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C1FLB3

- PYRF_CLOBJ

UniProt

C1FLB3 - PYRF_CLOBJ

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, CLM_3650
Organism
Clostridium botulinum (strain Kyoto / Type A2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCBOT536232:GCO3-3546-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:CLM_3650
OrganismiClostridium botulinum (strain Kyoto / Type A2)
Taxonomic identifieri536232 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000001374: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000164745Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi536232.CLM_3650.

Structurei

3D structure databases

ProteinModelPortaliC1FLB3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCDILLTA.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

C1FLB3-1 [UniParc]FASTAAdd to Basket

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MIIDKLYENV EKKGCVCVGL DTDISYLPKG FLNKFTNIED AIFAFNQRIV    50
DSTFDVSACY KVQIAYYEAM GIKGMILYKK TLEYIRKKGG IVIADIKRGD 100
ISATAKMYAK AHFEGDFESD FITLNPYMGM DTLEPYKDYF KNKEKGVFLL 150
LRTSNEGSKD IQYLDLKDNK KVYNKVGEKI ENIGKEFLGN CRYSSIGAVV 200
GCTAEENNIR KELKHTFFLI PGYGAQGGKA EVAKYYLSGG NGGIVNSSRG 250
ILLAYKKYDE EGKNFEECAR NEVINMKKTL QII 283
Length:283
Mass (Da):31,961
Last modified:May 26, 2009 - v1
Checksum:iD111BDF8145B8706
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001581 Genomic DNA. Translation: ACO83525.1.
RefSeqiWP_012703736.1. NC_012563.1.
YP_002805757.1. NC_012563.1.

Genome annotation databases

EnsemblBacteriaiACO83525; ACO83525; CLM_3650.
GeneIDi7767178.
KEGGicby:CLM_3650.
PATRICi19383707. VBICloBot91161_3471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001581 Genomic DNA. Translation: ACO83525.1 .
RefSeqi WP_012703736.1. NC_012563.1.
YP_002805757.1. NC_012563.1.

3D structure databases

ProteinModelPortali C1FLB3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 536232.CLM_3650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO83525 ; ACO83525 ; CLM_3650 .
GeneIDi 7767178.
KEGGi cby:CLM_3650.
PATRICi 19383707. VBICloBot91161_3471.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi CDILLTA.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CBOT536232:GCO3-3546-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Clostridium botulinum A2 Kyoto."
    Shrivastava S., Brinkac L.M., Brown J.L., Bruce D., Detter C.C., Johnson E.A., Munk C.A., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Kyoto / Type A2.

Entry informationi

Entry nameiPYRF_CLOBJ
AccessioniPrimary (citable) accession number: C1FLB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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