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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi488MagnesiumUniRule annotation1
Metal bindingi494MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciACAP240015:G1GV4-148-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:ACP_0149
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
Proteomesi
  • UP000002207 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001857141 – 806Polyribonucleotide nucleotidyltransferaseAdd BLAST806

Proteomic databases

PRIDEiC1F8M1

Interactioni

Protein-protein interaction databases

STRINGi240015.ACP_0149

Structurei

3D structure databases

ProteinModelPortaliC1F8M1
SMRiC1F8M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini555 – 614KHUniRule annotationAdd BLAST60
Domaini624 – 691S1 motifUniRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

C1F8M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQDVTVELT GGKKLHFETG RMAKQASGAA LVTQGESVVL ATAVAAPDPK
60 70 80 90 100
EGIDFFPLTV DYREYAYAGG RIPGGFIKRE GRPSEREILT SRQIDRPIRP
110 120 130 140 150
LFPEGFRNET QVIALVFSAD KENDPDIVGI NAASAALALS DIPFAGPVGA
160 170 180 190 200
VRVGYVNGEY VINPSYAERR DSSINITVVG TMDGIVMIES GSAEVPEEVV
210 220 230 240 250
LGAIDFGHTE IKKIVAAINE LAAKAGKTKR AVTAPEFDEA YFETLKNKIG
260 270 280 290 300
ARLADALDTK AHPKTESYAL VKQIKDELAA EIPADENAGA AKKKLAHYYE
310 320 330 340 350
LLREKIFREQ VTKDRVRPDR RGFDEIRQIT IEVGVLPRTH GSALFTRGET
360 370 380 390 400
QALVTATLGT NDDSQRLETF EGEQKKRFML HYNFPPFSVG EVGRMTGVGR
410 420 430 440 450
REVGHGALAE RAISAVLPGE DESPYALRVV SDILESNGSS SMASVCGASL
460 470 480 490 500
ALMDAGIPLK GAVAGVAMGL VKEGDEYAIL TDIAGAEDHY GDMDFKVAGT
510 520 530 540 550
RKGITALQMD IKISGITGQI MREAMEQARR GRMFLLDKMD EILAAPREEK
560 570 580 590 600
SKHAPQIRTV QIPTDKIRDL IGPGGKTIRG IIEATQVKID VDDTGRVNIA
610 620 630 640 650
SSDEEGLKKA LAMINDLTAV PEVGKTYLGK VVRLAEFGAF VEIFPGTDGL
660 670 680 690 700
LHISEIAEHR VKEVKDELHE GDQVMVKVLG VEGNRIKLSR KAVIREQRQK
710 720 730 740 750
LGLPEPGAEA PAAAEGQPRA ERAERQPSSN ASTITIEGGE DFDDFDEEGG
760 770 780 790 800
EGEGEDENFN REDTPNSAPG ERRPGGAGAA GNRGRRRRRG RGRGPGQGGG

GNRGPQ
Length:806
Mass (Da):86,919
Last modified:May 26, 2009 - v1
Checksum:i75A6AAB15E28D9F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001472 Genomic DNA Translation: ACO32008.1
RefSeqiWP_012680553.1, NC_012483.1

Genome annotation databases

EnsemblBacteriaiACO32008; ACO32008; ACP_0149
KEGGiaca:ACP_0149

Similar proteinsi

Entry informationi

Entry nameiPNP_ACIC5
AccessioniPrimary (citable) accession number: C1F8M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 26, 2009
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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