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C1F935 (GCSPA_ACIC5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:ACP_2098
OrganismAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]
Taxonomic identifier240015 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000147973

Sequences

Sequence LengthMass (Da)Tools
C1F935 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 36F674F77961312E

FASTA45249,316
        10         20         30         40         50         60 
MRYLPKSPAD REAMLREIGA ASIDELFAII PEEFRLTRDL AIPRQMGESE IVDHFQAAAA 

        70         80         90        100        110        120 
RNANGYASFL GAGAYRHYRP VLIDTIVQRG EFLTSYTPYQ AEITQGTLQA IFEFQTMICE 

       130        140        150        160        170        180 
LTGMDIANAS MYDGSTGAAE AVMMAIRVTG RDKVLVSRSV HPEYREVMHT YAQHQGHDAA 

       190        200        210        220        230        240 
EVEYIREGAQ AGRVDLAALE AAVTEETACV LVQSPNFFGV IEDIPAIAEI AHKKGALLIV 

       250        260        270        280        290        300 
SIAEALSLGA VRPPVEADIV SLEAQSFGVA LSYGGPYCGV LAAKEKYLRQ MPGRLVGETK 

       310        320        330        340        350        360 
DSQGRRGFVL TLSTREQHIR REKATSNICT NQALVALMAT VYMTIYGKQG IKDLALQNLA 

       370        380        390        400        410        420 
KADYAAKTLG QSGKLLFAGS PRFHEFVLET SETPAQVNER LLEEKIIGGL PLGKWYPELG 

       430        440        450 
HAALWCATEV TTREQIDRAA QVLAHAPALA AR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001472 Genomic DNA. Translation: ACO34529.1.
RefSeqYP_002755153.1. NC_012483.1.

3D structure databases

ProteinModelPortalC1F935.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING240015.ACP_2098.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO34529; ACO34529; ACP_2098.
GeneID7699611.
KEGGaca:ACP_2098.
PATRIC20667467. VBIAciCap40988_2016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycACAP240015:GKF4-2053-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_ACIC5
AccessionPrimary (citable) accession number: C1F935
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families