C1F933 (GCST_ACIC5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	ACP_2096

Organism

Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]

Taxonomic identifier

240015 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Aminomethyltransferase HAMAP MF_00259		PRO_1000125628

Sequences

	Sequence		Length	Mass (Da)
	C1F933 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 1988159355EBF4F2	FASTA	378	41,700
	10 20 30 40 50 60 MSTSAPAALR KTALNAVHRR LGAKMVDFGG WDMPVEYSGL IAEHMAVRTG VGLFDVSHMG 70 80 90 100 110 120 DIQLRGPGSL DAVQHICMND ASKLAVGQAH YSAMLYPQGT FVDDVIVHKF SDNDYLIVIN 130 140 150 160 170 180 AGTREKDYEW IRSHAQPFHC HVSNYSDLYT QLAIQGPRAA ETLAKLTSVD LAAIKNYRFT 190 200 210 220 230 240 WGTVCNLHNT LIARTGYTGE DGFEIYIPSD EATSERVWNE VLEAGKEFGI VPCGLGARNT 250 260 270 280 290 300 LRLESAMALY GHEISQDIDV FEAGLDRYCK LDKGTFVGSE ALKQVVAQGG PKRKLVGLEM 310 320 330 340 350 360 IDRGIARDGY RVLNDTQQAV GYVTSGSPAP FLKKNIALAY VPTELATLDR EVFVEIRNNP 370 VKARIVPTPF YRRPKKQA

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51196 / DSM 11244 / JCM 7670.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001472 Genomic DNA. Translation: ACO32607.1.
RefSeq	YP_002755151.1. NC_012483.1.
3D structure databases
ProteinModelPortal	C1F933.
ModBase	Search...
Protein-protein interaction databases
STRING	C1F933.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7698273.
GenomeReviews	Gene locus ACP_2096 in contig CP001472_GR.
KEGG	aca:ACP_2096.
PATRIC	20667463. VBIAciCap40988_2014.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KALYGGM.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_ACIC5

Accession

Primary (citable) accession number: C1F933

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program