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C1F718 (LPXB_ACIC5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:ACP_3488
OrganismAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]
Taxonomic identifier240015 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeAcidobacterium

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_1000205842

Sequences

Sequence LengthMass (Da)Tools
C1F718 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 4BC3AF596950F498

FASTA40044,132
        10         20         30         40         50         60 
MSSAPNIFLS AGEASGEHYG AALIPALRAL YADARFFGLG GQRMQALGME RIVRAEDVAV 

        70         80         90        100        110        120 
MGITEVVRHL PRIYGEYLKL KRSIIERKPD LAILIDFPDV NLSLARTLHE QGTPVLYFVS 

       130        140        150        160        170        180 
PQLWAWKKYR IRKVQRYVDR MLVIFPFEEA FYQGHGVQAD FVGHPLTEVP LPTITRAEFA 

       190        200        210        220        230        240 
AAHHLDPAKH WVGLLPGSRG KEIRLNLPEM IAAAKQLGHE HEYVLPLAPT LTEAQRGHVR 

       250        260        270        280        290        300 
QMLAALTASA HDAAHDQAPR ITVVADARAT LHHARASIVA SGTATVEAAL IGNPFVVVYR 

       310        320        330        340        350        360 
VSPLSYAIAR RVVTVPHVAM ANLIADRRVV PELIQDDFTA ANIVREMQPL VASDRAREQM 

       370        380        390        400 
MTGLAEVRAK LSTPGSSAIA RVTKVAHEML QRRAALSRVR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001472 Genomic DNA. Translation: ACO32014.1.
RefSeqYP_002756482.1. NC_012483.1.

3D structure databases

ProteinModelPortalC1F718.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING240015.ACP_3488.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACO32014; ACO32014; ACP_3488.
GeneID7700417.
KEGGaca:ACP_3488.
PATRIC20670177. VBIAciCap40988_3344.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OMAVSPITYR.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycACAP240015:GKF4-3434-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_ACIC5
AccessionPrimary (citable) accession number: C1F718
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways