AELVKNPKEA QVIIVNTCGF    50
    IETAKEESIN TILQMASYKK THNCKVLVVT GCLTQRYKGE LKELIPEMDI 100
    MLGVNDYDKL LESIKVFLKS GEKSFYHKYS DTKINEGNRI LTTPTYTAYV 150
    RIAEGCNNFC TYCAIPRIRG KYRSRKKENI LKEVENLAKQ GVKEIILIAQ 200
    DTTMYGIDIY GKKVLHELLR DISKVEGVKW IRLLYCYPEE ITKELIEEIK 250
    NNDKVCKYLD LPIQQISNSV LKRMGRKTTK ETIINIIKKL RKEIEGITLR 300
    TSLIVGFPGE TEGEFSELKE FVSDVKLDKL GVFKYSKEEG TSAALMKEQI 350
    DEEIKEKREE EIMILQQSIS KDINKEKIGK IYEVIVEGTK EDMYYGRNYE 400
    MSPEIDGEIY FEKDENVKIG DIIKVKVTHS LEYDLIGVVY NELSK 445
    Length:445
    Mass (Da):51,361
    Last modified:May 26, 2009 - v1
    Checksum:iF3A5018A43591715
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001581 Genomic DNA. Translation: ACO86397.1.
    RefSeqiYP_002804850.1. NC_012563.1.

    Genome annotation databases

    EnsemblBacteriaiACO86397; ACO86397; CLM_2699.
    GeneIDi7765153.
    KEGGicby:CLM_2699.
    PATRICi19381855. VBICloBot91161_2553.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001581 Genomic DNA. Translation: ACO86397.1 .
    RefSeqi YP_002804850.1. NC_012563.1.

    3D structure databases

    ProteinModelPortali C1FS47.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 536232.CLM_2699.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO86397 ; ACO86397 ; CLM_2699 .
    GeneIDi 7765153.
    KEGGi cby:CLM_2699.
    PATRICi 19381855. VBICloBot91161_2553.

    Phylogenomic databases

    eggNOGi COG0621.
    HOGENOMi HOG000224766.
    KOi K14441.
    OMAi NTCTFID.
    OrthoDBi EOG6P5ZD8.

    Enzyme and pathway databases

    BioCyci CBOT536232:GCO3-2619-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.80.30.20. 1 hit.
    HAMAPi MF_01865. MTTase_RimO.
    InterProi IPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR012340. NA-bd_OB-fold.
    IPR005840. Ribosomal_S12_MeSTrfase_RimO.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view ]
    PANTHERi PTHR11918. PTHR11918. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
    TIGR01125. TIGR01125. 1 hit.
    PROSITEi PS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Clostridium botulinum A2 Kyoto."
      Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C., Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Kyoto / Type A2Imported.

    Entry informationi

    Entry nameiC1FS47_CLOBJ
    AccessioniPrimary (citable) accession number: C1FS47
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3