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C1F8U3

- PANC_ACIC5

UniProt

C1F8U3 - PANC_ACIC5

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Protein

Pantothenate synthetase

Gene

panC

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei48 – 481Proton donorUniRule annotation
Binding sitei72 – 721Beta-alanineUniRule annotation
Binding sitei72 – 721PantoateUniRule annotation
Binding sitei164 – 1641PantoateUniRule annotation
Binding sitei187 – 1871ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 488ATPUniRule annotation
Nucleotide bindingi158 – 1614ATPUniRule annotation
Nucleotide bindingi195 – 1984ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACAP240015:GKF4-1959-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:ACP_2002
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
ProteomesiUP000002207: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Pantothenate synthetasePRO_1000123394Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi240015.ACP_2002.

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiECPIVRE.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

C1F8U3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRAETIAEI RAAVRELRYR ENPRLKGETW GTRSIGFVPT MGALHEGHLS
60 70 80 90 100
LVRAAKAECD AVVASIFVNP TQFGPNEDFG KYPRTVEADC ALLEREGVDA
110 120 130 140 150
VFLPQVEEMY PAGATTWVEV EELSGRLDGA SRPGHFRGVA TVVAKLFHIV
160 170 180 190 200
GPDRAYFGQK DAAQVANLRR MVRDLDFDLE VVVCPIVREA DGLAMSSRNR
210 220 230 240 250
YLSVEERRQG LVLSRALRAM EAGHAAGERD GRRLLAAGAS VMAEEPAVRV
260 270 280 290
DYLRVVDPET LVDVEAVSGP ALATVAAYVG ATRLIDNVLL GETPAAFKL
Length:299
Mass (Da):32,598
Last modified:May 26, 2009 - v1
Checksum:i214C099252B090BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO33519.1.
RefSeqiWP_015897107.1. NC_012483.1.
YP_002755061.1. NC_012483.1.

Genome annotation databases

EnsemblBacteriaiACO33519; ACO33519; ACP_2002.
GeneIDi7698922.
KEGGiaca:ACP_2002.
PATRICi20667281. VBIAciCap40988_1924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO33519.1 .
RefSeqi WP_015897107.1. NC_012483.1.
YP_002755061.1. NC_012483.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240015.ACP_2002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO33519 ; ACO33519 ; ACP_2002 .
GeneIDi 7698922.
KEGGi aca:ACP_2002.
PATRICi 20667281. VBIAciCap40988_1924.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi ECPIVRE.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci ACAP240015:GKF4-1959-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51196 / DSM 11244 / JCM 7670.

Entry informationi

Entry nameiPANC_ACIC5
AccessioniPrimary (citable) accession number: C1F8U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3