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C1F5Y2 (C1F5Y2_ACIC5) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 2 HAMAP MF_00420
EC=6.3.5.3 HAMAP MF_00420
Alternative name(s):
Phosphoribosylformylglycinamidine synthase II HAMAP MF_00420
Gene names
Name:purL HAMAP MF_00420 EMBL ACO34038.1
Ordered Locus Names:ACP_1391
OrganismAcidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / JCM 7670) [Complete proteome] [HAMAP]
Taxonomic identifier240015 [NCBI]
Taxonomic lineageBacteria › Acidobacteria › Acidobacteriales › Acidobacteriaceae › Acidobacterium

Protein attributes

Sequence length785 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00420

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00420

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP MF_00420

Subcellular location

Cytoplasm By similarity HAMAP MF_00420.

Sequence similarities

Belongs to the FGAMS family. HAMAP MF_00420

Ontologies

Keywords
   Biological processPurine biosynthesis HAMAP MF_00420
   Cellular componentCytoplasm HAMAP MF_00420
   LigandATP-binding HAMAP MF_00420
Nucleotide-binding
   Molecular functionLigase HAMAP MF_00420 EMBL ACO34038.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

phosphoribosylformylglycinamidine synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C1F5Y2 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 9BE2455B274DF5B0

FASTA78584,174
        10         20         30         40         50         60 
MAPHPAAITP ELLQQHGITP EEYQRILTAL GRTPSMTELG IYSVMWSEHC SYKSSRVHLK 

        70         80         90        100        110        120 
RLPTESDRVV QGPGENAGII DVGDGWACAF KIESHNHPSY IEPYQGAATG VGGILRDIFT 

       130        140        150        160        170        180 
MGARPLAVMD SLRFGPIHSE EWVPQVRVSG PGLDTESEAV LHKNHSILEG VVHGIAGYGN 

       190        200        210        220        230        240 
CFGVPNLGGE TRFEPCYSGN PLVNAFALGL VKRDEIFYAK ATGVGNPVIY VGAKTGRDGI 

       250        260        270        280        290        300 
HGATMASEEF KEGSEQKRPN VQVGDPFMEK LLLEACIEAM RTGAVVGIQD MGAAGLTSSS 

       310        320        330        340        350        360 
CEMGARGGVG IEMNLDDVPQ RETNMNAYEL MLSESQERML LVAEKGREQE VLDVFTKWGL 

       370        380        390        400        410        420 
DGVVVGEVIA EPRMRIWRNG VLEADIPNQS LTDDAPRYHR PIGTWKAPVP ADPPPAVLAA 

       430        440        450        460        470        480 
LEVRADYTTE LKKLLAASNI CSKRYIYEQY DSMVQTNTAQ GPGAEAGVMR IKESGTPGHE 

       490        500        510        520        530        540 
RGLAMALAGN GRWCYLDPKL GAMHAVAEAA RKVACTGATP VAATNCLNFG NPEKPEIMAQ 

       550        560        570        580        590        600 
LSTAIDGMAE ACTALGTPIT GGNVSLYNET RGEGIYPTPV IGVVGILDDV TKSVPAHFQR 

       610        620        630        640        650        660 
AGDLVYLVGG KSIAGAIGNA LHTFGATEYA RQRFAHLWGD VPALHLDDEA ALHRALAELA 

       670        680        690        700        710        720 
QASAVQSVND VSDGGLAVAL AKNCFPRQIG VRVEVSDPTG TPPEMMLFHE DASLVVASVA 

       730        740        750        760        770        780 
PEKKDDFLRI IAAHAQLFAV QLGETVKQRF TILRNGETLV HTTVSDLFTP WSESLESALQ 


NEVLA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001472 Genomic DNA. Translation: ACO34038.1.
RefSeqYP_002754477.1. NC_012483.1.

3D structure databases

ProteinModelPortalC1F5Y2.
ModBaseSearch...

Protein-protein interaction databases

STRINGC1F5Y2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7699255.
GenomeReviewsGene locus ACP_1391 in contig CP001472_GR.
KEGGaca:ACP_1391.
PATRIC20666093. VBIAciCap40988_1336.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAYGNSFGV.
ProtClustDBPRK01213.

Family and domain databases

HAMAPMF_00420. PurL_2.
[Tree]
InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR010074. PRibForGlyAmidine_synth_II.
IPR016188. PurM_N-like.
[Graphical view]
KOK01952.
PfamPF00586. AIRS. 2 hits.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01736. FGAM_synth_II. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC1F5Y2_ACIC5
AccessionPrimary (citable) accession number: C1F5Y2
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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