Non-canonical purine NTP pyrophosphatase - Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Non-canonical purine NTP pyrophosphatase
EC=3.6.1.19

Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name=NTPase

Gene names

Ordered Locus Names:

ACP_0104

Organism

Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]

Taxonomic identifier

240015 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	A nucleoside triphosphate + H₂O = a nucleotide + diphosphate. HAMAP MF_01405
Cofactor	Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphate diphosphatase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 203

203

Non-canonical purine NTP pyrophosphatase HAMAP MF_01405

PRO_1000215200

Regions

Region

9 – 14

6

Substrate binding By similarity

Region

72 – 73

2

Substrate binding By similarity

Sites

Metal binding

42

1

Magnesium or manganese By similarity

Metal binding

72

1

Magnesium or manganese By similarity

Binding site

164

1

Substrate By similarity

Binding site

184

1

Substrate By similarity

Binding site

190

1

Substrate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

C1F8I0 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 2B5DCBB71666A11D
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FASTA

203

21,715

        10         20         30         40         50         60 
MALTLYVASS NAGKLRDFRV AAGHTATEIL PLPGLAEIDA PEETGTTFAE NARLKAEFYS 

        70         80         90        100        110        120 
RCRPGGLVLA DDSGLEVRAL GLLPGVRSAR FAEDAEYLPG SPLSADERNN LLLMDRMRGV 

       130        140        150        160        170        180 
EDRAGRYVCV LSVARDGVEI ASAEGEVAGE ILGVPQGTGG FGYDPLFYLP ELEKTMAEID 

       190        200 
LETKLRLSHR GAALRVLLAR LPG

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References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils."
Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M.

Kuske C.R.
Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51196 / DSM 11244 / JCM 7670.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001472 Genomic DNA. Translation: ACO33253.1.
RefSeq	YP_002753254.1. NC_012483.1.
3D structure databases
ProteinModelPortal	C1F8I0.
ModBase	Search...
Protein-protein interaction databases
STRING	C1F8I0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7698165.
GenomeReviews	Gene locus ACP_0104 in contig CP001472_GR.
KEGG	aca:ACP_0104.
PATRIC	20663607. VBIAciCap40988_0104.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GVYTADW.
ProtClustDB	CLSK2467675.
Family and domain databases
HAMAP	MF_01405. Non_canon_purine_NTPase. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
KO	K02428.
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_ACIC5

Accession

Primary (citable) accession number: C1F8I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents