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C1F8G5

- C1F8G5_ACIC5

UniProt

C1F8G5 - C1F8G5_ACIC5

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd1

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciACAP240015:GKF4-89-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icd1Imported
Ordered Locus Names:ACP_0089Imported
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)Imported
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
ProteomesiUP000002207: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi240015.ACP_0089.

Structurei

3D structure databases

ProteinModelPortaliC1F8G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 2 hits.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1F8G5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQASYNGVSL PEGGQPITYS GGKYTVPDHP IIPFIEGDGT GRDIWRASQR
60 70 80 90 100
VFDAAVHKAY GGQRSVKWFE IFAGEKAFRE FKTWLPDDSV KAATDLRVSI
110 120 130 140 150
KGPLTTPVGG GIRSLNVALR QIMDLYACVR PVKYYAGVPS PVKHPEKLDV
160 170 180 190 200
VIFRENTEDV YAGIEFKQGT PEAKKLIDFL NDEMLKGGKK KVRSDSGVGI
210 220 230 240 250
KPISITGTKR LVRYAIQYAI ENGRRSVTLV HKGNIQKFTE GAFREWGYEV
260 270 280 290 300
AVEEFREHVV TERESWILGN AEANPGLTVE QNAAMIEPGL EFGSEDFRKD
310 320 330 340 350
LYAEIKGVLD SIGQSHGAGK WKQKILINDR IADSIFQQVI IRPDEYDILA
360 370 380 390 400
CPNLNGDYIS DACAAQVGGL GIAPGANIGD GYAVFEATHG TAPKYADKDV
410 420 430 440 450
INPGSVMLSG VMMFEFLGWK EAARLIESAM EKTIQQKHVT YDFERQMPGA
460
TKVKTSEFAT KMIENM
Length:466
Mass (Da):51,501
Last modified:May 26, 2009 - v1
Checksum:i4E35E746973523BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO34056.1.
RefSeqiYP_002753239.1. NC_012483.1.

Genome annotation databases

EnsemblBacteriaiACO34056; ACO34056; ACP_0089.
GeneIDi7697831.
KEGGiaca:ACP_0089.
PATRICi20663579. VBIAciCap40988_0090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001472 Genomic DNA. Translation: ACO34056.1 .
RefSeqi YP_002753239.1. NC_012483.1.

3D structure databases

ProteinModelPortali C1F8G5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240015.ACP_0089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACO34056 ; ACO34056 ; ACP_0089 .
GeneIDi 7697831.
KEGGi aca:ACP_0089.
PATRICi 20663579. VBIAciCap40988_0090.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci ACAP240015:GKF4-89-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 2 hits.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51196 / DSM 11244 / JCM 7670Imported.

Entry informationi

Entry nameiC1F8G5_ACIC5
AccessioniPrimary (citable) accession number: C1F8G5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3