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C1FR28

- THIM2_CLOBJ

UniProt

C1FR28 - THIM2_CLOBJ

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Protein

Hydroxyethylthiazole kinase 2

Gene
thiM2, CLM_2460
Organism
Clostridium botulinum (strain Kyoto / Type A2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate; via amide nitrogen By similarity
Binding sitei115 – 1151ATP By similarity
Binding sitei168 – 1681ATP By similarity
Binding sitei195 – 1951Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT536232:GCO3-2383-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase 2 (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 2
Short name:
TH kinase 2
Short name:
Thz kinase 2
Gene namesi
Name:thiM2
Ordered Locus Names:CLM_2460
OrganismiClostridium botulinum (strain Kyoto / Type A2)
Taxonomic identifieri536232 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001374: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Hydroxyethylthiazole kinase 2UniRule annotationPRO_0000383844Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi536232.CLM_2460.

Structurei

3D structure databases

ProteinModelPortaliC1FR28.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiAKPIMAE.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

C1FR28-1 [UniParc]FASTAAdd to Basket

« Hide

MQIRQSVKFK KPLIHYITNP ISINDCANMI LAVGAKPIMA EHPLEVSEIT    50
SISESLGINL GNITDNKMKS MLISGKISYE KKIPQVIDLV GVGCSKLRLD 100
YAKKFILECH PNVIKGNMSE MKAIYGIKSS AKGIDVGACD IITEQNFDEN 150
IEMIKRLSME TGSVVAATGV VDIISNGTYT YIISNGCEML SMITGTGCML 200
TGIIASYISS GNILEGTALA IVLMGICGEL SQHVKGTGSF RNELIDNIFS 250
ISDDIIIKKI RINSY 265
Length:265
Mass (Da):28,737
Last modified:May 26, 2009 - v1
Checksum:i29FA7E43C251753A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001581 Genomic DNA. Translation: ACO83484.1.
RefSeqiWP_003358296.1. NC_012563.1.
YP_002804616.1. NC_012563.1.

Genome annotation databases

EnsemblBacteriaiACO83484; ACO83484; CLM_2460.
GeneIDi7767644.
KEGGicby:CLM_2460.
PATRICi19381401. VBICloBot91161_2326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001581 Genomic DNA. Translation: ACO83484.1 .
RefSeqi WP_003358296.1. NC_012563.1.
YP_002804616.1. NC_012563.1.

3D structure databases

ProteinModelPortali C1FR28.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 536232.CLM_2460.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO83484 ; ACO83484 ; CLM_2460 .
GeneIDi 7767644.
KEGGi cby:CLM_2460.
PATRICi 19381401. VBICloBot91161_2326.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi AKPIMAE.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci CBOT536232:GCO3-2383-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Clostridium botulinum A2 Kyoto."
    Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C., Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Kyoto / Type A2.

Entry informationi

Entry nameiTHIM2_CLOBJ
AccessioniPrimary (citable) accession number: C1FR28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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