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C1F935

- GCSPA_ACIC5

UniProt

C1F935 - GCSPA_ACIC5

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, ACP_2098
Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciACAP240015:GKF4-2053-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:ACP_2098
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
ProteomesiUP000002207: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000147973Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi240015.ACP_2098.

Structurei

3D structure databases

ProteinModelPortaliC1F935.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C1F935-1 [UniParc]FASTAAdd to Basket

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MRYLPKSPAD REAMLREIGA ASIDELFAII PEEFRLTRDL AIPRQMGESE    50
IVDHFQAAAA RNANGYASFL GAGAYRHYRP VLIDTIVQRG EFLTSYTPYQ 100
AEITQGTLQA IFEFQTMICE LTGMDIANAS MYDGSTGAAE AVMMAIRVTG 150
RDKVLVSRSV HPEYREVMHT YAQHQGHDAA EVEYIREGAQ AGRVDLAALE 200
AAVTEETACV LVQSPNFFGV IEDIPAIAEI AHKKGALLIV SIAEALSLGA 250
VRPPVEADIV SLEAQSFGVA LSYGGPYCGV LAAKEKYLRQ MPGRLVGETK 300
DSQGRRGFVL TLSTREQHIR REKATSNICT NQALVALMAT VYMTIYGKQG 350
IKDLALQNLA KADYAAKTLG QSGKLLFAGS PRFHEFVLET SETPAQVNER 400
LLEEKIIGGL PLGKWYPELG HAALWCATEV TTREQIDRAA QVLAHAPALA 450
AR 452
Length:452
Mass (Da):49,316
Last modified:May 26, 2009 - v1
Checksum:i36F674F77961312E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO34529.1.
RefSeqiYP_002755153.1. NC_012483.1.

Genome annotation databases

EnsemblBacteriaiACO34529; ACO34529; ACP_2098.
GeneIDi7699611.
KEGGiaca:ACP_2098.
PATRICi20667467. VBIAciCap40988_2016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO34529.1 .
RefSeqi YP_002755153.1. NC_012483.1.

3D structure databases

ProteinModelPortali C1F935.
ModBasei Search...

Protein-protein interaction databases

STRINGi 240015.ACP_2098.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO34529 ; ACO34529 ; ACP_2098 .
GeneIDi 7699611.
KEGGi aca:ACP_2098.
PATRICi 20667467. VBIAciCap40988_2016.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci ACAP240015:GKF4-2053-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51196 / DSM 11244 / JCM 7670.

Entry informationi

Entry nameiGCSPA_ACIC5
AccessioniPrimary (citable) accession number: C1F935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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