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C1F8U3

- PANC_ACIC5

UniProt

C1F8U3 - PANC_ACIC5

Protein

Pantothenate synthetase

Gene

panC

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei48 – 481Proton donorUniRule annotation
    Binding sitei72 – 721Beta-alanineUniRule annotation
    Binding sitei72 – 721PantoateUniRule annotation
    Binding sitei164 – 1641PantoateUniRule annotation
    Binding sitei187 – 1871ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi41 – 488ATPUniRule annotation
    Nucleotide bindingi158 – 1614ATPUniRule annotation
    Nucleotide bindingi195 – 1984ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciACAP240015:GKF4-1959-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:ACP_2002
    OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
    Taxonomic identifieri240015 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
    ProteomesiUP000002207: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Pantothenate synthetasePRO_1000123394Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi240015.ACP_2002.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiECPIVRE.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1F8U3-1 [UniParc]FASTAAdd to Basket

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    MRRAETIAEI RAAVRELRYR ENPRLKGETW GTRSIGFVPT MGALHEGHLS    50
    LVRAAKAECD AVVASIFVNP TQFGPNEDFG KYPRTVEADC ALLEREGVDA 100
    VFLPQVEEMY PAGATTWVEV EELSGRLDGA SRPGHFRGVA TVVAKLFHIV 150
    GPDRAYFGQK DAAQVANLRR MVRDLDFDLE VVVCPIVREA DGLAMSSRNR 200
    YLSVEERRQG LVLSRALRAM EAGHAAGERD GRRLLAAGAS VMAEEPAVRV 250
    DYLRVVDPET LVDVEAVSGP ALATVAAYVG ATRLIDNVLL GETPAAFKL 299
    Length:299
    Mass (Da):32,598
    Last modified:May 26, 2009 - v1
    Checksum:i214C099252B090BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001472 Genomic DNA. Translation: ACO33519.1.
    RefSeqiYP_002755061.1. NC_012483.1.

    Genome annotation databases

    EnsemblBacteriaiACO33519; ACO33519; ACP_2002.
    GeneIDi7698922.
    KEGGiaca:ACP_2002.
    PATRICi20667281. VBIAciCap40988_1924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001472 Genomic DNA. Translation: ACO33519.1 .
    RefSeqi YP_002755061.1. NC_012483.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 240015.ACP_2002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO33519 ; ACO33519 ; ACP_2002 .
    GeneIDi 7698922.
    KEGGi aca:ACP_2002.
    PATRICi 20667281. VBIAciCap40988_1924.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi ECPIVRE.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci ACAP240015:GKF4-1959-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51196 / DSM 11244 / JCM 7670.

    Entry informationi

    Entry nameiPANC_ACIC5
    AccessioniPrimary (citable) accession number: C1F8U3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3