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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciACAP240015:GKF4-3434-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:ACP_3488
OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Taxonomic identifieri240015 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
ProteomesiUP000002207 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Lipid-A-disaccharide synthasePRO_1000205842Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi240015.ACP_3488.

Structurei

3D structure databases

ProteinModelPortaliC1F718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

C1F718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPNIFLS AGEASGEHYG AALIPALRAL YADARFFGLG GQRMQALGME
60 70 80 90 100
RIVRAEDVAV MGITEVVRHL PRIYGEYLKL KRSIIERKPD LAILIDFPDV
110 120 130 140 150
NLSLARTLHE QGTPVLYFVS PQLWAWKKYR IRKVQRYVDR MLVIFPFEEA
160 170 180 190 200
FYQGHGVQAD FVGHPLTEVP LPTITRAEFA AAHHLDPAKH WVGLLPGSRG
210 220 230 240 250
KEIRLNLPEM IAAAKQLGHE HEYVLPLAPT LTEAQRGHVR QMLAALTASA
260 270 280 290 300
HDAAHDQAPR ITVVADARAT LHHARASIVA SGTATVEAAL IGNPFVVVYR
310 320 330 340 350
VSPLSYAIAR RVVTVPHVAM ANLIADRRVV PELIQDDFTA ANIVREMQPL
360 370 380 390 400
VASDRAREQM MTGLAEVRAK LSTPGSSAIA RVTKVAHEML QRRAALSRVR
Length:400
Mass (Da):44,132
Last modified:May 26, 2009 - v1
Checksum:i4BC3AF596950F498
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001472 Genomic DNA. Translation: ACO32014.1.
RefSeqiWP_015898516.1. NC_012483.1.
YP_002756482.1. NC_012483.1.

Genome annotation databases

EnsemblBacteriaiACO32014; ACO32014; ACP_3488.
KEGGiaca:ACP_3488.
PATRICi20670177. VBIAciCap40988_3344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001472 Genomic DNA. Translation: ACO32014.1.
RefSeqiWP_015898516.1. NC_012483.1.
YP_002756482.1. NC_012483.1.

3D structure databases

ProteinModelPortaliC1F718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi240015.ACP_3488.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO32014; ACO32014; ACP_3488.
KEGGiaca:ACP_3488.
PATRICi20670177. VBIAciCap40988_3344.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciACAP240015:GKF4-3434-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51196 / DSM 11244 / JCM 7670.

Entry informationi

Entry nameiLPXB_ACIC5
AccessioniPrimary (citable) accession number: C1F718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: April 1, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.