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C1FND0

- FTHS_CLOBJ

UniProt

C1FND0 - FTHS_CLOBJ

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, CLM_4009
Organism
Clostridium botulinum (strain Kyoto / Type A2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT536232:GCO3-3895-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:CLM_4009
OrganismiClostridium botulinum (strain Kyoto / Type A2)
Taxonomic identifieri536232 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001374: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000185251Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi536232.CLM_4009.

Structurei

3D structure databases

ProteinModelPortaliC1FND0.
SMRiC1FND0. Positions 5-555.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1FND0-1 [UniParc]FASTAAdd to Basket

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MFKSDIEIAQ ESKMKNIKNI AEKIGLTEED IDLYGKYKCK ISLDVLKSNK    50
DKKDGKLILV TAINPTPAGE GKSTVTVGLG QALWKKNKKA VIALREPSLG 100
PVFGIKGGAA GGGYSQVVPM EDINLHFTGD MHAITSANNL LAAAIDNHIH 150
QGNILKIDQR RILFKRVMDI NDRALRNVIV ALGGKINGFP REDGFMITVA 200
SEIMAILCLA EDLMNLKNKM GEILVAYSTE GKPIYCKDLE VQGAMALLMK 250
DAIKPNLVQT LENTPAIIHG GPFANIAHGC NSILGTKMAL KLGDYVITEA 300
GFGADLGAEK FFDIKCRKAN LKPNCVVIVA TVRALKYNGG IPKENLKEQN 350
MEALSKGIKN LGKHIENVNK FGVPAVVAIN KFISDTEEEI EFIKKYCKEL 400
GAEVSIAEVW EKGGNGGLEL ADKVLDTIEN KESKFNPIYE ETLNIKQKIE 450
TIAQEIYGAE GVDYSKEAEK QISEIEKLDL DKKPVCMAKT QYSLSDDARL 500
LGRPCGFRIN VKEVRISNGA GFIVVLTGNV MTMPGLPKKP AANNMNVLSD 550
GNIVGLF 557
Length:557
Mass (Da):60,708
Last modified:May 26, 2009 - v1
Checksum:i7ACDF728FF10F3D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001581 Genomic DNA. Translation: ACO84041.1.
RefSeqiYP_002806071.1. NC_012563.1.

Genome annotation databases

EnsemblBacteriaiACO84041; ACO84041; CLM_4009.
GeneIDi7766558.
KEGGicby:CLM_4009.
PATRICi19384397. VBICloBot91161_3780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001581 Genomic DNA. Translation: ACO84041.1 .
RefSeqi YP_002806071.1. NC_012563.1.

3D structure databases

ProteinModelPortali C1FND0.
SMRi C1FND0. Positions 5-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 536232.CLM_4009.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO84041 ; ACO84041 ; CLM_4009 .
GeneIDi 7766558.
KEGGi cby:CLM_4009.
PATRICi 19384397. VBICloBot91161_3780.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CBOT536232:GCO3-3895-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Clostridium botulinum A2 Kyoto."
    Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C., Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Kyoto / Type A2.

Entry informationi

Entry nameiFTHS_CLOBJ
AccessioniPrimary (citable) accession number: C1FND0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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