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C1F8M1

- PNP_ACIC5

UniProt

C1F8M1 - PNP_ACIC5

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881MagnesiumUniRule annotation
Metal bindingi494 – 4941MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciACAP240015:GKF4-146-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:ACP_0149
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
ProteomesiUP000002207: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Polyribonucleotide nucleotidyltransferasePRO_1000185714Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi240015.ACP_0149.

Structurei

3D structure databases

ProteinModelPortaliC1F8M1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHUniRule annotationAdd
BLAST
Domaini624 – 69168S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1F8M1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKQDVTVELT GGKKLHFETG RMAKQASGAA LVTQGESVVL ATAVAAPDPK
60 70 80 90 100
EGIDFFPLTV DYREYAYAGG RIPGGFIKRE GRPSEREILT SRQIDRPIRP
110 120 130 140 150
LFPEGFRNET QVIALVFSAD KENDPDIVGI NAASAALALS DIPFAGPVGA
160 170 180 190 200
VRVGYVNGEY VINPSYAERR DSSINITVVG TMDGIVMIES GSAEVPEEVV
210 220 230 240 250
LGAIDFGHTE IKKIVAAINE LAAKAGKTKR AVTAPEFDEA YFETLKNKIG
260 270 280 290 300
ARLADALDTK AHPKTESYAL VKQIKDELAA EIPADENAGA AKKKLAHYYE
310 320 330 340 350
LLREKIFREQ VTKDRVRPDR RGFDEIRQIT IEVGVLPRTH GSALFTRGET
360 370 380 390 400
QALVTATLGT NDDSQRLETF EGEQKKRFML HYNFPPFSVG EVGRMTGVGR
410 420 430 440 450
REVGHGALAE RAISAVLPGE DESPYALRVV SDILESNGSS SMASVCGASL
460 470 480 490 500
ALMDAGIPLK GAVAGVAMGL VKEGDEYAIL TDIAGAEDHY GDMDFKVAGT
510 520 530 540 550
RKGITALQMD IKISGITGQI MREAMEQARR GRMFLLDKMD EILAAPREEK
560 570 580 590 600
SKHAPQIRTV QIPTDKIRDL IGPGGKTIRG IIEATQVKID VDDTGRVNIA
610 620 630 640 650
SSDEEGLKKA LAMINDLTAV PEVGKTYLGK VVRLAEFGAF VEIFPGTDGL
660 670 680 690 700
LHISEIAEHR VKEVKDELHE GDQVMVKVLG VEGNRIKLSR KAVIREQRQK
710 720 730 740 750
LGLPEPGAEA PAAAEGQPRA ERAERQPSSN ASTITIEGGE DFDDFDEEGG
760 770 780 790 800
EGEGEDENFN REDTPNSAPG ERRPGGAGAA GNRGRRRRRG RGRGPGQGGG

GNRGPQ
Length:806
Mass (Da):86,919
Last modified:May 26, 2009 - v1
Checksum:i75A6AAB15E28D9F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001472 Genomic DNA. Translation: ACO32008.1.
RefSeqiYP_002753295.1. NC_012483.1.

Genome annotation databases

EnsemblBacteriaiACO32008; ACO32008; ACP_0149.
GeneIDi7700782.
KEGGiaca:ACP_0149.
PATRICi20663695. VBIAciCap40988_0148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001472 Genomic DNA. Translation: ACO32008.1 .
RefSeqi YP_002753295.1. NC_012483.1.

3D structure databases

ProteinModelPortali C1F8M1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240015.ACP_0149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO32008 ; ACO32008 ; ACP_0149 .
GeneIDi 7700782.
KEGGi aca:ACP_0149.
PATRICi 20663695. VBIAciCap40988_0148.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ACAP240015:GKF4-146-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51196 / DSM 11244 / JCM 7670.

Entry informationi

Entry nameiPNP_ACIC5
AccessioniPrimary (citable) accession number: C1F8M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3