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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

pdxA

Organism
Clostridium botulinum (strain Kyoto / Type A2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

D-threonate 4-phosphate + NAD+ = dihydroxyacetone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Metal bindingi171Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi215Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi270Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei278SubstrateBy similarity1
Binding sitei296SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.-By similarity)
Gene namesi
Name:pdxA
Ordered Locus Names:CLM_2409
OrganismiClostridium botulinum (strain Kyoto / Type A2)
Taxonomic identifieri536232 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000001374 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001464861 – 334Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST334

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliC1FQK1.
SMRiC1FQK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000221593.
KOiK00097.
OMAiAPVHKGV.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

C1FQK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINNKPIIGI PIGDPAGVGP EIVVKSLTEA EVYEKCNPIL IGDAKVIKQA
60 70 80 90 100
MGFCNVNLNI NSIKKADEGK FTLGTIDLID LNNIDIDELK IGKVQGIAGK
110 120 130 140 150
AAFEYIKKSV EMAKEGELDA IATTPINKES LREGNVNYIG HTEILADLTD
160 170 180 190 200
TEDPLTMFEV RGMRVFFLTR HVSLRKACDL VTKERVLDYI IRCSEALEKL
210 220 230 240 250
GVKDGKMAVA GLNPHSGEHG LFGDEEMKAV VPAIEEAQKM GYKVEGPIGA
260 270 280 290 300
DSVFHLALKG RYNSVLSLYH DQGHIATKTL DFERTIAVTN GMPILRTSVD
310 320 330
HGTAFDIAGT GQASSVSMVE AIILAAKYSP KFKK
Length:334
Mass (Da):36,273
Last modified:May 26, 2009 - v1
Checksum:iD48D3A5B50A457F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001581 Genomic DNA. Translation: ACO86741.1.
RefSeqiWP_012047748.1. NC_012563.1.

Genome annotation databases

EnsemblBacteriaiACO86741; ACO86741; CLM_2409.
KEGGicby:CLM_2409.

Similar proteinsi

Entry informationi

Entry nameiPDXA2_CLOBJ
AccessioniPrimary (citable) accession number: C1FQK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: August 30, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families