C1F976 (C1F976_ACIC5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Homoserine kinase EMBL ACO33352.1
EC=2.7.1.39 EMBL ACO33352.1

Gene names

Name:	thrB EMBL ACO33352.1
Ordered Locus Names:	ACP_0229

Organism

Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]

Taxonomic identifier

240015 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. SAAS SAAS000870
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. SAAS SAAS000870
Sequence similarities	Belongs to the GHMP kinase family. RuleBase RU004209

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis SAAS SAAS000870
Ligand	ATP-binding RuleBase RU003563 SAAS SAAS000870 Nucleotide-binding
Molecular function	Kinase RuleBase RU003563 SAAS SAAS000870 EMBL ACO33352.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C1F976 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: C02DA902F14036A0	FASTA	309	32,643
	10 20 30 40 50 60 MSATASAGPL RLRVPATSAN LGPGFDTLAL ALAMYLEIEA ETAERDGIEA TGRNADLCGE 70 80 90 100 110 120 VDGNLILATY RTLMEREGRT PLPLQMRMKN GIPLGMGCGS SAAARVAGVA LAAHFGTMGW 130 140 150 160 170 180 SRTRIFEEAA RLEGHPDNAA SCVLGGFTVS GETAEKFVAS RIAPSEEWCA VMAIPPEPLA 190 200 210 220 230 240 TSASRGVLPL EYTRADAVRN LQCVALLTAG FAQGDEALVR AGMRDWLHQP YRARVCPLLP 250 260 270 280 290 300 LLLPLAEHPL VMGVALSGAG PSVLLMCQKK FADEVCGMVR QRAGESTEIA ITGLDSDGCE ASSYEIPLW

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001472 Genomic DNA. Translation: ACO33352.1.
RefSeq	YP_002753373.1. NC_012483.1.
3D structure databases
ProteinModelPortal	C1F976.
ModBase	Search...
Protein-protein interaction databases
STRING	C1F976.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7698447.
GenomeReviews	Gene locus ACP_0229 in contig CP001472_GR.
KEGG	aca:ACP_0229.
PATRIC	20663853. VBIAciCap40988_0227.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DRLHQPY.
Family and domain databases
InterPro	IPR006204. GHMP_kinase. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C1F976_ACIC5

Accession

Primary (citable) accession number: C1F976

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)