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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciACAP240015:G1GV4-2005-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:ACP_2098
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
Proteomesi
  • UP000002207 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001479731 – 452Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST452

Proteomic databases

PRIDEiC1F935

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi240015.ACP_2098

Structurei

3D structure databases

ProteinModelPortaliC1F935
SMRiC1F935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEM Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

C1F935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPKSPAD REAMLREIGA ASIDELFAII PEEFRLTRDL AIPRQMGESE
60 70 80 90 100
IVDHFQAAAA RNANGYASFL GAGAYRHYRP VLIDTIVQRG EFLTSYTPYQ
110 120 130 140 150
AEITQGTLQA IFEFQTMICE LTGMDIANAS MYDGSTGAAE AVMMAIRVTG
160 170 180 190 200
RDKVLVSRSV HPEYREVMHT YAQHQGHDAA EVEYIREGAQ AGRVDLAALE
210 220 230 240 250
AAVTEETACV LVQSPNFFGV IEDIPAIAEI AHKKGALLIV SIAEALSLGA
260 270 280 290 300
VRPPVEADIV SLEAQSFGVA LSYGGPYCGV LAAKEKYLRQ MPGRLVGETK
310 320 330 340 350
DSQGRRGFVL TLSTREQHIR REKATSNICT NQALVALMAT VYMTIYGKQG
360 370 380 390 400
IKDLALQNLA KADYAAKTLG QSGKLLFAGS PRFHEFVLET SETPAQVNER
410 420 430 440 450
LLEEKIIGGL PLGKWYPELG HAALWCATEV TTREQIDRAA QVLAHAPALA

AR
Length:452
Mass (Da):49,316
Last modified:May 26, 2009 - v1
Checksum:i36F674F77961312E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001472 Genomic DNA Translation: ACO34529.1
RefSeqiWP_015897199.1, NC_012483.1

Genome annotation databases

EnsemblBacteriaiACO34529; ACO34529; ACP_2098
KEGGiaca:ACP_2098

Similar proteinsi

Entry informationi

Entry nameiGCSPA_ACIC5
AccessioniPrimary (citable) accession number: C1F935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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