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C1F8M1

- PNP_ACIC5

UniProt

C1F8M1 - PNP_ACIC5

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, ACP_0149
Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881Magnesium By similarity
Metal bindingi494 – 4941Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciACAP240015:GKF4-146-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:ACP_0149
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
ProteomesiUP000002207: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_1000185714Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi240015.ACP_0149.

Structurei

3D structure databases

ProteinModelPortaliC1F8M1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHAdd
BLAST
Domaini624 – 69168S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1F8M1-1 [UniParc]FASTAAdd to Basket

« Hide

MKQDVTVELT GGKKLHFETG RMAKQASGAA LVTQGESVVL ATAVAAPDPK    50
EGIDFFPLTV DYREYAYAGG RIPGGFIKRE GRPSEREILT SRQIDRPIRP 100
LFPEGFRNET QVIALVFSAD KENDPDIVGI NAASAALALS DIPFAGPVGA 150
VRVGYVNGEY VINPSYAERR DSSINITVVG TMDGIVMIES GSAEVPEEVV 200
LGAIDFGHTE IKKIVAAINE LAAKAGKTKR AVTAPEFDEA YFETLKNKIG 250
ARLADALDTK AHPKTESYAL VKQIKDELAA EIPADENAGA AKKKLAHYYE 300
LLREKIFREQ VTKDRVRPDR RGFDEIRQIT IEVGVLPRTH GSALFTRGET 350
QALVTATLGT NDDSQRLETF EGEQKKRFML HYNFPPFSVG EVGRMTGVGR 400
REVGHGALAE RAISAVLPGE DESPYALRVV SDILESNGSS SMASVCGASL 450
ALMDAGIPLK GAVAGVAMGL VKEGDEYAIL TDIAGAEDHY GDMDFKVAGT 500
RKGITALQMD IKISGITGQI MREAMEQARR GRMFLLDKMD EILAAPREEK 550
SKHAPQIRTV QIPTDKIRDL IGPGGKTIRG IIEATQVKID VDDTGRVNIA 600
SSDEEGLKKA LAMINDLTAV PEVGKTYLGK VVRLAEFGAF VEIFPGTDGL 650
LHISEIAEHR VKEVKDELHE GDQVMVKVLG VEGNRIKLSR KAVIREQRQK 700
LGLPEPGAEA PAAAEGQPRA ERAERQPSSN ASTITIEGGE DFDDFDEEGG 750
EGEGEDENFN REDTPNSAPG ERRPGGAGAA GNRGRRRRRG RGRGPGQGGG 800
GNRGPQ 806
Length:806
Mass (Da):86,919
Last modified:May 26, 2009 - v1
Checksum:i75A6AAB15E28D9F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO32008.1.
RefSeqiYP_002753295.1. NC_012483.1.

Genome annotation databases

EnsemblBacteriaiACO32008; ACO32008; ACP_0149.
GeneIDi7700782.
KEGGiaca:ACP_0149.
PATRICi20663695. VBIAciCap40988_0148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO32008.1 .
RefSeqi YP_002753295.1. NC_012483.1.

3D structure databases

ProteinModelPortali C1F8M1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240015.ACP_0149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO32008 ; ACO32008 ; ACP_0149 .
GeneIDi 7700782.
KEGGi aca:ACP_0149.
PATRICi 20663695. VBIAciCap40988_0148.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ACAP240015:GKF4-146-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51196 / DSM 11244 / JCM 7670.

Entry informationi

Entry nameiPNP_ACIC5
AccessioniPrimary (citable) accession number: C1F8M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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