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C1F718

- LPXB_ACIC5

UniProt

C1F718 - LPXB_ACIC5

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciACAP240015:GKF4-3434-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:ACP_3488
    OrganismiAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670)
    Taxonomic identifieri240015 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium
    ProteomesiUP000002207: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Lipid-A-disaccharide synthasePRO_1000205842Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi240015.ACP_3488.

    Structurei

    3D structure databases

    ProteinModelPortaliC1F718.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018004.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1F718-1 [UniParc]FASTAAdd to Basket

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    MSSAPNIFLS AGEASGEHYG AALIPALRAL YADARFFGLG GQRMQALGME    50
    RIVRAEDVAV MGITEVVRHL PRIYGEYLKL KRSIIERKPD LAILIDFPDV 100
    NLSLARTLHE QGTPVLYFVS PQLWAWKKYR IRKVQRYVDR MLVIFPFEEA 150
    FYQGHGVQAD FVGHPLTEVP LPTITRAEFA AAHHLDPAKH WVGLLPGSRG 200
    KEIRLNLPEM IAAAKQLGHE HEYVLPLAPT LTEAQRGHVR QMLAALTASA 250
    HDAAHDQAPR ITVVADARAT LHHARASIVA SGTATVEAAL IGNPFVVVYR 300
    VSPLSYAIAR RVVTVPHVAM ANLIADRRVV PELIQDDFTA ANIVREMQPL 350
    VASDRAREQM MTGLAEVRAK LSTPGSSAIA RVTKVAHEML QRRAALSRVR 400
    Length:400
    Mass (Da):44,132
    Last modified:May 26, 2009 - v1
    Checksum:i4BC3AF596950F498
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001472 Genomic DNA. Translation: ACO32014.1.
    RefSeqiWP_015898516.1. NC_012483.1.
    YP_002756482.1. NC_012483.1.

    Genome annotation databases

    EnsemblBacteriaiACO32014; ACO32014; ACP_3488.
    GeneIDi7700417.
    KEGGiaca:ACP_3488.
    PATRICi20670177. VBIAciCap40988_3344.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001472 Genomic DNA. Translation: ACO32014.1 .
    RefSeqi WP_015898516.1. NC_012483.1.
    YP_002756482.1. NC_012483.1.

    3D structure databases

    ProteinModelPortali C1F718.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 240015.ACP_3488.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACO32014 ; ACO32014 ; ACP_3488 .
    GeneIDi 7700417.
    KEGGi aca:ACP_3488.
    PATRICi 20670177. VBIAciCap40988_3344.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018004.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci ACAP240015:GKF4-3434-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51196 / DSM 11244 / JCM 7670.

    Entry informationi

    Entry nameiLPXB_ACIC5
    AccessioniPrimary (citable) accession number: C1F718
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3