C1FQW9 (SURE_CLOBJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	CLM_0283

Organism

Clostridium botulinum (strain Kyoto / Type A2) [Complete proteome] [HAMAP]

Taxonomic identifier

536232 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	5'-nucleotidase surE HAMAP MF_00060		PRO_1000196588
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	39	1	Divalent metal cation By similarity
	Metal binding	95	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	C1FQW9 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 51D8DE0140ACA698	FASTA	252	28,210
	10 20 30 40 50 60 MNILLTNDDG IEAEGINTLA ELLSKYHDVT MVAPENQRSA SSHSITIYEP IIVKQVKKPY 70 80 90 100 110 120 NIEAYSISGT PADCVRVALD KLVPDNIDMV ISGINKGLNI GNDILYSGTV SAAIEGAMYK 130 140 150 160 170 180 VPSMAVSAQF IKNKKENYKI AAKYALGMLN RLKKEDLKND VVLNLNIPFC SEEEIKGIKV 190 200 210 220 230 240 CKVGNKIFNT RFSEEIDEEG NKVLKLEGDI NKDIYEGTDV YYIRNKYVTL TPLHYDLTNF 250 NILEETEQLF LS

References

[1]

"Genome sequence of Clostridium botulinum A2 Kyoto." Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C., Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Kyoto / Type A2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001581 Genomic DNA. Translation: ACO83619.1.
RefSeq	YP_002802545.1. NC_012563.1.
3D structure databases
ProteinModelPortal	C1FQW9.
ModBase	Search...
Protein-protein interaction databases
STRING	C1FQW9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7765307.
GenomeReviews	Gene locus CLM_0283 in contig CP001581_GR.
KEGG	cby:CLM_0283.
PATRIC	19377185. VBICloBot91161_0225.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NGFYYVN.
ProtClustDB	PRK13933.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_CLOBJ

Accession

Primary (citable) accession number: C1FQW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program