C1F753 (C1F753_ACIC5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Tetraacyldisaccharide 4'-kinase HAMAP MF_00409
EC=2.7.1.130 HAMAP MF_00409

Alternative name(s):
Lipid A 4'-kinase HAMAP MF_00409

Gene names

Name:	lpxK HAMAP MF_00409 EMBL ACO33998.1
Ordered Locus Names:	ACP_1607

Organism

Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]

Taxonomic identifier

240015 [NCBI]

Taxonomic lineage

Bacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) By similarity. HAMAP MF_00409 SAAS SAAS003758
Catalytic activity	ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate). HAMAP MF_00409 SAAS SAAS003758
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6. HAMAP MF_00409 SAAS SAAS003758
Sequence similarities	Belongs to the LpxK family. HAMAP MF_00409

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00409 SAAS SAAS003758 Lipid synthesis
Ligand	ATP-binding HAMAP MF_00409 SAAS SAAS003758 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00409 SAAS SAAS003758 EMBL ACO33998.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP tetraacyldisaccharide 4'-kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C1F753 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 6F2A0D35577CFD22	FASTA	354	38,667
	10 20 30 40 50 60 MNPQRLLAPL TPLYALGLAL KNRRYDGYKN GQKDSATVQR LAWPVISVGN LSVGGAGKTP 70 80 90 100 110 120 VVMRLVELLR EEGMHADVLS RGYGRRSQGV ARVPSADAAG NAEDHLAAQY GDEPVLIAAT 130 140 150 160 170 180 THAPVYVGAS RYEAGQLAER EAAFAHEEPG SARAVHILDD GFQHRQLARD LDIVVLHASD 190 200 210 220 230 240 FHEWLLPAGR LREPLRALRR ADVLVLREED SDLDSDLAAR LDALDLQQPR WLVRRSLQMP 250 260 270 280 290 300 AGLPAQTPVL AFCGIARPRE FFAALTAQGA NLVAQAAFRD HRAFTAADLD YLLALARKHQ 310 320 330 340 350 VQAFVTTEKD AIRLTAAQRA RLSRAAPVLT APLTVQFLEE SAVRAQLLAA VCRQ

References

[1]

"Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils." Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M., Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B., Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C., Davidsen T.M. , DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S., Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P., Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q., Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R., Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R. Appl. Environ. Microbiol. 75:2046-2056(2009) [PubMed: 19201974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001472 Genomic DNA. Translation: ACO33998.1.
RefSeq	YP_002754686.1. NC_012483.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C1F753.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7701131.
GenomeReviews	Gene locus ACP_1607 in contig CP001472_GR.
KEGG	aca:ACP_1607.
PATRIC	20666509. VBIAciCap40988_1541.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VILMDDG.
ProtClustDB	CLSK2467875.
Family and domain databases
HAMAP	MF_00409. LpxK. [Tree]
InterPro	IPR003758. Tetraacyldisaccharide_4-kinase. [Graphical view]
KO	K00912.
Pfam	PF02606. LpxK. 1 hit. [Graphical view]
TIGRFAMs	TIGR00682. LpxK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C1F753_ACIC5

Accession

Primary (citable) accession number: C1F753

Entry history

Integrated into UniProtKB/TrEMBL:	May 26, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)