C1F9G6 (C1F9G6_ACIC5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA HAMAP MF_00377

Gene names

Name:	dnaA HAMAP MF_00377 EMBL ACO34307.1
Ordered Locus Names:	ACP_2123

Organism

Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]

Taxonomic identifier

240015 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377 RuleBase RU000577
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family. HAMAP MF_00377 RuleBase RU004227

Ontologies

Keywords
Biological process	DNA replication HAMAP MF_00377 RuleBase RU000577
Cellular component	Cytoplasm HAMAP MF_00377
Ligand	ATP-binding HAMAP MF_00377 RuleBase RU000577 DNA-binding HAMAP MF_00377 RuleBase RU000577 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	183 – 190	8	ATP By similarity HAMAP MF_00377

Sequences

	Sequence		Length	Mass (Da)
	C1F9G6 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 94EEF2F212531C89	FASTA	478	54,146
	10 20 30 40 50 60 MSSFATAPAA PLNPWVRILG ALEKKVNRQS YDTWLKPTRF SHVKDRTLIV RIPTTDFRYI 70 80 90 100 110 120 ADRYDDLIHE AIENLQLEFD EVSFVTPEED PMLARAREDG GFAPAPAHAP NTPGNAGAQR 130 140 150 160 170 180 PAQRLNGAMP QQSRFDWSTA AQLNPRYTFD AFVIGSGNQF ARAAAEAVAE RPSKAYNPLF 190 200 210 220 230 240 LYGGVGMGKT HLMHAIGHEV KLRNPSASIC YVSVEKFTNE MISSLRYDKM TTFRDKFRSV 250 260 270 280 290 300 DLLLIDDIQF LSQKERTQEE FFHTFNALHE NMKQIVIASD RPPKELPEIE DRLRSRFEWG 310 320 330 340 350 360 LIADIQPPDL ETKVAILQKK AESEHVLLPT DVALFIASNV RTNVRELEGA LTRLFAWSQL 370 380 390 400 410 420 NGVEISLATT QQCLKQFIDT QVRKITIEAI QRAVAEQFGM RVVELKQKNN SRAVVVPRQI 430 440 450 460 470 AMYLAKQMTE ASLPEIGRQF GGKHHTTVMH SIGKIDEQRR TDKNLNSTLN KLQETLNS

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001472 Genomic DNA. Translation: ACO34307.1.
RefSeq	YP_002755176.1. NC_012483.1.
3D structure databases
ProteinModelPortal	C1F9G6.
ModBase	Search...
Protein-protein interaction databases
STRING	C1F9G6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7698835.
GenomeReviews	Gene locus ACP_2123 in contig CP001472_GR.
KEGG	aca:ACP_2123.
PATRIC	20667511. VBIAciCap40988_2036.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CHTLNAL.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C1F9G6_ACIC5

Accession

Primary (citable) accession number: C1F9G6

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)