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C1F758 (C1F758_ACIC5) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183 EMBL ACO33529.1
Ordered Locus Names:ACP_1612
OrganismAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]
Taxonomic identifier240015 [NCBI]
Taxonomic lineageBacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding9 – 3830NADP By similarity HAMAP MF_00183

Sites

Metal binding1531Divalent metal cation By similarity HAMAP MF_00183
Metal binding1551Divalent metal cation By similarity HAMAP MF_00183
Metal binding2241Divalent metal cation By similarity HAMAP MF_00183
Binding site1281Substrate By similarity HAMAP MF_00183
Binding site1551Substrate By similarity HAMAP MF_00183
Binding site1791Substrate By similarity HAMAP MF_00183
Binding site2021Substrate By similarity HAMAP MF_00183
Binding site2241Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
C1F758 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 6F5E9194D8AF3369

FASTA39842,653
        10         20         30         40         50         60 
MSLKRIAILG STGSIGQSTL SIIESFPERF AVASLAAGRN LEAAFEQACR WRPLAISLAT 

        70         80         90        100        110        120 
EELAAQLAAR LKAAGVTGIE VLHGTAGTVR VATLPEVDFV VSAIVGVAGL EATYAAVEAG 

       130        140        150        160        170        180 
KPVGLANKEA MVAAGDLLNA AARAKNVPLL PIDSEHNAIH QCMRAGDLHE VKQIWLTASG 

       190        200        210        220        230        240 
GPFRTLPLAD FEHITVAQAL KHPTWVMGRR ITIDSATMLN KGLEIIEACR LFDLPPSAVK 

       250        260        270        280        290        300 
VTVHPQSTVH SLVEYVDGSL LAQISVTDMR LPILYAMTWP ERVASELTFD MTALSQLTFE 

       310        320        330        340        350        360 
TPDFERFPCL RLAYEAAETG GAHTIALNAA DEIAVEAFLE GVIPFPGIPR TIEQVLEATP 

       370        380        390 
HRHPQSITEV LALDEQARET ARKLLAPAFR DAATPSRV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001472 Genomic DNA. Translation: ACO33529.1.
RefSeqYP_002754691.1. NC_012483.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC1F758.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7698920.
GenomeReviewsGene locus ACP_1612 in contig CP001472_GR.
KEGGaca:ACP_1612.
PATRIC20666519. VBIAciCap40988_1546.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIHSMVEY.
ProtClustDBPRK05447.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC1F758_ACIC5
AccessionPrimary (citable) accession number: C1F758
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info